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Innate Immune Memory in Macrophages

Newborn, 2023
Macrophages have been recognized as the primary mediators of innate immunity starting from embryonic/fetal development. Macrophage-mediated defenses may not be as antigen-specific as adaptive immunity, but increasing information suggests that these responses do strengthen with repeated immunological triggers. The concept of innate memory in macrophages
openaire   +2 more sources

Acid ceramidase regulates innate immune memory [PDF]

Cell Reports, 2023
Innate immune memory, also called "trained immunity," is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions. We show that exogenously administered sphingolipids and inhibition of sphingolipid metabolizing enzymes modulate ...
Nils Rother, Cansu Yanginlar, Geoffrey Prévot, Inge Jonkman, Maaike Jacobs, Mandy M.T. van Leent, Julia van Heck, Vasiliki Matzaraki, Anthony Azzun, Judit Morla-Folch, Anna Ranzenigo, William Wang, Roy van der Meel, Zahi A. Fayad, Niels P. Riksen, Luuk B. Hilbrands, Rik G.H. Lindeboom, Joost H.A. Martens, Michiel Vermeulen, Leo A.B. Joosten, Mihai G. Netea, Willem J.M. Mulder, Johan van der Vlag, Abraham J.P. Teunissen, Raphaël Duivenvoorden   +24 more
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Ebola Virus Disease Survivors Show More Efficient Antibody Immunity than Vaccinees Despite Similar Levels of Circulating Immunoglobulins

Viruses, 2020
The last seven years have seen the greatest surge of Ebola virus disease (EVD) cases in equatorial Africa, including the 2013–2016 epidemic in West Africa and the recent epidemics in the Democratic Republic of Congo (DRC).
Till Koch, Monika Rottstegge, Paula Ruibal, Sergio Gomez-Medina, Emily V. Nelson, Beatriz Escudero-Pérez, Matthias Pillny, My Linh Ly, Fara Raymond Koundouno, Joseph Akoi Bore, N’Faly Magassouba, Christine Dahlke, Stephan Günther, Miles W. Carroll, Marylyn M. Addo, César Muñoz-Fontela   +15 more
doaj   +1 more source

Sepsis Induces a Long-Lasting State of Trained Immunity in Bone Marrow Monocytes

Frontiers in Immunology, 2018
Innate immune memory describes the functional reprogramming of innate immune cells after pathogen contact, leading to either a boosted (trained immunity) or a diminished (immune tolerance) response to a secondary stimulus.
Katharina Bomans, Judith Schenz, Isabella Sztwiertnia, Dominik Schaack, Markus Alexander Weigand, Florian Uhle   +5 more
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A Simple Model of Epidemics with Pathogen Mutation [PDF]

, 2001
We study how the interplay between the memory immune response and pathogen mutation affects epidemic dynamics in two related models. The first explicitly models pathogen mutation and individual memory immune responses, with contacted individuals becoming
D.A. Buonagurio, Duncan S. Callaway, H.W. Hethcote, I.M. Longini, J. Lin, J.M. Greenberg, M. E. J. Newman, Michelle Girvan, P. Quenel, S. Gupta, Steven H. Strogatz   +10 more
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Drift and shape—new insights into human immunity against influenza virus neuraminidase

mBio, 2023
Influenza virus hemagglutinin mediates infection by binding sialic acids, whereas neuraminidase cleaves sialic acids to release progeny virions. Both are targets of protective antibodies, but influenza vaccine strain selection and antigen dose are based ...
Annette Fox
doaj   +1 more source

Potential role of gut microbiota in induction and regulation of innate immune memory [PDF]

, 2019
The gut microbiota significantly regulates the development and function of the innate and adaptive immune system. The attribute of immunological memory has long been linked only with adaptive immunity.
Agrewala, Javed N, Das, Deepjyoti Kumar, Nadeem, Sajid, Negi, Shikha, Pahari, Susanta   +4 more
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Innate immune memory in mammals

Seminars in Immunology, 2016
Innate and adaptive immunity have evolved as sophisticated mechanisms of host defence against invading pathogens. Classically the properties attributed to innate immunity are its rapid pleiotropic response, and to adaptive immunity its specificity and ability to retain a long-term memory of past infections.
Hamon, Melanie, Quintin, Jessica
openaire   +3 more sources

Enhancing anti-tumor efficacy and immune memory by combining 3p-GPC-3 siRNA treatment with PD-1 blockade in hepatocellular carcinoma

OncoImmunology, 2022
Hepatocellular carcinoma (HCC) is associated with a high mortality rate and presents a major challenge for human health. Activation of multiple oncogenes has been reported to be strongly associated with the progression of HCC.
Liwei Shao, Xin Yu, Qiuju Han, Xinke Zhang, Nan Lu, Cai Zhang   +5 more
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Immunogenicity and Immune Memory after a Pneumococcal Polysaccharide Vaccine Booster in a High-Risk Population Primed with 10-Valent or 13-Valent Pneumococcal Conjugate Vaccine: A Randomized Controlled Trial in Papua New Guinean Children

Vaccines, 2019
We investigated the immunogenicity, seroprotection rates and persistence of immune memory in young children at high risk of pneumococcal disease in Papua New Guinea (PNG).
Anita H. J. van den Biggelaar, William S. Pomat, Geraldine Masiria, Sandra Wana, Birunu Nivio, Jacinta Francis, Rebecca Ford, Megan Passey, Lea-Ann Kirkham, Peter Jacoby, Deborah Lehmann, Peter Richmond, the 10v13v PCV Trial Team   +12 more
doaj   +1 more source