Results 11 to 20 of about 1,940,572 (373)

Human Herpesviridae Methods of Natural Killer Cell Evasion [PDF]

Advances in Virology, 2012
Human herpesviruses cause diseases of considerable morbidity and mortality, ranging from encephalitis to hematologic malignancies. As evidence emerges about the role of innate immunity and natural killer (NK) cells in the control of herpesvirus infection,
Carl I. Odom, David C. Gaston, James M. Markert, Kevin A. Cassady   +3 more
doaj   +3 more sources

How the other half lives: CRISPR-Cas's influence on bacteriophages [PDF]

Evolutionary Biology : Self, Non-Self Evolution, Species and Complex Traits, Evolution, Methods and Concepts, ISBN 978-3-319-61569-1, edited by Pierre Pontarotti, Springer Nature, September 2017, pp. 63-85, 2017
CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers. These spacers are expressed as mobile surveillance RNAs that direct CRISPR-associated (Cas) proteins to protect ...
AE Briner, AF Andersson, BR Levin, C Pourcel, CL Sun, D Bhaya, E Pennisi, E Scarpellini, EV Koonin, FS Berezovskaya, GW Tyson, H Deveau, H Deveau, I Yosef, IN Berezovsky, J He, J Iranzo, J Mahony, JF Heidelberg, JM Peters, JO Haerter, KD Seed, KL Maxwell, LA Marraffini, LM Childs, M Sebaihia, P Han, P Horvath, P Horvath, PD Hsu, R Barrangou, R Lillestøl, R Sorek, S Al-Attar, S Minot, W Jiang   +35 more
arxiv   +3 more sources

Telomeric expression sites are highly conserved in trypanosoma brucei [PDF]

, 2008
Subtelomeric regions are often under-represented in genome sequences of eukaryotes. One of the best known examples of the use of telomere proximity for adaptive purposes are the bloodstream expression sites (BESs) of the African trypanosome Trypanosoma ...
Andrew Jackson, AP Jackson, Brian White, Carol Churcher, Christiane Hertz-Fowler, D Horn, D Salmon, Danielle Walker, David Harris, David Saunders, E Pays, E Pays, E Pays, E Wirtz, Edward J. Louis, FE Pryde, G Rudenko, G Rudenko, G Rudenko, George A. M. Cross, Gloria Rudenko, GS Lamont, H Hirumi, H Shimodaira, HC Mefford, Heidi Hauser, HG van Luenen, HV Xong, I Ansorge, Ian Goodhead, IC Florent, J. David Barry, JD Barry, JD Thompson, JE Haber, Jesse E. Taylor, JG Johnson, K Rutherford, K Scheffler, K Sheader, Karen Brooks, Karen Mungall, Kathy Seeger, KM Gottesdiener, KM Gottesdiener, L Marcello, L Vanhamme, Luisa M. Figueiredo, M Becker, M Berriman, M Berriman, M Cross, M Hoek, M Hoek, M Navarro, Magdalena Kartvelishvili, Mandy Sanders, Marion Becker, Matthew Berriman, MB Redpath, Michael A. Quail, MJ Ligtenberg, N Aitcheson, Nathalie Bason, ND Fedorova, Neil Hall, O Dreesen, O Dreesen, P Paindavoine, P Rice, Paul Heath, PJ Myler, RL Barnes, Rosanna Young, RW Morgan, S Callejas, S Guindon, Samah Fahkro, Sarah Sharp, SE Melville, SE Melville, SL Kosakovsky Pond, SL Pond, TC Bruen, V Leech, VB Carruthers, WS Wong   +86 more
core   +11 more sources

O-GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Two important features for cancer are the addiction to nutrients such as glucose, and the ability to escape immune clearance. How these two features are connected is poorly understood.
Qian Zhu, Hongxing Wang, S. Chai, Liang Xu, Bing-ying Lin, Wen Yi, Liming Wu   +6 more
semanticscholar   +1 more source

The immune evasion ability of Delta variant is comparable to that of Beta variant in South Africa

BMC Public Health, 2023
Background The high immune evasion ability of SARS-COV-2 Omicron variant surprised the world and appears to be far stronger than any previous variant.
Daihai He, Boqiang Chen, Shi Zhao, Lewi Stone   +3 more
doaj   +1 more source

Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation

Nature Communications, 2023
The recently described role of RNA methylation in regulating immune cell infiltration into tumors has attracted interest, given its potential impact on immunotherapy response.
Wanzun Lin, Li Chen, Haojiong Zhang, Xianxin Qiu, Qingting Huang, Fangzhu Wan, Z. Le, Shikai Geng, Anlan Zhang, S. Qiu, Long Chen, L. Kong, Jiade J. Lu   +12 more
semanticscholar   +1 more source

Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma

Frontiers in Immunology, 2023
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is the third leading cause of tumor-related mortality worldwide. In recent years, the emergency of immune checkpoint inhibitor (ICI) has revolutionized the management of HCC ...
Chen Chen, Zehua Wang, Y. Ding, Y.Y. Qin
semanticscholar   +1 more source

Cytomegalovirus immune evasion sets the functional avidity threshold for protection by CD8 T cells [PDF]

, 2022
Conflicting hallmarks are attributed to cytomegalovirus (CMV) infections. CMVs are viewed as being master tacticians in “immune evasion” by subverting essentially all pathways of innate and adaptive immunity.
Hamdan, Sara, Holtappels, Rafaela, Reddehase, Matthias J.   +2 more
core   +1 more source

m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion

Molecular Cancer, 2023
N6-methyladenosine (m^6A) methylation is the most universal internal modification in eukaryotic mRNA. With elaborate functions executed by m^6A writers, erasers, and readers, m^6A modulation is involved in myriad physiological and pathological processes.
Xiaoxue Cao, Qishun Geng, Danping Fan, Qiong Wang, Xing Wang, Mengxiao Zhang, Lu Zhao, Yi Jiao, Tingting Deng, Hong-lin Liu, Jing Zhou, L. Jia, Cheng Xiao   +12 more
semanticscholar   +1 more source

Stage-Specific Inhibition of MHC Class I Presentation by the Epstein-Barr Virus BNLF2a Protein during Virus Lytic Cycle [PDF]

, 2009
gamma-herpesvirus Epstein-Barr virus (EBV) persists for life in infected individuals despite the presence of a strong immune response. During the lytic cycle of EBV many viral proteins are expressed, potentially allowing virally infected cells to be ...
A Rickinson, AD Hislop, AD Hislop, Alan B. Rickinson, Andrew D. Hislop, Andrew I. Bell, B Park, Bill Sugden, BJ Biegalke, BN Lilley, C Bogedain, Claire Shannon-Lowe, Daniëlle Horst, DJ Tenney, E Scotet, Elisabeth Kremmer, Emmanuel J. H. J. Wiertz, G Lautscham, HJ Delecluse, J Yuan, J Zuo, J Zuo, Jaap M. Middeldorp, JC Stinchcombe, JW Yewdell, JX Zhang, K Takada, L Young, LS Young, M Buisson, M Kishishita, M Rowe, Maaike E. Ressing, Martin Rowe, MC Gold, ME Ressing, MT Vossen, MW Munks, Nathan P. Croft, NM Steven, P Rivailler, PG Stevenson, R Feederle, S Keating, TA Groothuis, TR Jones, TR Jones, V Bohm, VA Pudney, WM van Grunsven, X Saulquin, Y Zeng   +51 more
core   +21 more sources