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The immune memory of innate immune systems

International Immunology
Abstract Immune memory has long been considered a function specific to adaptive immune systems; however, adaptive immune memory alone has not fully explained the mechanism by which vaccines exert their protective effects against nontarget pathogens.
Yasuhiro Kato, Atsushi Kumanogoh
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Adaptation and memory in immune responses

Nature Immunology, 2019
Adaptation is the ability of cells, tissues and organisms to rapidly and reversibly modify their properties to maximize fitness in a changing environment. The activity of immune-system components unfolds in the remarkably heterogeneous milieus to which they are exposed in different tissues, during homeostasis or during various acute or chronic ...
Gioacchino Natoli, Renato Ostuni
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Insect Innate Immune Memory

2018
Recent years have seen a surge in studies on insect immune memory. Here we provide an overview of the current state of evidence for immune memory mechanisms in insects. This group of animals is very heterogeneous, and understanding of the molecular mechanisms behind immune memory remains fragmentary.
Humberto Lanz-Mendoza   +1 more
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A guide to adaptive immune memory

Nature Reviews Immunology
Immune memory - comprising T cells, B cells and plasma cells and their secreted antibodies - is crucial for human survival. It enables the rapid and effective clearance of a pathogen after re-exposure, to minimize damage to the host. When antigen-experienced, memory T cells become activated, they proliferate and produce effector molecules at faster ...
Nora Lam, YoonSeung Lee, Donna L. Farber
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Localized Immune Memory in the Lung

American Review of Respiratory Disease, 1988
Antibody-forming cells (AFC) produced in the lung-associated lymph nodes after lung immunization enter the blood and accumulate mainly in the immunized lung. In lung interstitial tissues and alveoli, AFC mature into plasma cells and produce specific antibody.
D E, Bice, B A, Muggenburg
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Cytomegalovirus memory inflation and immune protection

Medical Microbiology and Immunology, 2019
Cytomegalovirus (CMV) infection induces powerful and sustained T-cell responses against a few selected immunodominant antigenic epitopes. This immune response was named memory inflation, because it does not contract in the long term, and may even expand over months and years of virus latency. It is by now understood that memory inflation does not occur
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Specific memory within innate immune systems

Trends in Immunology, 2005
Research into immune defense has been considerably enriched by the increasing focus on innate immunity. This type of immunity is still considered to lack specific memory, largely because there is no evidence of mechanisms that could provide such memory (such as acquired immunity).
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Parasites and Immune Responses: Memory Illusion?

DNA and Cell Biology, 2003
Immunological memory responses to intracellular protozoa and extracellular helminths govern host resistance and susceptibility to reinfection. Humans and livestock living in parasitic disease endemic regions face continuous exposure from a very early age that often leads to asymptomatic chronic infection over their entire lifespan.
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Malaria and Immune Memory

RESEARCH INVENTION JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES
Malaria remains one of the world’s most devastating infectious diseases, caused by Plasmodium parasites and transmitted through Anopheles mosquitoes. Despite repeated exposure in endemic regions, the development of long-lasting immunity remains elusive due to complex host–parasite interactions, immune evasion mechanisms, and antigenic variation.
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Immune memory downloaded

Nature, 2009
Dennis R. Burton, Pascal Poignard
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