Results 51 to 60 of about 662,585 (256)

Distribution of Tumor-Infiltrating Immune Cells in Glioblastoma [PDF]

CNS Oncology, 2018
Evaluation of features related to infiltrating immune cell level in glioblastoma.Tumor-infiltrating lymphocytes (TILs) through H&E staining, and TILs (CD3, CD4, CD8 and CD20) and macrophage (CD68 and CD163) levels through immunohistochemistry were evaluated through digital analysis.CD68 (9.1%), CD163 (2.2%), CD3 (1.6%) and CD8 (1.6%) had the highest ...
Enrique Orrego, Carlos A Castaneda, Miluska Castillo, Luis A Bernabe, Sandro Casavilca, Arnab Chakravarti, Wei Meng, Pamela Garcia-Corrochano, Maria R Villa-Robles, Rocio Zevallos, Omar Mejia, Pedro Deza, Carolina Belmar-Lopez, Luis Ojeda   +13 more
openaire   +3 more sources

Identification of testicular cancer immune infiltrates and novel immune cell subtypes

FEBS Open Bio, 2023
Testicular germ cell tumors (TGCT) are the most common type of testicular cancer, comprising 90–95% of cases and representing the most prevalent solid malignancy in young adult men. Immune infiltrates play important regulatory roles in tumors, but their role in TGCT remains unclear.
Zhiguo Zhu, Xujun Xuan, Xinkun Wang, Miaomiao Wang, Chunyang Meng, Zhonghai Li   +5 more
openaire   +3 more sources

Profiling Tumor Infiltrating Immune Cells with CIBERSORT [PDF]

, 2018
Tumor infiltrating leukocytes (TILs) are an integral component of the tumor microenvironment and have been found to correlate with prognosis and response to therapy. Methods to enumerate immune subsets such as immunohistochemistry or flow cytometry suffer from limitations in phenotypic markers and can be challenging to practically implement and ...
Binbin, Chen, Michael S, Khodadoust, Chih Long, Liu, Aaron M, Newman, Ash A, Alizadeh   +4 more
openaire   +2 more sources

Immune microenvironment infiltration landscape and immune-related subtypes in prostate cancer

Frontiers in Immunology, 2023
BackgroundThe tumor microenvironment (TME) primarily comprises cancer cells, cancer-infiltrating immune cells, and stromal cells. The tumor cells alter the TME by secreting signaling molecules to induce immune tolerance. The immune cell infiltrating the TME influences the prognosis of patients with cancers.
Wei Wu, Xin’an Wang, Wei Le, Chang Lu, Haopeng Li, Yaru Zhu, Xi Chen, Wenbin An, Chengdang Xu, Qiang Wu, Licheng Wang   +10 more
openaire   +3 more sources

Cdx2 regulates immune cell infiltration in the intestine [PDF]

Scientific Reports, 2021
AbstractThe intestinal epithelium is a unique tissue, serving both as a barrier against pathogens and to conduct the end digestion and adsorption of nutrients. As regards the former, the intestinal epithelium contains a diverse repertoire of immune cells, including a variety of resident lymphocytes, macrophages and dendritic cells.
Simon Chewchuk, Sanzida Jahan, David Lohnes   +2 more
openaire   +3 more sources

Characterization of Immune Infiltration and Construction of a Prediction Model for Overall Survival in Melanoma Patients

Frontiers in Oncology, 2021
Reports indicate that the use of anti-programmed cell death-1 (PD-1) and death ligand-1 (PD-L1) monoclonal antibodies for the treatment of patients diagnosed with melanoma has demonstrated promising efficacy.
Gang Li, Xuran Zhu, Chao Liu
doaj   +1 more source

Claudin-low bladder tumors are immune infiltrated and actively immune suppressed [PDF]

JCI Insight, 2016
We report the discovery of a claudin-low molecular subtype of high-grade bladder cancer that shares characteristics with the homonymous subtype of breast cancer. Claudin-low bladder tumors were enriched for multiple genetic features including increased rates of RB1, EP300, and NCOR1 mutations; increased frequency of EGFR amplification; decreased rates ...
Jordan, Kardos, Shengjie, Chai, Lisle E, Mose, Sara R, Selitsky, Bhavani, Krishnan, Ryoichi, Saito, Michael D, Iglesia, Matthew I, Milowsky, Joel S, Parker, William Y, Kim, Benjamin G, Vincent   +10 more
openaire   +2 more sources

TIMER2.0 for analysis of tumor-infiltrating immune cells [PDF]

Nucleic Acids Research, 2020
Abstract Tumor progression and the efficacy of immunotherapy are strongly influenced by the composition and abundance of immune cells in the tumor microenvironment. Due to the limitations of direct measurement methods, computational algorithms are often used to infer immune cell composition from bulk tumor transcriptome profiles.
X Shirley Liu, Bo Li, Qianming Chen, Jing Li, David Cohen, Zexian Zeng, Jingxin Fu, Taiwen Li   +7 more
openaire   +2 more sources

The Heterogeneity of Immune Cell Infiltration Landscape and Its Immunotherapeutic Implications in Hepatocellular Carcinoma

Frontiers in Immunology, 2022
Immunotherapy, closely associated with immune infiltration and tumor mutation burden (TMB), is emerging as a promising strategy for treating tumors, but its low response rate in hepatocellular carcinoma (HCC) remains a major challenge. Herein, we applied
Yuanyuan Guo, Yuanyuan Guo, Jing Yang, Jing Yang, Kaidi Ren, Kaidi Ren, Xueke Tian, Xueke Tian, Hua Gao, Xin Tian, Xin Tian, Xiaojian Zhang, Xiaojian Zhang, Quancheng Kan, Quancheng Kan   +14 more
doaj   +1 more source

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia, Consoli, Francesca, Monti, Matilde, Vermi, William, Vescovi, Raffaella   +4 more
core   +2 more sources