Results 41 to 50 of about 662,585 (256)

Correlation analysis between immune-related genes and cell infiltration revealed prostate cancer immunotherapy biomarkers linked to T cells gamma delta

open access: yesScientific Reports, 2023
Prostate cancer (PCa) is a urological malignancy with poor prognosis. Immune-related genes are associated with immune infiltration in prostate cancer, but their role in immunogenic PCa is less well understood.
Wenkang Niu, Tingting Zhang, Lei Ma
doaj   +1 more source

Comprehensive characterization of enhancer RNA in hepatocellular carcinoma reveals three immune subtypes with implications for immunotherapy

open access: yesMolecular Therapy: Oncolytics, 2022
Hepatocellular carcinoma (HCC) is highly heterogeneous. Molecular subtyping for guiding immunotherapy is warranted. Previous studies have indicated that enhancer RNAs (eRNAs) are involved in tumor heterogeneity and immune infiltration.
Xiaoyun Bu   +6 more
doaj   +1 more source

Immune Characteristics in Biliary Atresia Based on Immune Genes and Immune Cell Infiltration

open access: yesFrontiers in Pediatrics, 2022
BackgroundBiliary atresia (BA) is a serious biliary disease in infancy. Jaundice is the most visual and prominent symptom, and it mainly involves bile duct cells leading to the loss of intrahepatic and extrahepatic bile ducts. If left untreated, it will eventually progress to liver cirrhosis. The pathogenesis of BA is not clear, and it is now generally
Chenyu Yang   +7 more
openaire   +3 more sources

Tumor Immune Microenvironment Characterization Identifies Prognosis and Immunotherapy-Related Gene Signatures in Melanoma

open access: yesFrontiers in Immunology, 2021
BackgroundThe tumor microenvironment (TME) involves infiltration of multiple immune cell subsets, which could influence the prognosis and clinical characteristics.
Dan Liu, Xue Yang, Xiongzhi Wu
doaj   +1 more source

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]

open access: yes, 2013
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
A Casadevall   +74 more
core   +3 more sources

Histopathological image QTL discovery of immune infiltration variants [PDF]

open access: yesiScience, 2017
AbstractGenotype-to-phenotype association studies typically use macroscopic physiological measurements or molecular readouts as quantitative traits. There are comparatively few suitable quantitative traits available between cell and tissue length scales, a limitation that hinders our ability to identify variants affecting phenotype at many clinically ...
Barry, Joseph D.   +5 more
openaire   +5 more sources

New insights from integrated bioinformatics analysis: the role of circadian rhythm disruption and immune infiltration in obstructive sleep apnea disease

open access: yesFrontiers in Immunology, 2023
BackgroundCircadian rhythm disruption and immune infiltration are both closely associated with the development of Obstructive sleep apnea (OSA) disease and a variety of cardiovascular and neurological complications, but their interactions with OSA ...
Xinyue Zhang   +3 more
doaj   +1 more source

Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha). [PDF]

open access: yes, 2009
Matrix metalloproteinases (MMPs) have a crucial function in migration of inflammatory cells into the central nervous system (CNS). Levels of MMP-9 are elevated in multiple sclerosis (MS) and predict the occurrence of new active lesions on magnetic ...
Du, Sienmi   +6 more
core   +3 more sources

Immune Landscape of Invasive Ductal Carcinoma Tumor Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature

open access: yesFrontiers in Oncology, 2019
Background: Invasive ductal carcinoma (IDC) is a clinically and molecularly distinct disease. Tumor microenvironment (TME) immune phenotypes play crucial roles in predicting clinical outcomes and therapeutic efficacy.Method: In this study, we depict the ...
Xuanwen Bao   +7 more
doaj   +1 more source

Immunonutrition before esophagectomy: Impact on immune surveillance mechanisms [PDF]

open access: yes, 2017
Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal ...
Agostini, Marco   +12 more
core   +1 more source

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