Results 21 to 30 of about 128,938 (315)

Effect of HIV infection and antiretroviral therapy on hepatitis B virus (HBV)-specific T cell responses in patients who have resolved HBV infection [PDF]

, 2005
Coinfection with hepatitis B virus (HBV) is a common occurrence in human immunodeficiency virus (HIV)–positive patients and an increasing cause of morbidity and mortality.
Bertoletti, A., Copas, A., Dunn, C., Gilson, R.J., Johnstone, R., Lascar, R.M., Lopes, A.R., Maini, M.K., Reignat, S., Webster, G.   +9 more
core   +1 more source

Immune Reconstitution Kinetics as an Early Predictor for Mortality using Various Hematopoietic Stem Cell Sources in Children [PDF]

, 2013
The severity of complications of allogeneic hematopoietic stem cell transplantation (HSCT) is governed mainly by the status of immune reconstitution. In this study, we investigated differences in immune reconstitution with different cell sources and the ...
Bartelink, Imke Heleen, Belitser, Svetlana V., Boelens, Jaap Jan, Danhof, Meindert, de Pagter, Anne J., Egberts, Toine C.G., Knibbe, Catherijne A.J.   +6 more
core   +1 more source

Synchrotron radiation microtomography of brain hemisphere and spinal cord of a mouse model of multiple sclerosis revealed a correlation between capillary dilation and clinical score [PDF]

J. Comp. Neurol. (2019), 2018
Multiple sclerosis is a neurological disorder in which the myelin sheaths of axons are damaged by the immune response. We report here a three-dimensional structural analysis of brain and spinal cord tissues of a mouse model of multiple sclerosis, known as experimental autoimmune encephalomyelitis (EAE).
arxiv   +1 more source

Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant

Journal of Hematology & Oncology, 2022
Despite the increased usage of post-transplant cyclophosphamide (PTCy) in allogeneic hematopoietic stem cell transplantation (allo-HSCT), our knowledge of immune reconstitution post-allo-HSCT in the setting of PTCy is limited.
Chenchen Zhao, Matthew Bartock, Bei Jia, Neal Shah, David F. Claxton, Baldeep Wirk, Kevin L. Rakszawski, Myles S. Nickolich, Seema G. Naik, Witold B. Rybka, W Christopher C. Ehmann, Raymond J. Hohl, Jessica Valentin, Michelle Bernas-Peterson, Emily M. Gerber, Michele Zimmerman, Joseph A. Mierski, Shin Mineishi, Hong Zheng   +18 more
doaj   +1 more source

Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes [PDF]

, 2020
Integrins are transmembrane proteins involved in hemostasis, wound healing, immunity and cancer. In response to intracellular signals and ligand binding, integrins adopt different conformations: the bent (resting) form; the intermediate extended form; and the ligand-occupied active form.
arxiv   +1 more source

TripHLApan: predicting HLA molecules binding peptides based on triple coding matrix and transfer learning [PDF]

arXiv, 2022
Human leukocyte antigen (HLA) is an important molecule family in the field of human immunity, which recognizes foreign threats and triggers immune responses by presenting peptides to T cells. In recent years, the synthesis of tumor vaccines to induce specific immune responses has become the forefront of cancer treatment.
arxiv  

Phase separation transition of reconstituting k-mers in one dimension [PDF]

J. Stat. Mech. (2015) P04004, 2014
We introduce a driven diffusive model involving poly-dispersed hard k-mers on a one dimensional periodic ring and investigate the possibility of phase separation transition in such systems. The dynamics consists of a size dependent directional drive and reconstitution of k-mers.
arxiv   +1 more source

Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology. [PDF]

