Targeting PIM Kinases to Improve the Efficacy of Immunotherapy
Cells, 2022 The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of serine/threonine kinases that regulates numerous signaling networks that promote cell growth, proliferation, and survival.
Amber N. Clements, Noel A. Warfel
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Lymphoma: Immune Evasion Strategies [PDF]
Cancers, 2015 While the cellular origin of lymphoma is often characterized by chromosomal translocations and other genetic aberrations, its growth and development into a malignant neoplasm is highly dependent upon its ability to escape natural host defenses.
Upadhyay, Ranjan +5 more
openaire +2 more sources
Testing the theory of immune selection in cancers that break the rules of transplantation [PDF]
, 2009 Modification of cancer cells likely to reduce their immunogenicity, including loss or down-regulation of MHC molecules, is now well documented and has become the main support for the concept of immune surveillance.
A Garcia-Lora +84 more
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Immune Evasion of Mycoplasma bovis
Pathogens, 2021 Mycoplasma bovis (M. bovis) causes various chronic inflammatory diseases, including mastitis and bronchopneumonia, in dairy and feed cattle. It has been found to suppress the host immune response during infection, leading to the development of chronic ...
Hussam Askar +6 more
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Lactate signalling regulates fungal β-glucan masking and immune evasion [PDF]
, 2016 AJPB: This work was supported by the European Research Council (STRIFE, ERC- 2009-AdG-249793), The UK Medical Research Council (MR/M026663/1), the UK Biotechnology and Biological Research Council (BB/K017365/1), the Wellcome Trust (080088; 097377).
A Hopke +50 more
core +1 more source
Modulation of the host Th1 immune response in pigeon protozoal encephalitis caused by Sarcocystis calchasi [PDF]
, 2013 Pigeon protozoal encephalitis (PPE) is an emerging central-nervous disease of domestic pigeons (Columba livia f. domestica) reported in Germany and the United States.
Gruber, Achim D. +5 more
core +3 more sources
NKG2D and its ligands: one for all, all for one [PDF]
, 2018 The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal cells but can be induced on damaged, transformed or infected cells, with ...
Cerboni, Cristina +7 more
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Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region [PDF]
, 2017 The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases.
De Pablos, Luis Miguel +5 more
core +3 more sources
Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G [PDF]
, 2009 Background: The activating immunoreceptor NKG2D is expressed on Natural Killer (NK) cells and subsets of T cells. NKG2D contributes to anti-tumour and anti-viral immune responses in vitro and in vivo. The ligands for NKG2D in humans are diverse proteins
A Cerwenka +67 more
core +11 more sources
Immune subtypes and neoantigen-related immune evasion in advanced colorectal cancer
iScience, 2022 Summary: Elimination of cancerous cells by the immune system is an important mechanism of protection from cancer, however, its effectiveness can be reduced owing to development of resistance and evasion.
Toshitaka Sugawara +11 more
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