Results 1 to 10 of about 2,585,977 (417)

Immune Infiltration and Prostate Cancer [PDF]

Frontiers in Oncology, 2015
It is becoming increasingly clear that inflammation influences prostate cancer (PCa) development and that immune cells are among the primary drivers of this effect. This information has launched numerous clinical trials testing immunotherapy drugs in PCa patients.
Strasner, Amy, Karin, Michael
core   +12 more sources

Barriers to immune cell infiltration in tumors

Journal for ImmunoTherapy of Cancer, 2023
Increased immune cell infiltration into tumors is associated with improved patient survival and predicts response to immune therapies. Thus, identification of factors that determine the extent of immune infiltration is crucial, so that methods to intervene on these targets can be developed. T cells enter tumor tissues through the vasculature, and under
Marit M Melssen, Natasha D Sheybani, Katie M Leick, Craig L Slingluff   +3 more
doaj   +5 more sources

Keloid Biomarkers and Their Correlation With Immune Infiltration

Frontiers in Genetics, 2022
Objective: This work aimed to verify the candidate biomarkers for keloid disorder (KD), and analyze the role of immune cell infiltration (ICI) in the pathology of keloid disorder.Methods: The keloid-related datasets (GSE44270 and GSE145725) were retrieved from the Gene Expression Omnibus (GEO).
Xufeng Yin, Wenbo Bu, Fang Fang, Kehui Ren, Bingrong Zhou   +4 more
openaire   +4 more sources

Immune infiltrating cells in duodenal cancers [PDF]

Journal of Translational Medicine, 2020
Abstract Background Duodenal adenocarcinoma (DA) is a rare yet aggressive malignancy, with increasing incidence in the last decades. Its low frequency has hampered a thorough understanding of the pathogenesis of the disease and of its biology, limiting the identification of tailored therapeutic options.
Donisi, G., Capretti, G., Cortese, N., Rigamonti, A., Gavazzi, F., Nappo, G., Pulvirenti A, Sollai, M., Spaggiari, P., Zerbi, A., Marchesi, F   +20 more
openaire   +5 more sources

Exploration of the Immune-Related Signatures and Immune Infiltration Analysis in Melanoma [PDF]

Analytical Cellular Pathology, 2021
In the present study, we aimed to investigate immune-related signatures and immune infiltration in melanoma. The transcriptome profiling and clinical data of melanoma were downloaded from The Cancer Genome Atlas database, and their matched normal samples were obtained from the Genotype-Tissue Expression database.
Ai-lan Li, Yong-mei Zhu, Lai-qiang Gao, Shu-yue Wei, Ming-tao Wang, Qiang Ma, You-you Zheng, Jian-hua Li, Qing-feng Wang   +8 more
openaire   +3 more sources

Immune infiltrate in cancer [PDF]

Aging, 2015
The past decade has witnessed a major revolution in cancer research. While malignancy was (and is) generally considered as a cell-autonomous genetic and epigenetic disease, it turned out that cancer has also an immunological connotation [1]. Only if the immune system fails to eliminate the (pre-)neoplastic cells cancer can emerge and progress.
Guido Kroemer, Gautier Stoll, Laurence Zitvogel   +2 more
openaire   +2 more sources

Cdx2 regulates immune cell infiltration in the intestine [PDF]

Scientific Reports, 2021
AbstractThe intestinal epithelium is a unique tissue, serving both as a barrier against pathogens and to conduct the end digestion and adsorption of nutrients. As regards the former, the intestinal epithelium contains a diverse repertoire of immune cells, including a variety of resident lymphocytes, macrophages and dendritic cells.
David Lohnes, Simon Chewchuk, Sanzida Jahan   +2 more
openaire   +4 more sources

Immune Cell Infiltrate and Prognosis in Gastric Cancer [PDF]

Cancers, 2020
Purpose: To examine and compare the prognostic value of immune cell score (ICS) and Klintrup–Mäkinen (KM) grade in gastric cancer. Methods: Gastric adenocarcinoma tissues from samples of 741 patients surgically treated in two hospitals in Finland were assessed for ICS and KM grade.
Anna Junttila, Joni Leppänen, Joonas H. Kauppila, Joonas H. Kauppila, Heikki Huhta, Tuomo J. Karttunen, Johanna Mrena, Niko Hiltunen, Vesa-Matti Pohjanen, Jan Böhm, Niko Kemi, Juha P. Väyrynen, Olli Helminen   +12 more
openaire   +3 more sources

Immune infiltration in renal cell carcinoma [PDF]

Cancer Science, 2019
Immune infiltration of tumors is closely associated with clinical outcome in renal cell carcinoma (RCC). Tumor‐infiltrating immune cells (TIICs) regulate cancer progression and are appealing therapeutic targets. The purpose of this study was to determine the composition of TIICs in RCC and further reveal the independent prognostic values of TIICs ...
Shichao Zhang, Erdong Zhang, Jinhua Long, Zuquan Hu, Jian Peng, Lina Liu, Fuzhou Tang, Long Li, Yan Ouyang, Zhu Zeng   +9 more
openaire   +3 more sources

DFNA5 regulates immune cells infiltration and exhaustion [PDF]

Cancer Cell International, 2022
Abstract Background DFNA5 (GSDME) belongs to Gasdermin familily that is involved in a variety of cancers and triggers cell pyroptosis after chemical treatment. However, the relationship in DFNA5 between prognosis and immune cells in diverse cancers has been receiving little attention.
Jian Hu, Wenceng Pei, Minren Jiang, Ying Huang, Fuyun Dong, Zhenyou Jiang, Ying Xu, Zihuang Li   +7 more
openaire   +3 more sources