, 2014
Pharmacokinetic/pharmacodynamic (PKPD) modelling is used to describe and quantify dose-concentration-effect relationships. Within paediatric studies in infectious diseases and immunology these methods are often applied to developing guidance on ...
Abdel-Rahman, Ahsman, Ambrose, Anderson, Anderson, Anderson, Andes, Andes, Assael, Baley, Barclay, Barclay, Barlogis, Bartelink, Bayles, Benjamin, Benson, Berger, Bhandari, Blumer, Bomgaars, Bonate, Botha, Bouazza, Bradley, Buck, Burkhardt, Call, Charles, Charlotte I.S. Barker, Charrier, Chen, Clave, Cohen-Wolkowiez, Cohen-Wolkowiez, Committee, Craig, De Beaudrap, de Groot, de Hoog, de Hoog, de Hoog, de Repentigny, Doby, Doogue, Dowell, Downing, Driscoll, Driscoll, Drusano, Drylewicz, Du, Dudley, Duval, Elter, Englund, Ette, Ette, Ette, Eva Germovsek, Fallen, Fedele, Filler, Fletcher, Foot, Forrest, Frenkel, Friberg, Garcia, Garrido, Giannelli, Giuliano, Glowka, Gonzalez-Peralta, Grimsley, Groll, Groll, Guedj, Hassan, Hennig, Herbrecht, Hintz, Hong, Hope, Hope, Hope, Hope, Hosoya, Huenecke, Iida, Ikawa, Izquierdo, Jacqz-Aigrain, Jensen, Joanna Lewis, Jodi M. Lestner, Joseph F. Standing, Kafetzis, Karlsson, Kaufman, Kearns, Kelley, Kicklighter, Kim, Kimberlin, Kimberlin, Kimberlin, Knoderer, Koehl, Koenig, Kohli, Krakovska, Krishna, Lam, Lankester, Lavielle, Lee, Lee, Lestner, Lewis, Lewis, Lewis, Li, Li, Lodise, Louie, Luck, Lukas, Marques-Minana, McJunkin, Meszner, Mohamed, Moore, Muller, Muller, Neely, Neely, Nielsen, Ogungbenro, Ohata, Olkinuora, Oxford, Padari, Palumbo, Parker, Pascual, Payen, Perelson, Pescovitz, Pescovitz, Piper, Plunkett, Prague, Preston, Pullen, Putter, Rajagopalan, Renard, Rodriguez, Rodriguez-Tudela, Rollo L. Hoare, Rong, Rudd, Sabin, Saez-Llorens, Saez-Llorens, Salinger, Sardemann, Saxen, Schaefer, Schmitt, Schwinger, Seibel, Seidel, Sherwin, Smith, Standing, Starke, Sugaya, Sullender, Surh, Suyagh, Tamma, Tarral, Tasso, Tedeschi, Terragna, Thiebaut, Thiébaut R, Tod, Tod, Touw, Tulkens, van den Anker, van Hasselt, Vandecasteele, Vaudry, Vervelde, Vezina, Walsh, Waxman, Willemze, Wu, Wurthwein, Yoshizawa, Zeng, Zhang, Zhao, Zobell   +208 more
core   +1 more source

Phase coexistence and spatial correlations in reconstituting k-mer models [PDF]

Phys. Rev. E 94, 012121 (2016), 2016
In reconstituting k-mer models, extended objects which occupy several sites on a one dimensional lattice, undergo directed or undirected diffusion, and reconstitute -when in contact- by transferring a single monomer unit from one k-mer to the other; the rates depend on the size of participating k-mers.
arxiv   +1 more source

Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers [PDF]

, 2005
Stem cell transplantation is used widely in the management of a range of diseases of the hemopoietic system. Patients are immunosuppressed profoundly in the early posttransplant period, and reactivation of cytomegalovirus (CMV) remains a significant ...
Assenmacher, Mario, Billingham, Lucinda, Chakraverty, Ronjon, Cobbold, Mark, Craddock, Charles, Crawley, Charles, Goldman, John, Khan, Naeem, Mahendra, Premini, McDonald, Dorothy, Moss, Paul A. H., Olavarria, Eduardo, Osman, Husam, Pourgheysari, Batoul, Steward, Colin, Tauro, Sudhir   +15 more
core   +5 more sources