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Immune checkpoint inhibitors and vasculitis
Current Opinion in Rheumatology, 2020Purpose of review Clinical use of immune checkpoint inhibitor (ICI) therapy has revolutionized the therapeutic landscape of cancer. By activating the immune system using monoclonal anti-CTLA-4 and PD(L)-1 antibodies, remission can be induced in previously terminal cancers. However, these breakthroughs come at a price.
Patrick, Boland +2 more
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Immune checkpoint receptors in autoimmunity
Current Opinion in Immunology, 2023Immune checkpoint receptors such as programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte associated protein 4 (CTLA-4), lymphocyte-activation gene 3 (LAG-3), and T cell immunoglobulin and ITIM domain (TIGIT) have distinct and overlapping inhibitory functions that regulate Tcell activation, differentiation, and function.
Kelly P, Burke +3 more
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Epigenetics Meets Immune Checkpoints
Seminars in Oncology, 2015Epigenetic alterations play a pivotal role in cancer development and progression. Pharmacologic reversion of such alterations is feasible, and second generation "epigenetic drugs" are in development and have been demonstrated to possess significant immunomodulatory properties.
Covre A. +5 more
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Immune Checkpoint Therapies for Melanoma
Hematology/Oncology Clinics of North America, 2021Immunotherapy with immune checkpoint inhibition has dramatically changed the treatment of melanoma. Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 are approved for the treatment of advanced melanoma alone and in combination.
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2017
Tumor cell transformation prompts to activation of adaptive and innate immune responses, which had a crucial role in eliminating and controlling early cancer growth. Over the past 10 years, there has been a greater understanding of the immune response to tumors which has led to the development of a huge number of immunotherapeutic strategies [1, 2 ...
Esposito, Angela, Curigliano, Giuseppe
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Tumor cell transformation prompts to activation of adaptive and innate immune responses, which had a crucial role in eliminating and controlling early cancer growth. Over the past 10 years, there has been a greater understanding of the immune response to tumors which has led to the development of a huge number of immunotherapeutic strategies [1, 2 ...
Esposito, Angela, Curigliano, Giuseppe
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Immune checkpoint inhibitors in GBM
Journal of Neuro-Oncology, 2021The purpose of this review is to summarize recent updates regarding immune checkpoint inhibitor therapy in GBM patients including updates in brain immunology, clinical trials, mechanisms of resistance, and biomarkers of response.PubMed was searched to identify recent relevant articles on immune checkpoint inhibitor therapy as it pertains to GBM ...
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Immune checkpoint for pregnancy
Seminars in ImmunopathologyA successful pregnancy relies on the precise regulation of the maternal immune system to recognize and tolerate the allogeneic fetus, while simultaneously preventing infection. Immune checkpoint molecules (ICMs), such as programmed death receptor 1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), T cell immunoglobulin, and mucin-domain containing-3 ...
Xiaohui Hu, Siying Lai, Aihua Liao
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2015
Undoubtedly the discovery of immune checkpoints such as CTLA-4 and PD-1 has been crucial to the development of cancer immunotherapy. Although these molecules were originally discovered as molecules playing a role in T cell activation or apoptosis, subsequent preclinical research showed their important role in the maintenance of peripheral immune ...
John B A G, Haanen, Caroline, Robert
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Undoubtedly the discovery of immune checkpoints such as CTLA-4 and PD-1 has been crucial to the development of cancer immunotherapy. Although these molecules were originally discovered as molecules playing a role in T cell activation or apoptosis, subsequent preclinical research showed their important role in the maintenance of peripheral immune ...
John B A G, Haanen, Caroline, Robert
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Microglial immune checkpoint mechanisms
Nature Neuroscience, 2018Microglia differentiate from progenitors that infiltrate the nascent CNS during early embryonic development. They then remain in this unique immune-privileged environment throughout life. Multiple immune mechanisms, which we collectively refer to as microglial checkpoints, ensure efficient and tightly regulated microglial responses to perturbations in ...
Aleksandra Deczkowska +2 more
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CD200 is an atheroprotective immune checkpoint
Nature Reviews Cardiology, 2021The CD200 inhibitory immune checkpoint promotes arterial homeostasis and reduces atherosclerotic plaque progression and inflammation in mice by limiting the excessive supply, recruitment and activation of monocytes and macrophages during atherogenesis, according to a new study.
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