Results 51 to 60 of about 2,585,977 (417)

A Pragmatic Machine Learning Approach to Quantify Tumor Infiltrating Lymphocytes in Whole Slide Images [PDF]

Cancers, 14 (2022) 12, 2974, 2022
Increased levels of tumor infiltrating lymphocytes (TILs) in cancer tissue indicate favourable outcomes in many types of cancer. Manual quantification of immune cells is inaccurate and time consuming for pathologists. Our aim is to leverage a computational solution to automatically quantify TILs in whole slide images (WSIs) of standard diagnostic ...
arxiv   +1 more source

Comprehensive analysis of cuproptosis-related genes in immune infiltration and diagnosis in ulcerative colitis

Frontiers in Immunology, 2022
Objectives Cuproptosis is a recently discovered form of programmed cell death; however, its role in ulcerative colitis (UC) remains a void. Methods Three gene expression profiles were acquired from the GEO database.
Jinke Huang, Jiaqi Zhang, Fengyun Wang, Beihua Zhang, Xudong Tang   +4 more
semanticscholar   +1 more source

Macrophage depletion disrupts immune balance and energy homeostasis. [PDF]

, 2014
Increased macrophage infiltration in tissues including white adipose tissue and skeletal muscle has been recognized as a pro-inflammatory factor that impairs insulin sensitivity in obesity.
Feng, Gen-Sheng, Kinney, Brice, Lee, Bonggi, Qiao, Liping, Shao, Jianhua   +4 more
core   +5 more sources

Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection. [PDF]

, 2018
Innate immune cells quickly infiltrate the site of pathogen entry and not only stave off infection but also initiate antigen presentation and promote adaptive immunity.
A Gladiator, A Ray, AC Patera, AD Joshi, AK Furuya, AM Owyang, AV Ivanov, AY Wen, BC Xu, C Zhao, CE Andoniou, CO Simon, CR Crowe, CW Lio, D Burdette, EH Kobayashi, GJ Bancroft, GM DeNicola, H Kato, H Kawasaki, HS Zhang, HY Cho, J Bystrom, J Lee, JL Bowen, JM Lee, K Tabeta, KA Daniels, KJ Livak, KL Hokeness, KL Hokeness, KM Hsu, LR Johnson, M Boeckh, M Wagner, MA Stacey, MC Cheeran, MJ Crane, MJ Kesic, MJ Reddehase, MK Arababadi, N Nagai, NM Reddy, P Balanescu, P Ye, Q Ma, R Guabiraba, R Saddawi-Konefka, R Seelige, R Seelige, RK Thimmulappa, RL Wheat, S Jonjic, S Jordan, S Kohyama, S Mamo, S Schaedler, S Sell, SL Deshmane, SL Gaffen, SP Francis, T O’Sullivan, T Starnes, TP Salazar-Mather, V Ramirez-Carrozzi, VA Rathinam, W Hou, W Hou, X Song, X Wang, Y Iwakura, Y Shinkai, Y Yageta, Y Zhang, YL Cheng, Z Huang   +75 more
core   +3 more sources

EVA1C Is a Potential Prognostic Biomarker and Correlated With Immune Infiltration Levels in WHO Grade II/III Glioma

Frontiers in Immunology, 2021
BackgroundImmunotherapy is an effective therapeutic approach for multiple human cancer types. However, the correlations between EVA1C and patients’ prognosis as well as immune infiltration remain obscure.
Zhicheng Hu, Shanqiang Qu
doaj   +1 more source

A novel anoikis-related prognostic signature associated with prognosis and immune infiltration landscape in clear cell renal cell carcinoma

Frontiers in Genetics, 2022
Background: Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cell carcinoma (RCC). Anoikis plays an essential function in tumourigenesis, whereas the role of anoikis in ccRCC remains unclear.
Zhuo Chen, Xiao Liu, Zhengjie Zhu, Jin-chao Chen, Chen Wang, Xi Chen, Shao-xing Zhu, Aiqin Zhang   +7 more
semanticscholar   +1 more source

Immune DNA signature of T-cell infiltration in breast tumor exomes. [PDF]

, 2016
Tumor infiltrating lymphocytes (TILs) have been associated with favorable prognosis in multiple tumor types. The Cancer Genome Atlas (TCGA) represents the largest collection of cancer molecular data, but lacks detailed information about the immune ...
Armisen, Ricardo, Carter, Hannah, Dow, Michelle, Gárate Calderón, Valentina, Harismendy, Olivier, Levy, Eric, Marty, Rachel, Woo, Brian   +7 more
core   +2 more sources

Comprehensive Pan-Cancer Genomic Analysis Reveals PHF19 as a Carcinogenic Indicator Related to Immune Infiltration and Prognosis of Hepatocellular Carcinoma

Frontiers in Immunology, 2022
Background As a crucial constituent part of Polycomb repressive complex 2, PHD finger protein 19 (PHF19) plays a pivotal role in epigenetic regulation, and acts as a critical regulator of multiple pathophysiological processes. However, the exact roles of
Zheng Zhu, N. Tang, Ming-Fu Wang, Jing-chao Zhou, Jinglin Wang, Haozhen Ren, Xiao-lei Shi   +6 more
semanticscholar   +1 more source

Pan-Cancer and Single-Cell Analysis Reveals CENPL as a Cancer Prognosis and Immune Infiltration-Related Biomarker

Frontiers in Immunology, 2022
Background Centromere protein L (CENPL) is an important member of the centromere protein (CENP) family. However, the correlation between CENPL expression and cancer development and immune infiltration has rarely been studied. Here, we studied the role of
Ziyang Feng, Yu Chen, Changjing Cai, Jun Tan, Ping Liu, Yihong Chen, Hong Shen, S. Zeng, Ying Han   +8 more
semanticscholar   +1 more source

Distribution of Tumor-Infiltrating Immune Cells in Glioblastoma [PDF]

CNS Oncology, 2018
Evaluation of features related to infiltrating immune cell level in glioblastoma.Tumor-infiltrating lymphocytes (TILs) through H&E staining, and TILs (CD3, CD4, CD8 and CD20) and macrophage (CD68 and CD163) levels through immunohistochemistry were evaluated through digital analysis.CD68 (9.1%), CD163 (2.2%), CD3 (1.6%) and CD8 (1.6%) had the highest ...
Sandro Casavilca, Luis Ojeda, Carlos A. Castaneda, Luis A. Bernabe, Wei Meng, Miluska Castillo, Pamela García-Corrochano, Maria R. Villa-Robles, Enrique Orrego, Rocio Zevallos, Omar Mejia, Carolina Belmar-Lopez, Arnab Chakravarti, Pedro Deza   +13 more
openaire   +3 more sources