Results 31 to 40 of about 66,883 (257)

Clinical Insights Into Novel Immune Checkpoint Inhibitors

Frontiers in Pharmacology, 2021
The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1), and programmed death ligand-1 (PD-L1), has revolutionized treatment options ...
Jii Bum Lee, Jii Bum Lee, Sang-Jun Ha, Hye Ryun Kim   +3 more
doaj   +1 more source

Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification

Journal for ImmunoTherapy of Cancer, 2019
Background Permanence of front-line management of lung cancer by immunotherapies requires predictive companion diagnostics identifying immune-checkpoints at baseline, challenged by the size and heterogeneity of biopsy specimens.
Anne Monette, Derek Bergeron, Amira Ben Amor, Liliane Meunier, Christine Caron, Anne-Marie Mes-Masson, Nidhameddine Kchir, Kamel Hamzaoui, Igor Jurisica, Réjean Lapointe   +9 more
doaj   +1 more source

Immune Checkpoints in Solid Organ Transplantation

Biology, 2023
Allogenic graft acceptance is only achieved by life-long immunosuppression, which comes at the cost of significant toxicity. Clinicians face the challenge of adapting the patients’ treatments over long periods to lower the risks associated with these ...
Arnaud Del Bello, Emmanuel Treiner
doaj   +1 more source

Immune checkpoint blockade in HIV

eBioMedicine, 2022
Antiretroviral therapy (ART) has dramatically improved life expectancy for people with HIV (PWH) and helps to restore immune function but is not curative and must be taken lifelong. Achieving long term control of HIV in the absence of ART will likely require potent T cell function, but chronic HIV infection is associated with immune exhaustion that ...
Gubser, C, Chiu, C, Lewin, SR, Rasmussen, TA   +3 more
openaire   +5 more sources

A novel immune checkpoints-based signature to predict prognosis and response to immunotherapy in lung adenocarcinoma

Journal of Translational Medicine, 2022
Background Except for B7-CD28 family members, more novel immune checkpoints are being discovered. They are closely associated with tumor immune microenvironment and regulate the function of many immune cells.
Nan Sun, Yuejun Luo, Bo Zheng, Zhihui Zhang, Chaoqi Zhang, Zhen Zhang, Guochao Zhang, Fengwei Tan, Qi Xue, Shugeng Gao, Jie He   +10 more
doaj   +1 more source

The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers

Biomolecules, 2022
The Epstein-Barr Virus (EBV) is a gammaherpesvirus involved in the etiopathogenesis of a variety of human cancers, mostly of lymphoid and epithelial origin. The EBV infection participates in both cell transformation and tumor progression, also playing an
Alison Felipe Bordini Biggi, Deilson Elgui de Oliveira   +1 more
doaj   +1 more source

Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma

Cancer Biology & Medicine, 2020
In the interaction between a tumor and the immune system, immune checkpoints play an important role, and in tumor immune escape, co-inhibitory immune checkpoints are important.
Shaoping Shen, Ling Chen, Jialin Liu, Lin Yang, Mengna Zhang, Lingxiong Wang, Rong Zhang, Yasushi Uemura, Qiyan Wu, Xinguang Yu, Tianyi Liu   +10 more
doaj   +1 more source

Immune Checkpoint Inhibitor Toxicities [PDF]

Mayo Clinic Proceedings, 2019
Immune checkpoint inhibitors are molecules that increase the endogenous immune response against tumors. They have revolutionized the field of oncology. Since their initial approval for the treatment of advanced melanoma, their use has expanded to the treatment of several other advanced cancers. Unfortunately, immune checkpoint inhibitors have also been
Julian A. Marin-Acevedo, Razvan M. Chirila, Roxana S. Dronca   +2 more
openaire   +2 more sources

IgG Titer of Pfizer BNT62b2 COVID-19 Negatively Correlated with Soluble Inhibitory Immune Checkpoints

The Iraqi Journal of Medical Sciences
Background: The Corona virus disease 2019 (COVID-19) is a complicated respiratory syndrome caused by novel Corona virus that spread swiftly throughout the world.
Selda Ezzaldeen, Haider Kadhim, Mohammed Tawfiq   +2 more
doaj   +3 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source