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Immune Evasion Mechanism and AXL [PDF]

open access: yesFrontiers in Oncology, 2021
Extensive interest in cancer immunotherapy is reported according to the clinical importance of CTLA-4 and (PD-1/PD-L1) [programmed death (PD) and programmed death-ligand (PD-L1)] in immune checkpoint therapies. AXL is a receptor tyrosine kinase expressed
Hye-Youn Son, Hwan-Kyu Jeong
exaly   +5 more sources

Overcoming immune evasion with innovative multi-target approaches for glioblastoma [PDF]

open access: yesFrontiers in Immunology
Glioblastoma (GBM) cells leverage complex endogenous and environmental regulatory mechanisms to drive proliferation, invasion, and metastasis. Tumor immune evasion, facilitated by a multifactorial network, poses a significant challenge to effective ...
Hai Su   +5 more
doaj   +2 more sources

Unraveling the immune evasion mechanisms in the tumor microenvironment of head and neck squamous cell carcinoma [PDF]

open access: yesFrontiers in Immunology
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy characterized by a complex tumor microenvironment (TME) that plays a pivotal role in tumor initiation, progression, and immune evasion.
Xuri Zhao   +7 more
doaj   +2 more sources

VISTA-mediated immune evasion in cancer [PDF]

open access: yesExperimental and Molecular Medicine
Over the past decade, V-domain immunoglobulin suppressor of T-cell activation (VISTA) has been established as a negative immune checkpoint molecule. Since the role of VISTA in inhibiting T-cell activation was described, studies have demonstrated other ...
Raymond J. Zhang, Tae Kon Kim
doaj   +2 more sources

The immune evasion ability of Delta variant is comparable to that of Beta variant in South Africa

open access: yesBMC Public Health, 2023
Background The high immune evasion ability of SARS-COV-2 Omicron variant surprised the world and appears to be far stronger than any previous variant.
Daihai He   +3 more
doaj   +1 more source

Intrinsic immune evasion patterns predict temozolomide sensitivity and immunotherapy response in lower-grade gliomas

open access: yesBMC Cancer, 2022
Background Although intrinsic immune-evasion is important in cancer proliferation, metastasis and response to treatment, it is unclear whether intrinsic immune-evasion patterns of gliomas can aid in predicting clinical prognosis and determining treatment.
Zewei Tu   +7 more
doaj   +1 more source

Evasion of the Cell-Mediated Immune Response by Alphaherpesviruses

open access: yesViruses, 2020
Alphaherpesviruses cause various diseases and establish life-long latent infections in humans and animals. These viruses encode multiple viral proteins and miRNAs to evade the host immune response, including both innate and adaptive immunity ...
Naoto Koyanagi, Yasushi Kawaguchi
doaj   +1 more source

Extrachromosomal DNA formation enables tumor immune escape potentially through regulating antigen presentation gene expression

open access: yesScientific Reports, 2022
Extrachromosomal DNA (ecDNA) is a type of circular and tumor specific genetic element. EcDNA has been reported to display open chromatin structure, facilitate oncogene amplification and genetic material unequal segregation, and is associated with poor ...
Tao Wu   +7 more
doaj   +1 more source

The mechanisms on evasion of anti-tumor immune responses in gastric cancer

open access: yesFrontiers in Oncology, 2022
The immune system and the tumor have been at each other’s throats for so long that the neoplasm has learned to avoid detection and avoid being attacked, which is called immune evasion.
Junyang Wang   +4 more
doaj   +1 more source

In silico structural homology modeling and functional characterization of Mycoplasma gallisepticum variable lipoprotein hemagglutin proteins

open access: yesFrontiers in Veterinary Science, 2022
Mycoplasma gallisepticum variable lipoprotein hemagglutin (vlhA) proteins are crucial for immune evasion from the host cells, permitting the persistence and survival of the pathogen.
Susithra Priyadarshni Mugunthan   +1 more
doaj   +1 more source

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