Results 71 to 80 of about 2,585,977 (417)

New insights from integrated bioinformatics analysis: the role of circadian rhythm disruption and immune infiltration in obstructive sleep apnea disease

Frontiers in Immunology, 2023
BackgroundCircadian rhythm disruption and immune infiltration are both closely associated with the development of Obstructive sleep apnea (OSA) disease and a variety of cardiovascular and neurological complications, but their interactions with OSA ...
Xinyue Zhang, Yixuan Wang, Zhou Pan, Ke Hu   +3 more
doaj   +1 more source

Comprehensive analysis of anoikis-related long non-coding RNA immune infiltration in patients with bladder cancer and immunotherapy

Frontiers in Immunology, 2022
Background Anoikis is a form of programmed cell death or programmed cell death(PCD) for short. Studies suggest that anoikis involves in the decisive steps of tumor progression and cancer cell metastasis and spread, but what part it plays in bladder ...
Yao Zhang, Xiaowei Li, Xiaodong Li, Tingting Zhou, Chao Chen, Jiwen Liu, Li Wang, Xin Jiang, Liang Wang, Ming Liu, Youguang Zhao, Sha-dan Li   +11 more
semanticscholar   +1 more source

Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer [PDF]

British Journal of Cancer, 2013
The host immune reaction is represented by immune/inflammatory cell infiltrates. Here we systematically analysed tumour-infiltrating immune/inflammatory cells in pancreatic ductal carcinoma (PDC) and evaluated their clinicopathological impact.Using immunohistochemistry, we examined tumour-infiltrating CD68(+) pan-macrophages, HLA-DR(+)CD68(+) M1 ...
T Kosuge, Rie Yamazaki-Itoh, Yae Kanai, K Shimada, Motoki Iwasaki, Yoshinori Ino, Nobuyoshi Hiraoka   +6 more
openaire   +3 more sources

Characterization of immune infiltration in sarcomatoid hepatocellular carcinoma

Aging, 2021
Sarcomatoid hepatocellular carcinoma (sHCC) is a rare type of liver malignancy. Currently, the tumor immune features of sHCC are poorly understood. We recruited 31 patients with resected sHCC for whom tissue samples and complete clinicopathologic and follow-up data were available.
Chu-Bin Luo, Zheng-Jun Zhou, Qiman Sun, Xiao-Wu Huang, Jia Fan, Tongyi Zhao, Jian Zhou, Zhi-Qiang Hu, Rong-Qi Sun, Hao-Yang Xin, Na Yao, Dan Yin, Shao-Lai Zhou   +12 more
openaire   +3 more sources

Identification of an Immune-Related Prognostic Signature Associated With Immune Infiltration in Melanoma [PDF]

Frontiers in Genetics, 2020
Melanoma is the leading cause of cancer-related death among skin tumors, with an increasing incidence worldwide. Few studies have effectively investigated the significance of an immune-related gene (IRG) signature for melanoma prognosis. Here, we constructed an IRGs prognostic signature using bioinformatics methods and evaluated and validated its ...
Nian Liu, Zijian Liu, Xinxin Liu, Xiaoru Duan, Yuqiong Huang, Zilin Jin, Yi Niu, Liling Zhang, Hongxiang Chen, Hongxiang Chen, Hongxiang Chen   +10 more
openaire   +3 more sources

An individual-based model to explore the impact of psychological stress on immune infiltration into tumour spheroids [PDF]

arXiv, 2023
In recent in vitro experiments on co-culture between breast tumour spheroids and activated immune cells, it was observed that the introduction of the stress hormone cortisol resulted in a decreased immune cell infiltration into the spheroids. Moreover, the presence of cortisol deregulated the normal levels of the pro- and anti-inflammatory cytokines ...
arxiv  

Quantitative Analysis of Immune Infiltrates in Primary Melanoma [PDF]

Cancer Immunology Research, 2018
Abstract Novel methods to analyze the tumor microenvironment (TME) are urgently needed to stratify melanoma patients for adjuvant immunotherapy. Tumor-infiltrating lymphocyte (TIL) analysis, by conventional pathologic methods, is predictive but is insufficiently precise for clinical application. Quantitative multiplex immunofluorescence (
Gartrell, Robyn D., Marks, Douglas K., Hart, Thomas D., Li, Gen, Davari, Danielle R., Wu, Alan, Blake, Zoë, Lu, Yan, Askin. Kayleigh N., Monod, Anthea, Esancy, Camden L., Stack, Edward C., Jia, Dan Tong, Armenta, Paul M., Fu, Yichun, Izaki, Daisuke, Taback, Bret, Rabadan, Raul, Kaufman, Howard L., Drake, Charles G., Horst, Basil, Saenger, Yvonne M.   +21 more
openaire   +4 more sources

TIMER2.0 for analysis of tumor-infiltrating immune cells [PDF]

Nucleic Acids Research, 2020
Abstract Tumor progression and the efficacy of immunotherapy are strongly influenced by the composition and abundance of immune cells in the tumor microenvironment. Due to the limitations of direct measurement methods, computational algorithms are often used to infer immune cell composition from bulk tumor transcriptome profiles.
Zexian Zeng, Taiwen Li, Jing Li, David M. Cohen, Qianming Chen, Jingxin Fu, Jingxin Fu, Bo Li, X. Shirley Liu   +8 more
openaire   +2 more sources

Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes. [PDF]

, 2016
BackgroundMalignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with few treatment options. Tumor immune state has not been characterized in MPNST, and is important in determining response to immune checkpoint blockade.
Bernthal, Nicholas, Chmielowski, Bartosz, Crompton, Joseph G, Dry, Sarah, Eilber, Fritz C, Federman, Noah, Jensen, Sarah, Li, Yunfeng, Nelson, Scott, Shurell, Elizabeth, Singh, Arun S, Tumeh, Paul   +11 more
core   +2 more sources

Generating counterfactual explanations of tumor spatial proteomes to discover effective strategies for enhancing immune infiltration [PDF]

arXiv, 2022
The tumor microenvironment (TME) significantly impacts cancer prognosis due to its immune composition. While therapies for altering the immune composition, including immunotherapies, have shown exciting results for treating hematological cancers, they are less effective for immunologically-cold, solid tumors.
arxiv