Results 31 to 40 of about 121,779 (302)
Immune Evasion, Immunopathology and the Regulation of the Immune System [PDF]
Pathogens, 2013 Costs and benefits of the immune response have attracted considerable attention in the last years among evolutionary biologists. Given the cost of parasitism, natural selection should favor individuals with the most effective immune defenses. Nevertheless, there exists huge variation in the expression of immune effectors among individuals.
Sorci, Gabriele +2 more
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Annual Review of ImmunologyPoxviruses have evolved a wide array of mechanisms to evade the immune response, and we provide an overview of the different immunomodulatory strategies. Poxviruses prevent the recognition of viral DNA that triggers the immune responses and inhibit signaling pathways within the infected cell. A unique feature of poxviruses is the production of secreted
Hernáez, Bruno, Alcamí, Antonio
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Nature Reviews Cancer, 2018 Three recent papers have shed light on how the common oncogenic drivers MYC and RAS can induce an immunosuppressive tumour microenvironment.
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Do Tumor Mechanical Stresses Promote Cancer Immune Escape?
Cells, 2022 Immune evasion—a well-established cancer hallmark—is a major barrier to immunotherapy efficacy. While the molecular mechanisms and biological consequences underpinning immune evasion are largely known, the role of tissue mechanical stresses in these ...
Killian Onwudiwe +3 more
doaj +1 more source
Unveiling the stealthy tactics: mycoplasma’s immune evasion strategies
Frontiers in Cellular and Infection Microbiology, 2023 Mycoplasmas, the smallest known self-replicating organisms, possess a simple structure, lack a cell wall, and have limited metabolic pathways. They are responsible for causing acute or chronic infections in humans and animals, with a significant number ...
Jingyun Wang +7 more
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FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
Genetically Modified T-Cell-Based Adoptive Immunotherapy in Hematological Malignancies
Journal of Immunology Research, 2017 A significant proportion of hematological malignancies remain limited in treatment options. Immune system modulation serves as a promising therapeutic approach to eliminate malignant cells.
Baixin Ye +7 more
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eLife, 2023 The failure of cancer treatments, including immunotherapy, continues to be a major obstacle in preventing durable remission. This failure often results from tumor evolution, both genotypic and phenotypic, away from sensitive cell states. Here, we propose
Jason T George, Herbert Levine
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Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Human cytomegalovirus immunity and immune evasion
Virus Research, 2011 Human cytomegalovirus (HCMV) infection induces both innate immune responses including Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ cytotoxic and γδ T cell) responses which lead to the resolution of acute primary infection.
Mark R. Wills +2 more
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