Results 101 to 110 of about 2,772,829 (401)
Stromal score is a promising index in tumor patients’ outcome determination
Heliyon, 2023 Background: Immune status is widely acknowledged as a valuable marker for predicting cancer prognosis and therapy response. However, there has been a limited understanding of the stromal landscape in cancer.
Xiaoxian Xu +10 more
doaj +1 more source
Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. [PDF]
, 2019 Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the ...
Barton, Gregory M +11 more
core +1 more source
Cellular & Molecular Biology LettersBackground Septic cardiomyopathy (SCM), a common cardiovascular comorbidity of sepsis, has emerged among the leading causes of death in patients with sepsis.
Yukun Li +4 more
semanticscholar +1 more source
Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment
Frontiers in Immunology, 2021 Regulatory T cells (Tregs) are key immunosuppressive cells that promote tumor growth by hindering the effector immune response. Tregs utilize multiple suppressive mechanisms to inhibit pro-inflammatory responses within the tumor microenvironment (TME) by
E. Scott +3 more
semanticscholar +1 more source
Claudin-low bladder tumors are immune infiltrated and actively immune suppressed [PDF]
JCI Insight, 2016 We report the discovery of a claudin-low molecular subtype of high-grade bladder cancer that shares characteristics with the homonymous subtype of breast cancer. Claudin-low bladder tumors were enriched for multiple genetic features including increased rates of RB1, EP300, and NCOR1 mutations; increased frequency of EGFR amplification; decreased rates ...
Jordan, Kardos +10 more
openaire +2 more sources
TIMER2.0 for analysis of tumor-infiltrating immune cells [PDF]
Nucleic Acids Research, 2020 Abstract Tumor progression and the efficacy of immunotherapy are strongly influenced by the composition and abundance of immune cells in the tumor microenvironment. Due to the limitations of direct measurement methods, computational algorithms are often used to infer immune cell composition from bulk tumor transcriptome profiles.
X Shirley Liu +7 more
openaire +2 more sources
Frontiers in Immunology, 2022 Immunotherapy, closely associated with immune infiltration and tumor mutation burden (TMB), is emerging as a promising strategy for treating tumors, but its low response rate in hepatocellular carcinoma (HCC) remains a major challenge. Herein, we applied
Yuanyuan Guo +14 more
doaj +1 more source
The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]
, 2016 Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L. +6 more
core +1 more source
Tumor Burden and Immunotherapy: Impact on Immune Infiltration and Therapeutic Outcomes
Frontiers in Immunology, 2021 Cancer immunotherapy has revolutionized the treatment landscape in medical oncology, but its efficacy has been variable across patients. Biomarkers to predict such differential response to immunotherapy include cytotoxic T lymphocyte infiltration, tumor ...
Samuel I Kim +2 more
semanticscholar +1 more source
Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]
, 2014 Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
core +1 more source