Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis. [PDF]
, 2011 Tuberculosis remains an important cause of death among patients infected with the human immunodeficiency virus (HIV). Robust data are lacking with regard to the timing for the initiation of antiretroviral therapy (ART) in relation to the start of ...
Anne E. Goldfeld +25 more
core +3 more sources
A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the effects of anti-inflammatory intervention [PDF]
arXiv, 2020 Pyroptosis is an inflammatory mode of cell death that can contribute to the cytokine storm associated with severe cases of coronavirus disease 2019 (COVID-19). The formation of the NLRP3 inflammasome is central to pyroptosis, which may be induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
arxiv
Application of humanized mice in the safety experiments of antibody drugs
Animal Models and Experimental Medicine, EarlyView.The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun +9 more
wiley +1 more source
Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy. [PDF]
, 2013 ObjectivesTo examine the impact of serum-derived bovine immunoglobulin, an oral medical food known to neutralize bacterial antigen and reduce intestinal inflammation, on restoration of mucosal immunity and gastrointestinal function in individuals with ...
Albanese, Anthony +12 more
core +1 more source
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
Characterization of differences in immune responses during bolus and continuous infusion endotoxin challenges using mathematical modeling [PDF]
arXiv, 2023 Endotoxin administration is commonly used to study the inflammatory response, and though traditionally given as a bolus injection, it can be administered as a continuous infusion over multiple hours. Several studies hypothesize that the latter better represents the prolonged and pronounced inflammation observed in conditions like sepsis.
arxiv
Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome
Movement Disorders, EarlyView.Abstract Background Restless legs syndrome (RLS) is a common sensory‐motor disorder characterized by an urge to move the legs, often with unpleasant sensations, particularly during rest. Current treatments include iron supplementation, dopamine agonists, and opioids, but new therapeutic approaches are needed.
Maria P. Mogavero +8 more
wiley +1 more source
Multiphasic and multifocal cryptococcal immune reconstitution inflammatory syndrome in an HIV-infected patient: interplay of infection and immunity [PDF]
, 2013 SummaryWe report a case of cryptococcal immune reconstitution inflammatory syndrome affecting the lungs, and 10 months later the cervical lymph nodes, in the absence of cryptococcal meningitis, in advanced HIV infection. Our report demonstrates the organ-
Arastéh, Keikawus +6 more
core +1 more source
Molecular Nutrition &Food Research, EarlyView.Pomegranate extracts contain polyphenols with: anti‐angiogenic properties inhibiting angiogenesis in Cancer resulting in decreased cancer growth; pro‐angiogenic properties promoting angiogenesis in chronic wound healing hence increasing the healing process ABSTRACT Angiogenesis plays a critical role in both tumor progression and wound healing.
Anna Eleonora Caprifico +8 more
wiley +1 more source
Immune reconstitution inflammatory syndrome in children [PDF]
, 2010 Paradoxical deterioration due to immune reconstitution inflammatory syndrome (IRIS) occurs in up to 21% of children initiating antiretroviral therapy.
Cotton, M, Meyers, T, Rabie, H
core +1 more source