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Immune checkpoint inhibitors [PDF]
Journal of Cell Biology, 2019 Hui details the cell biology underlying the action of immune checkpoint inhibitors.
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NK Cell-Based Immune Checkpoint Inhibition
Frontiers in Immunology, 2020 Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an important mode of treatment for cancer patients. The inhibition of immune checkpoints, which are the source of immune escape for various cancers, is one such ...
Muhammad Khan, Sumbal Arooj, Hua Wang
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Frontiers in Cell and Developmental Biology, 2023 Background: Lung adenocarcinoma (LUAD) is the most common variant of non–small cell lung cancer (NSCLC) across the world. Recently, the rapid development of immunotherapy has brought a new dawn for LUAD patients.
Linbin Hua +6 more
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Cancer therapeutic implications of microRNAs in the regulation of immune checkpoint blockade [PDF]
ExRNA, 2019 Dampening of patients’ immune response to tumor-specific antigens is a major reason for tumor development and progression. Within tumor microenvironment, aberrant expression of immune checkpoints changes T lymphocyte activity, and induces immune ...
Yan Zhang +2 more
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Myocarditis with Immune Checkpoint Blockade [PDF]
New England Journal of Medicine, 2017 In their discussion of fulminant myocarditis and complete heart block during immune checkpoint therapy, Johnson et al. do not discuss the possible role of circulating anticonductive tissue autoantibodies (ACTA) in the pathogenesis of the sudden heart block and myocarditis.1 Since it is not known which autoantigens (other than troponin I, which was ...
Javid J, Moslehi +2 more
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Immune Checkpoint Inhibitors and Neurotoxicity
Current Neuropharmacology, 2021 : Immune checkpoint inhibitors (ICIs) have recently been used as a promising treatment for cancer, while their toxicity and immune-related side effects can be seen in any organ, including the nervous system. In contrast to other immune-related adverse events (irAEs), neurological irAEs (nAEs) are rare, with varying incidence and symptom complexity ...
Zhao, Zhiyi +4 more
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Soluble immune checkpoints in cancer: production, function and biological significance
Journal for ImmunoTherapy of Cancer, 2018 Immune checkpoints play important roles in immune regulation, and blocking immune checkpoints on the cell membrane is a promising strategy in the treatment of cancer.
Daqian Gu +4 more
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Immune Checkpoint Inhibitors in Melanoma [PDF]
Melanoma Management, 2015 The potential to harness the power of the immune system and effectively treat patients with metastatic melanoma is finally being realized with the advent of immune checkpoint inhibitors. These new therapies herald a new era in the treatment of melanoma with the potential to produce very durable responses and possible cure for a subset of patients ...
Adam J, Cooper +2 more
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Single-cell immune checkpoint landscape of PBMCs stimulated with Candida albicans
Emerging Microbes and Infections, 2021 Immune checkpoints play various important roles in tumour immunity, which usually contribute to T cells’ exhaustion, leading to immunosuppression in the tumour microenvironment.
Weiwei Deng +11 more
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CANCER IMMUNOTHERAPY BASED ON THE BLOCKADE OF IMMUNE CHECKPOINTS
Медицинская иммунология, 2015 Immune checkpoints represent the system of inhibitory mechanisms regulating the activation of the immune response, preventing the autoimmune processes and modulating the immune response by decreasing the immune cell-mediated damage of tissues and organs.
A. V. Bogolyubova +3 more
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