Results 41 to 50 of about 1,252,407 (298)

Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification

Journal for ImmunoTherapy of Cancer, 2019
Background Permanence of front-line management of lung cancer by immunotherapies requires predictive companion diagnostics identifying immune-checkpoints at baseline, challenged by the size and heterogeneity of biopsy specimens.
Anne Monette, Derek Bergeron, Amira Ben Amor, Liliane Meunier, Christine Caron, Anne-Marie Mes-Masson, Nidhameddine Kchir, Kamel Hamzaoui, Igor Jurisica, Réjean Lapointe   +9 more
doaj   +1 more source

Single-cell immune checkpoint landscape of PBMCs stimulated with Candida albicans

Emerging Microbes and Infections, 2021
Immune checkpoints play various important roles in tumour immunity, which usually contribute to T cells’ exhaustion, leading to immunosuppression in the tumour microenvironment.
Weiwei Deng, Zhen Su, Panpan Liang, Yubo Ma, Yufang Liu, Kai Zhang, Yi Zhang, Tianyu Liang, Jin Shao, Xiao Liu, Wenling Han, Ruoyu Li   +11 more
doaj   +1 more source

Clinical Insights Into Novel Immune Checkpoint Inhibitors

Frontiers in Pharmacology, 2021
The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1), and programmed death ligand-1 (PD-L1), has revolutionized treatment options ...
Jii Bum Lee, Jii Bum Lee, Sang-Jun Ha, Hye Ryun Kim   +3 more
doaj   +1 more source

Immune Checkpoints and Inhibitors

, 2019
Antigen-specific T cells encountering and responding to tumor cells are regulated by a variety of mechanisms including inhibitory receptors and regulatory T cells to prevent overexposure immune responses.
Özge Baş Aksu, Şule Şengül
core   +1 more source

SnapShot: APC/T Cell Immune Checkpoints

, 2020
: Immune checkpoints are key regulatory mechanisms integral to the maintenance of self-tolerance and execution of antigen-specific immune responses. In recent years, they have been leveraged to treat both autoimmune disease and various forms of cancer ...
Christina Kiel, Shrager, Scott H, Kiel, Christina, Scott H. Shrager   +3 more
core   +1 more source

Table_9_Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.xlsx

, 2022
Chronic lymphocytic leukemia (CLL) is a lymphoid neoplasm characterized by the accumulation of mature B cells. The diagnosis is established by the detection of monoclonal B lymphocytes in peripheral blood, even in early stages [monoclonal B-cell ...
Juanes-Velasco, Pablo, Lécrevisse, Quentin, Fuentes, Manuel, Carlos Eduardo Pedreira (8497368), González, Marcos, Marcos González (120382), Landeira-Viñuela, Alicia, Laura Díaz-Muñoz (13873298), Hernández, Ángela-Patricia, Orfao, Alberto, Díaz-Muñoz, Laura, Arias-Hidalgo, Carlota, Marina L. García-Vaquero (12010898), Quentin Lecrevisse (8041148), Almudena Navarro-Bailón (11808457), Alcoceba, Miguel, Miguel Alcoceba (3805117), Rafael Góngora (10498154), Pedreira, C. E., Pablo Juanes-Velasco (10498160), Alberto Orfao (108164), Manuel Fuentes (143757), Ángela-Patricia Hernández (12010907), José Manuel Sánchez-Santos (13873301), García-Vaquero, Marina L., Alicia Landeira-Viñuela (10498157), Carlota Arias-Hidalgo (13873295), Javier De Las Rivas (19407), De Las Rivas, Javier, Navarro-Bailón, Almudena, Góngora, Rafael, Sánchez-Santos, José Manuel   +31 more
core   +1 more source

Immune checkpoints, their control by immunotherapy and ovarian cancer

, 2017
Immune checkpoints are new targets for manipulation of immunological control over malignant tumors. They provide an important means to manage especially recurrent and refractory cancers and those cancers where there is an unmet need such as recurrent ...
Chinmoy K. Bose
core   +1 more source

Immune Checkpoints in Solid Organ Transplantation

Biology, 2023
Allogenic graft acceptance is only achieved by life-long immunosuppression, which comes at the cost of significant toxicity. Clinicians face the challenge of adapting the patients’ treatments over long periods to lower the risks associated with these ...
Arnaud Del Bello, Emmanuel Treiner
doaj   +1 more source

Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma

Cancer Biology & Medicine, 2020
In the interaction between a tumor and the immune system, immune checkpoints play an important role, and in tumor immune escape, co-inhibitory immune checkpoints are important.
Shaoping Shen, Ling Chen, Jialin Liu, Lin Yang, Mengna Zhang, Lingxiong Wang, Rong Zhang, Yasushi Uemura, Qiyan Wu, Xinguang Yu, Tianyi Liu   +10 more
doaj   +1 more source

A novel immune checkpoints-based signature to predict prognosis and response to immunotherapy in lung adenocarcinoma

Journal of Translational Medicine, 2022
Background Except for B7-CD28 family members, more novel immune checkpoints are being discovered. They are closely associated with tumor immune microenvironment and regulate the function of many immune cells.
Nan Sun, Yuejun Luo, Bo Zheng, Zhihui Zhang, Chaoqi Zhang, Zhen Zhang, Guochao Zhang, Fengwei Tan, Qi Xue, Shugeng Gao, Jie He   +10 more
doaj   +1 more source