Results 1 to 10 of about 1,940,572 (373)
Overcoming immune evasion with innovative multi-target approaches for glioblastoma [PDF]
Frontiers in ImmunologyGlioblastoma (GBM) cells leverage complex endogenous and environmental regulatory mechanisms to drive proliferation, invasion, and metastasis. Tumor immune evasion, facilitated by a multifactorial network, poses a significant challenge to effective ...
Hai Su +5 more
doaj +2 more sources
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I
Nature, 2020 Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion include impaired antigen presentation caused by mutations or loss of heterozygosity of the major histocompatibility complex class I (MHC-I), which has been implicated ...
Keisuke Yamamoto +2 more
exaly +2 more sources
Immune Evasion Mechanism and AXL
Frontiers in Oncology, 2021 Extensive interest in cancer immunotherapy is reported according to the clinical importance of CTLA-4 and (PD-1/PD-L1) [programmed death (PD) and programmed death-ligand (PD-L1)] in immune checkpoint therapies. AXL is a receptor tyrosine kinase expressed
Hye-Youn Son, Hwan-Kyu Jeong
doaj +3 more sources
VISTA-mediated immune evasion in cancer [PDF]
Experimental and Molecular MedicineOver the past decade, V-domain immunoglobulin suppressor of T-cell activation (VISTA) has been established as a negative immune checkpoint molecule. Since the role of VISTA in inhibiting T-cell activation was described, studies have demonstrated other ...
Raymond J. Zhang, Tae Kon Kim
doaj +2 more sources
circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation
Advanced Science, 2021 Cancer stemness and immune evasion are closely associated, and play critical roles in tumor development and resistance to immunotherapy. However, little is known about the underlying molecular mechanisms that coordinate this association.
Cun-yu Wang
exaly +2 more sources
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron
Cell, 2022 Zhen Cui, Nan Wang, Kaiyue Fan
exaly +2 more sources
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
Cell Metabolism, 2022 Dong Guo +15 more
exaly +2 more sources
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion
Nature, 2021 The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B ...
P. Mlcochova +51 more
semanticscholar +1 more source
MedComm, 2023 As the fifth variant of concern of the SARS‐CoV‐2 virus, the Omicron variant (B.1.1.529) has quickly become the dominant type among the previous circulating variants worldwide.
Danyi Ao +3 more
semanticscholar +1 more source
Innate immune evasion strategies of SARS-CoV-2
Nature Reviews Microbiology, 2023 In this Review, Minkoff and tenOever examine the relationship between SARS-CoV-2 biology and innate immunity, and they explore how antagonism and dysregulation of host innate immune defences contribute to COVID-19 disease severity.
Judith M. Minkoff, B. tenOever
semanticscholar +1 more source