Results 161 to 170 of about 539,258 (257)

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source

Panmim: a resource of pan-cancer metastasis immune microenvironment. [PDF]

J Transl Med
Zhang X, Hu S, Hu H, Li Y, Nie P, Hu X, Xue R, Xiang X, Zheng L.   +8 more
europepmc   +1 more source

A Novel Microfluidic System for 3D Epidermis and Full‐Thickness Skin Growth for Nanoparticle Safety Assessment

Advanced Healthcare Materials, EarlyView.
This work presents a novel, dynamically perfused, configurable microfluidic system for epidermis‐only (E and full‐thickness skin (FT SoC) growth, emulating human skin structure and barrier function. Upon TiO2 nanoparticle exposure, the system reveals compromised barrier integrity, reduced metabolic activity, increased permeability, and chemokine‐driven
Samantha Costa, Ana B. Carneiro, Filipa Lebre, João Meneses, Alar Ainla, Cacilda Moura, Ernesto Alfaro‐Moreno, Ana R. Ribeiro   +7 more
wiley   +1 more source

Formononetin suppresses osteosarcoma by targeting MYO1B and remodeling the tumor immune microenvironment. [PDF]

APL Bioeng
Liu Y, Xiong L, Feng W, Xie T, Liang J, Yang M, Li S, Luo K, Li F, Tang S, Liu S, Huang Q, Liao S, Liu J, Cai Y, Wei Q, Tang H, Tang F.   +17 more
europepmc   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

The progress and perspective of nanomedicine in modulating the tumor immune microenvironment. [PDF]

Acta Pharm Sin B
Lin N, Tan K, Wei Y, Xie S, Liu J, Ma X.
europepmc   +1 more source

Metronidazole‐Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis

Advanced Healthcare Materials, EarlyView.
A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji, Ruichen Zhang, Dongyi Xu, Patrick C. A. van der Wel, Alessia Lasorsa, Guotai Li, Fangze Guo, Qihui Zhou, Patrick van Rijn   +8 more
wiley   +1 more source

Comprehensive Characterization of the Immune Microenvironment of Colorectal and Gastric Signet Ring Cell Cancer. [PDF]

Cells
Zhang J, Collingwood R, Al Diffalha S, Manna DD, Paluri RK, Mejbel HA, Gbolahan O.   +6 more
europepmc   +1 more source

Porous Coatings by Vapor Sublimation and Deposition for Molecular Channeling and Filtration in an Interstitial Fluid Microfiltration Device

Advanced Healthcare Materials, EarlyView.
A vapor‐based porous coating applied within nitinol tubes demonstrated complete suppression of cellular and tissue ingrowth, overcoming a major limitation of implantable interstitial fluid collection devices. Molecular channeling and diffusion are analyzed with probe molecules, showing reliable transport in vitro and in vivo. The coating also achieved >
Yu‐Ming Chang, Chi‐Yu Huang, Yi‐Jia Ke, Yi‐Wei Lin, Yen‐Hui Chan, Ying‐Chang Lu, Yu‐Chih Chiang, Chen‐Chi Wu, Hsien‐Yeh Chen   +8 more
wiley   +1 more source