Results 61 to 70 of about 1,989,151 (330)

Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification

Journal for ImmunoTherapy of Cancer, 2019
Background Permanence of front-line management of lung cancer by immunotherapies requires predictive companion diagnostics identifying immune-checkpoints at baseline, challenged by the size and heterogeneity of biopsy specimens.
Anne Monette, Derek Bergeron, Amira Ben Amor, Liliane Meunier, Christine Caron, Anne-Marie Mes-Masson, Nidhameddine Kchir, Kamel Hamzaoui, Igor Jurisica, Réjean Lapointe   +9 more
doaj   +1 more source

A novel immune checkpoints-based signature to predict prognosis and response to immunotherapy in lung adenocarcinoma

Journal of Translational Medicine, 2022
Background Except for B7-CD28 family members, more novel immune checkpoints are being discovered. They are closely associated with tumor immune microenvironment and regulate the function of many immune cells.
Nan Sun, Yuejun Luo, Bo Zheng, Zhihui Zhang, Chaoqi Zhang, Zhen Zhang, Guochao Zhang, Fengwei Tan, Qi Xue, Shugeng Gao, Jie He   +10 more
doaj   +1 more source

The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers

Biomolecules, 2022
The Epstein-Barr Virus (EBV) is a gammaherpesvirus involved in the etiopathogenesis of a variety of human cancers, mostly of lymphoid and epithelial origin. The EBV infection participates in both cell transformation and tumor progression, also playing an
Alison Felipe Bordini Biggi, Deilson Elgui de Oliveira   +1 more
doaj   +1 more source

Immune checkpoints and immunotherapy for colorectal cancer [PDF]

, 2015
cance
Krishnan, Gayathri, Lockhart, A. Craig, Sharma, Piyush K, Singh, Preet Paul   +3 more
core   +3 more sources

Targeting the NF-κB pathway as a potential regulator of immune checkpoints in cancer immunotherapy

Cellular and Molecular Life Sciences
Advances in cancer immunotherapy over the last decade have led to the development of several agents that affect immune checkpoints. Inhibitory receptors expressed on T cells that negatively regulate the immune response include cytotoxic T‑lymphocyte ...
Nasim Ebrahimi, Al-Hasnawi Rasool Riyadh Abdulwahid, Atena Mansouri, N. Karimi, Rashid Jafardoust Bostani, Sheida Beiranvand, Samaneh Adelian, Roya Khorram, Reza Vafadar, Michael R. Hamblin, A. Aref   +10 more
semanticscholar   +1 more source

Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma

Cancer Biology & Medicine, 2020
In the interaction between a tumor and the immune system, immune checkpoints play an important role, and in tumor immune escape, co-inhibitory immune checkpoints are important.
Shaoping Shen, Ling Chen, Jialin Liu, Lin Yang, Mengna Zhang, Lingxiong Wang, Rong Zhang, Yasushi Uemura, Qiyan Wu, Xinguang Yu, Tianyi Liu   +10 more
doaj   +1 more source

MicroRNAs as regulators of immune checkpoints in cancer immunotherapy: targeting PD-1/PD-L1 and CTLA-4 pathways

Cancer Cell International
Immunotherapy has revolutionized cancer treatment by harnessing the power of the immune system to eliminate tumors. Immune checkpoint inhibitors (ICIs) block negative regulatory signals that prevent T cells from attacking cancer cells.
Arefeh Zabeti Touchaei, S. Vahidi
semanticscholar   +1 more source

Immune Checkpoints in Cancers: From Signaling to the Clinic

Cancers, 2021
Simple Summary Immune checkpoint therapies are treatments used to fight cancers by reactivating a patient’s own immune system. Melanoma was the first cancer to benefit from these treatments.
Céline Pisibon, Amira Ouertani, C. Bertolotto, R. Ballotti, Y. Cheli   +4 more
semanticscholar   +1 more source

Inhibitors of Immune Checkpoints: Small Molecule- and Peptide-Based Approaches

Journal of Personalized Medicine
The revolutionary progress in cancer immunotherapy, particularly the advent of immune checkpoint inhibitors, marks a significant milestone in the fight against malignancies.
Natalie Fuchs, Longfei Zhang, Laura Calvo-Barreiro, Katarzyna Kuncewicz, Moustafa T. Gabr   +4 more
semanticscholar   +1 more source

Expression patterns of immune checkpoints in acute myeloid leukemia

Journal of Hematology & Oncology, 2020
Immunotherapy with immune checkpoint inhibitors (ICIs) for solid tumors had significantly improved overall survival. This type of therapy is still not available for acute myeloid leukemia (AML). One major issue is the lack of knowledge for the expression
Cunte Chen, Chaofeng Liang, Shunqing Wang, Chi Leong Chio, Yuping Zhang, Chengwu Zeng, Shaohua Chen, Caixia Wang, Yangqiu Li   +8 more
semanticscholar   +1 more source