Results 1 to 10 of about 662,585 (256)

Immune infiltration and prostate cancer [PDF]

Frontiers in Oncology, 2015
It is becoming increasingly clear that inflammation influences prostate cancer development and that immune cells are among the primary drivers of this effect.
Amy eStrasner, Michael eKarin
doaj   +10 more sources

Barriers to immune cell infiltration in tumors

Journal for ImmunoTherapy of Cancer, 2023
Increased immune cell infiltration into tumors is associated with improved patient survival and predicts response to immune therapies. Thus, identification of factors that determine the extent of immune infiltration is crucial, so that methods to ...
Craig L Slingluff, Marit M Melssen, Natasha D Sheybani, Katie M Leick   +3 more
doaj   +3 more sources

Macrophage depletion disrupts immune balance and energy homeostasis. [PDF]

, 2014
Increased macrophage infiltration in tissues including white adipose tissue and skeletal muscle has been recognized as a pro-inflammatory factor that impairs insulin sensitivity in obesity.
Feng, Gen-Sheng, Kinney, Brice, Lee, Bonggi, Qiao, Liping, Shao, Jianhua   +4 more
core   +16 more sources

Integrated single cell and bulk sequencing analysis identifies tumor reactive CXCR6+ CD8 T cells as a predictor of immune infiltration and immunotherapy outcomes in hepatocellular carcinoma

Frontiers in Oncology, 2023
BackgroundVarious immune cell types in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) have been identified as important parameters associated with prognosis and responsiveness to immunotherapy.
Xiaogang Li, Xiaogang Li, Zheng Gao, Zheng Gao, Jiafeng Chen, Jiafeng Chen, Shanru Feng, Shanru Feng, Xuanming Luo, Yinghong Shi, Yinghong Shi, Zheng Tang, Zheng Tang, Weiren Liu, Weiren Liu, Xin Zhang, Xin Zhang, Ao Huang, Ao Huang, Qiang Gao, Qiang Gao, Aiwu Ke, Aiwu Ke, Jian Zhou, Jian Zhou, Jian Zhou, Jia Fan, Jia Fan, Xiutao Fu, Xiutao Fu, Zhenbin Ding, Zhenbin Ding, Zhenbin Ding   +32 more
doaj   +1 more source

Development of an Immune-Related Gene Signature for Prognosis in Melanoma

Frontiers in Oncology, 2021
Melanoma remains a potentially deadly malignant tumor. The incidence of melanoma continues to rise. Immunotherapy has become a new treatment method and is widely used in a variety of tumors. Original melanoma data were downloaded from TCGA.
Jia-An Zhang, Xu-Yue Zhou, Dan Huang, Chao Luan, Heng Gu, Mei Ju, Kun Chen   +6 more
doaj   +1 more source

Construction and validation of an immune infiltration-related risk model for predicting prognosis and immunotherapy response in low grade glioma

BMC Cancer, 2023
Background Low grade glioma (LGG) is considered a heterogeneous tumor with highly variable survival and limited efficacy of immunotherapy. To identify high-risk subsets and apply immunotherapy effectively in LGG, the status and function of immune ...
Jinna Li, Qing Guo, Rui Xing
doaj   +1 more source

Combined PD-1/PD-L1 and tumor-infiltrating immune cells redefined a unique molecular subtype of high-grade serous ovarian carcinoma

BMC Genomics, 2022
Background High-grade serous ovarian carcinoma is highly heterogeneous, and although many studies have been conducted to identify high-grade serous ovarian carcinoma molecular subtypes that are sensitive to immunotherapy, no precise molecular subtype has
Ping Liu, Ruoxu Chen, Xudong Zhang, Ruiting Fu, Lin Tao, Wei Jia   +5 more
doaj   +1 more source

Identification and Validation of Immune Infiltration Phenotypes in Laryngeal Squamous Cell Carcinoma by Integrative Multi-Omics Analysis

Frontiers in Immunology, 2022
BackgroundLaryngeal squamous cell carcinoma (LSCC) is one of the world’s most common head and neck cancer. However, the immune infiltration phenotypes of LSCC have not been well investigated.MethodsThe multi-omics data of LSCC were obtained from the TCGA
Li Yan, Xiaole Song, Gang Yang, Lifen Zou, Yi Zhu, Xiaoshen Wang   +5 more
doaj   +1 more source

Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer [PDF]

, 2020
Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response.
Chervoneva, Inna, Davis, Rachel, Gorenstein, David G, Hasan, Nafis, Hills, Natalie, Ichimura, Norihisa, Kameyama, Hiroyasu, Kondo, Yuji, Leslie, Macall, Lokesh, Ganesh L R, Morita, Yoshihiro, Rui, Hallgeir, Tanaka, Takemi, Volk, David E, Zhang, Roy   +14 more
core   +3 more sources

Spatially variant immune infiltration scoring in human cancer tissues

npj Precision Oncology, 2022
The Immunoscore is a method to quantify the immune cell infiltration within cancers to predict the disease prognosis. Previous immune profiling approaches relied on limited immune markers to establish patients’ tumor immunity.
Mayar Allam, Thomas Hu, Jeongjin Lee, Jeffrey Aldrich, Sunil S. Badve, Yesim Gökmen-Polar, Manali Bhave, Suresh S. Ramalingam, Frank Schneider, Ahmet F. Coskun   +9 more
doaj   +1 more source