Results 11 to 20 of about 66,883 (257)
Immune Checkpoints in Viral Infections [PDF]
Viruses, 2020 As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system ...
Huiming Cai +11 more
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Immune checkpoint inhibitors [PDF]
Journal of Experimental Medicine, 2021 Three papers by James Allison and Tasuku Honjo published in JEM between 1995 and 2000 crystallized seminal insights into the role of CTLA-4 and PD-1 in immunosuppression (Krummel and Allison. 1995. J. Exp. Med.https://doi.org/10.1084/jem.182.2.459; van Elsas et al. 1999. J. Exp. Med.https://doi.org/10.1084/jem.190.3.355; Freeman et al. 2000. J.
Kroemer, Guido, Zitvogel, Laurence
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Immune Checkpoint Inhibitors and the Heart [PDF]
Frontiers in Cardiovascular Medicine, 2021 Immune checkpoint inhibitors (ICIs) represent a break-through treatment for a large number of cancer types. This treatment is increasingly being recommended. ICIs are prescribed for primary tumours and for metastases, adjuvant/neo-adjuvant therapy.
Diana Larisa Mocan-Hognogi +11 more
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Emerging phagocytosis checkpoints in cancer immunotherapy
Signal Transduction and Targeted Therapy, 2023 Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as it utilizes patients’ own immune systems in combating the cancer cells.
Yu’e Liu +9 more
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Acta Pharmaceutica Sinica B, 2021 Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance, preventing autoimmune responses, and minimizing tissue damage by regulating the duration and intensity of the immune response ...
Yuli Wang +10 more
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Immune checkpoint receptors: homeostatic regulators of immunity [PDF]
Hepatology International, 2018 Alcoholic liver disease (ALD) is an escalating global problem accounting for more than 3 million deaths annually. Bacterial infections are diagnosed in 25-47% of hospitalized patients with cirrhosis and represent the most important trigger for acute decompensation, multi-organ failure, septic shock and death.
Antonio Riva, Shilpa Chokshi
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Immune checkpoint inhibitors for multiple myeloma immunotherapy
Experimental Hematology & Oncology, 2023 Multiple myeloma (MM) is related to immune disorders, recent studys have revealed that immunotherapy can greatly benefit MM patients. Immune checkpoints can negatively modulate the immune system and are closely associated with immune escape.
Zhaoyun Liu +5 more
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Archetypes of checkpoint-responsive immunity
Trends in Immunology, 2021 Responsiveness to immune checkpoint blockade (ICB) therapy in cancer is currently predicted by disparate individual measures - with varying degrees of accuracy - including tumor mutation burden, tumor-infiltrating T cell densities, dendritic cell frequencies, and the expression of checkpoint ligands.
Kwok, Im +4 more
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Immune checkpoint inhibitors in malignancy [PDF]
Australian Prescriber, 2019 Immune checkpoints normally stop the body from mounting an immune response against healthy cells. Some cancers can acquire these checkpoints so that the tumour cells are not recognised by the immune systemInhibiting the checkpoints therefore enables the tumour cells to be recognised and allows an immune response to be activated against themImmune ...
Luke, Ardolino, Anthony, Joshua
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Cardiotoxicity of Immune Checkpoint Inhibitors [PDF]
Current Oncology Reports, 2021 Immune checkpoint inhibitors (ICIs) have improved the survival of several cancers. However, they may cause a wide range of immune-related adverse events (irAEs). While most irAEs are manageable with temporary cessation of ICI and immunosuppression, cardiovascular toxicity can be associated with high rates of morbidity and mortality.
Rushin P. Patel +6 more
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