Results 21 to 30 of about 121,779 (302)

Targeting PIM Kinases to Improve the Efficacy of Immunotherapy

Cells, 2022
The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of serine/threonine kinases that regulates numerous signaling networks that promote cell growth, proliferation, and survival.
Amber N. Clements, Noel A. Warfel
doaj   +1 more source

Predictive Virtual Infection Modeling of Fungal Immune Evasion in Human Whole Blood

Frontiers in Immunology, 2018
Bloodstream infections by the human-pathogenic fungi Candida albicans and Candida glabrata increasingly occur in hospitalized patients and are associated with high mortality rates.
Maria T. E. Prauße, Maria T. E. Prauße, Teresa Lehnert, Teresa Lehnert, Sandra Timme, Sandra Timme, Kerstin Hünniger, Kerstin Hünniger, Ines Leonhardt, Ines Leonhardt, Oliver Kurzai, Oliver Kurzai, Oliver Kurzai, Marc Thilo Figge, Marc Thilo Figge, Marc Thilo Figge   +15 more
doaj   +1 more source

Innate immune evasion by picornaviruses [PDF]

European Journal of Immunology, 2020
AbstractThe family Picornaviridae comprises a large number of viruses that cause disease in broad spectrum of hosts, which have posed serious public health concerns worldwide and led to significant economic burden. A comprehensive understanding of the virus‐host interactions during picornavirus infections will help to prevent and cure these diseases ...
Haixue Zheng, Max Paget, Max Paget, Zixiang Zhu, Xiangle Zhang, Congcong Wang   +5 more
openaire   +2 more sources

Immune Evasion of G-CSF and GM-CSF in Lung Cancer [PDF]

Tuberculosis and Respiratory Diseases
Tumor immune evasion is a complex process that involves various mechanisms, such as antigen recognition restriction, immune system suppression, and T cell exhaustion.
Yeonhee Park, Chaeuk Chung
doaj   +1 more source

Lymphoma: Immune Evasion Strategies [PDF]

Cancers, 2015
While the cellular origin of lymphoma is often characterized by chromosomal translocations and other genetic aberrations, its growth and development into a malignant neoplasm is highly dependent upon its ability to escape natural host defenses.
Brian D. Brown, Ranjan Upadhyay, Joshua Brody, Linda Hammerich, Paul Peng, Miriam Merad   +5 more
openaire   +2 more sources

Neuroimmune Evasion of Zika Virus to Facilitate Viral Pathogenesis

Frontiers in Cellular and Infection Microbiology, 2021
Zika virus (ZIKV), which preferentially targets neural stem and progenitor cells (NSCs) especially in developing brain, is causally associated with fetal microcephaly, intrauterine retardation, and other congenital malformations in humans. However, there
Xiaochun Xie, Jianxiong Zeng, Jianxiong Zeng, Jianxiong Zeng   +3 more
doaj   +1 more source

Subversion of Immune Response by Human Cytomegalovirus

Frontiers in Immunology, 2019
Human cytomegalovirus (HCMV) is the most common cause of congenital infections and is an important pathogen in immunocompromised individuals. Despite a robust host immune system, HCMV able to replicate, evade host defenses, establish latency for life.
A. Raj Kumar Patro
doaj   +1 more source

Histone Methyltransferase SETDB1 Promotes Immune Evasion in Colorectal Cancer via FOSB-Mediated Downregulation of MicroRNA-22 through BATF3/PD-L1 Pathway

Journal of Immunology Research, 2022
Tumors may develop a variety of immune evasion mechanisms during the progression of colorectal cancer (CRC). Here, we intended to explore the mechanism of histone methyltransferase SETDB1 in immune evasion in CRC.
Jiale Tian, Weiwei Wang, Jichao Zhu, Yun Zhuang, Chunrun Qi, Zhengxin Cai, Wenhui Yan, Wenying Lu, Anquan Shang   +8 more
doaj   +1 more source

Nanotechnology-Based siRNA Delivery Systems to Overcome Tumor Immune Evasion in Cancer Immunotherapy

Pharmaceutics, 2022
Immune evasion is a common reason causing the failure of anticancer immune therapy. Small interfering RNA (siRNA), which can activate the innate and adaptive immune system responses by silencing immune-relevant genes, have been demonstrated to be a ...
Kaili Deng, Dongxue Yang, Yuping Zhou
doaj   +1 more source

Engineering immune evasion [PDF]

Nature, 2006
One obstacle to realizing the promise of viral vectors for vaccine delivery is pre-existing immunity to such vectors. An adroit application of structure-based design points to a way around that problem.
openaire   +2 more sources