Results 81 to 90 of about 2,772,829 (401)
Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes. [PDF]
, 2016 BackgroundMalignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with few treatment options. Tumor immune state has not been characterized in MPNST, and is important in determining response to immune checkpoint blockade.
Bernthal, Nicholas +11 more
core +2 more sources
Frontiers in Immunology, 2022 Tumor mutational burden (TMB) has been reported to determine the response to immunotherapy, thus affecting the patient’s prognosis in many cancers. However, it is unclear whether TMB or TMB-related signature could be used as prognostic indicators for ...
Haoyu Wang +7 more
semanticscholar +1 more source
Immune Characteristics in Biliary Atresia Based on Immune Genes and Immune Cell Infiltration
Frontiers in Pediatrics, 2022 BackgroundBiliary atresia (BA) is a serious biliary disease in infancy. Jaundice is the most visual and prominent symptom, and it mainly involves bile duct cells leading to the loss of intrahepatic and extrahepatic bile ducts. If left untreated, it will eventually progress to liver cirrhosis. The pathogenesis of BA is not clear, and it is now generally
Chenyu Yang +7 more
openaire +3 more sources
Frontiers in Oncology, 2019 Background: Invasive ductal carcinoma (IDC) is a clinically and molecularly distinct disease. Tumor microenvironment (TME) immune phenotypes play crucial roles in predicting clinical outcomes and therapeutic efficacy.Method: In this study, we depict the ...
Xuanwen Bao +7 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundCircadian rhythm disruption and immune infiltration are both closely associated with the development of Obstructive sleep apnea (OSA) disease and a variety of cardiovascular and neurological complications, but their interactions with OSA ...
Xinyue Zhang +3 more
doaj +1 more source
RNA adenosine modifications related to prognosis and immune infiltration in osteosarcoma
Journal of Translational Medicine, 2022 Background RNA adenosine modifications, which are primarily mediated by “writer” enzymes (RMWs), play a key role in epigenetic regulation in various biological processes, including tumorigenesis. However, the expression and prognostic role of these genes
Shijie Chen +21 more
semanticscholar +1 more source
Histopathological image QTL discovery of immune infiltration variants [PDF]
iScience, 2017 AbstractGenotype-to-phenotype association studies typically use macroscopic physiological measurements or molecular readouts as quantitative traits. There are comparatively few suitable quantitative traits available between cell and tissue length scales, a limitation that hinders our ability to identify variants affecting phenotype at many clinically ...
Barry, Joseph D. +5 more
openaire +5 more sources
The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer [PDF]
, 2008 The significance of the inter-relationship between tumour and host local/systemic inflammatory responses in primary operable invasive breast cancer is limited.
A Ciucci +56 more
core +2 more sources
Frontiers in Immunology, 2022 Objectives Cuproptosis is a recently discovered form of programmed cell death; however, its role in ulcerative colitis (UC) remains a void. Methods Three gene expression profiles were acquired from the GEO database.
Jinke Huang +4 more
semanticscholar +1 more source
Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing. [PDF]
, 2019 Neuroinflammation commonly accompanies neurodegeneration, but the specific roles of resident and infiltrating immune cells during degeneration remains controversial.
Burns, Marie E +3 more
core +2 more sources