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IL-18-Mediated Tumor Immune Evasion [PDF]

Current Issues in Molecular Biology
Immune response evasion is one of the hallmark features of cancer, which is not only the basis for cancer progression and metastasis but also affects the clinical management of cancer.
Shuai Li, Chenxia Gao, Hongyu Zhao, Didi Wang, Shuang Liu   +4 more
doaj   +2 more sources

The Role of Raf Kinase Inhibitor Protein (RKIP) in HER2+ Breast Cancer Immune Evasion [PDF]

Cells
Breast cancer (BC) is a prevalent malignancy worldwide among women. HER2 overexpression in a subset of BC (HER2+ BC) serves as a critical oncogenic driver and contributes to immune evasion. The Raf Kinase Inhibitor Protein (RKIP), a metastasis suppressor
Ania Khachikian, Mai Ho, Benjamin Bonavida   +2 more
doaj   +2 more sources

The immune evasion ability of Delta variant is comparable to that of Beta variant in South Africa

BMC Public Health, 2023
Background The high immune evasion ability of SARS-COV-2 Omicron variant surprised the world and appears to be far stronger than any previous variant.
Daihai He, Boqiang Chen, Shi Zhao, Lewi Stone   +3 more
doaj   +1 more source

Intrinsic immune evasion patterns predict temozolomide sensitivity and immunotherapy response in lower-grade gliomas

BMC Cancer, 2022
Background Although intrinsic immune-evasion is important in cancer proliferation, metastasis and response to treatment, it is unclear whether intrinsic immune-evasion patterns of gliomas can aid in predicting clinical prognosis and determining treatment.
Zewei Tu, Qiankun Ji, Qing Han, Xiaoyan Long, Jingying Li, Lei Wu, Kai Huang, Xingen Zhu   +7 more
doaj   +1 more source

The mechanisms on evasion of anti-tumor immune responses in gastric cancer

Frontiers in Oncology, 2022
The immune system and the tumor have been at each other’s throats for so long that the neoplasm has learned to avoid detection and avoid being attacked, which is called immune evasion.
Junyang Wang, Tong Liu, Tao Huang, Mei Shang, Xudong Wang   +4 more
doaj   +1 more source

Extrachromosomal DNA formation enables tumor immune escape potentially through regulating antigen presentation gene expression

Scientific Reports, 2022
Extrachromosomal DNA (ecDNA) is a type of circular and tumor specific genetic element. EcDNA has been reported to display open chromatin structure, facilitate oncogene amplification and genetic material unequal segregation, and is associated with poor ...
Tao Wu, Chenxu Wu, Xiangyu Zhao, Guangshuai Wang, Wei Ning, Ziyu Tao, Fuxiang Chen, Xue-Song Liu   +7 more
doaj   +1 more source

Evasion of the Cell-Mediated Immune Response by Alphaherpesviruses

Viruses, 2020
Alphaherpesviruses cause various diseases and establish life-long latent infections in humans and animals. These viruses encode multiple viral proteins and miRNAs to evade the host immune response, including both innate and adaptive immunity ...
Naoto Koyanagi, Yasushi Kawaguchi
doaj   +1 more source

In silico structural homology modeling and functional characterization of Mycoplasma gallisepticum variable lipoprotein hemagglutin proteins

Frontiers in Veterinary Science, 2022
Mycoplasma gallisepticum variable lipoprotein hemagglutin (vlhA) proteins are crucial for immune evasion from the host cells, permitting the persistence and survival of the pathogen.
Susithra Priyadarshni Mugunthan, Mani Chandra Harish   +1 more
doaj   +1 more source

Staphylococcus aureus uses the ArlRS and MgrA cascade to regulate immune evasion during skin infection

Cell Reports, 2021
Summary: Skin is one of the most common sites of host immune response against Staphylococcus aureus infection. Here, through a combination of in vitro assays, mouse models, and intravital imaging, we find that S.
Jakub M. Kwiecinski, Rachel M. Kratofil, Corey P. Parlet, Bas G.J. Surewaard, Paul Kubes, Alexander R. Horswill   +5 more
doaj   +1 more source

Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease

Brazilian Journal of Medical and Biological Research, 2011
Infection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system.
G.A. DosReis
doaj   +3 more sources