Results 41 to 50 of about 106,980 (248)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires

Frontiers in Immunology, 2018
The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in ...
Enkelejda Miho, Enkelejda Miho, Alexander Yermanos, Cédric R. Weber, Christoph T. Berger, Christoph T. Berger, Sai T. Reddy, Victor Greiff, Victor Greiff   +8 more
doaj   +1 more source

Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

Nature Communications, 2020
Information on immune receptor repertoire provides important insights on disease progression and therapy development, but can be expensive and time-consuming to obtain.
Igor Mandric, Jeremy Rotman, Harry Taegyun Yang, Nicolas Strauli, Dennis J. Montoya, William Van Der Wey, Jiem R. Ronas, Benjamin Statz, Douglas Yao, Velislava Petrova, Alex Zelikovsky, Roberto Spreafico, Sagiv Shifman, Noah Zaitlen, Maura Rossetti, K. Mark Ansel, Eleazar Eskin, Serghei Mangul   +17 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis

Scientific Reports
While cellular metabolism was proposed to be a driving factor of the activation and differentiation of B cells and the function of the resulting antibody-secreting cells (ASCs), the study of correlations between cellular metabolism and functionalities ...
Olivia T. M. Bucheli, Daniela Rodrigues, Kevin Portmann, Aline Linder, Marina Thoma, Cornelia Halin, Klaus Eyer   +6 more
doaj   +1 more source

Monitoring pharmacologically induced immunosuppression by immune repertoire sequencing to detect acute allograft rejection in heart transplant patients: a proof-of-concept diagnostic accuracy study. [PDF]

PLoS Medicine, 2015
It remains difficult to predict and to measure the efficacy of pharmacological immunosuppression. We hypothesized that measuring the B-cell repertoire would enable assessment of the overall level of immunosuppression after heart transplantation.In this ...
Christopher Vollmers, Iwijn De Vlaminck, Hannah A Valantine, Lolita Penland, Helen Luikart, Calvin Strehl, Garrett Cohen, Kiran K Khush, Stephen R Quake   +8 more
doaj   +1 more source

A Nextflow pipeline for T-cell receptor repertoire reconstruction and analysis from RNA sequencing data

ImmunoInformatics, 2022
T-cell receptor (TCR) analysis is relevant for the study of immune system diseases. The expression of TCRs is usually measured with targeted sequencing approaches where TCR genes are selectively amplified.
Teresa Rubio, Maria Chernigovskaya, Susanna Marquez, Cristina Marti, Paula Izquierdo-Altarejos, Amparo Urios, Carmina Montoliu, Vicente Felipo, Ana Conesa, Victor Greiff, Sonia Tarazona   +10 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The influences of microbial colonisation and germ-free status on the chicken TCRβ repertoire

Frontiers in Immunology, 2023
Microbial colonisation is paramount to the normal development of the immune system, particularly at mucosal sites. However, the relationships between the microbiome and the adaptive immune repertoire have mostly been explored in rodents and humans. Here,
Stefan Dascalu, Stefan Dascalu, Stephen G. Preston, Stephen G. Preston, Robert J. Dixon, Patrik G. Flammer, Steven Fiddaman, Amy Boyd, Joshua E. Sealy, Jean-Remy Sadeyen, Bernd Kaspers, Philippe Velge, Munir Iqbal, Michael B. Bonsall, Adrian L. Smith   +14 more
doaj   +1 more source