Results 31 to 40 of about 106,980 (248)

Adaptive Immune Receptor Repertoire (AIRR) Community Guide to Repertoire Analysis

, 2022
AbstractAdaptive immune receptor repertoires (AIRRs) are rich with information that can be mined for insights into the workings of the immune system. Gene usage, CDR3 properties, clonal lineage structure, and sequence diversity are all capable of revealing the dynamic immune response to perturbation by disease, vaccination, or other interventions. Here
Susanna, Marquez, Lmar, Babrak, Victor, Greiff, Kenneth B, Hoehn, William D, Lees, Eline T, Luning Prak, Enkelejda, Miho, Aaron M, Rosenfeld, Chaim A, Schramm, Ulrik, Stervbo   +9 more
openaire   +2 more sources

IgGeneUsage: differential gene usage in immune repertoires

Bioinformatics, 2020
Abstract Summary Decoding the properties of immune repertoires is key to understanding the adaptive immune response to challenges such as viral infection. One important quantitative property is differential usage of Ig genes between biological conditions.
Simo Kitanovski, Daniel Hoffmann
openaire   +3 more sources

A Model of Immune Suppression and Repertoire Evolution [PDF]

, 2003
We present a stochastic cellular automata model that allows us to study both localized and generalized aspects of the immune system (IS). We show how critical values for T Cell Receptor (TCR) affinity and cross-reactivity (ρ) can determine the course of a viral infection.
John Burns 0001, Heather J. Ruskin
openaire   +1 more source

Immune receptor repertoire for influenza haemagglutinin

Bioscience Reports, 1995
An extensive analysis was made of receptor specificity and gene usage in the neutralising antibody (mAb) and Class II-restricted T cell responses to influenza haemagglutinin (HA) following natural infection of MHC (H-2k or H-2d) congenic mice with X31 virus (H3N2 subtype). Despite the diversity of available antigenic sites on the HA1 subunit, there was
D B, Thomas, A, Patera, C M, Graham, C A, Smith   +3 more
openaire   +2 more sources

The impact of cryopreservation on cytokine secretion and polyfunctionality in human PBMCs: a comparative study

Frontiers in Immunology
IntroductionHuman peripheral blood mononuclear cells (hPBMCs) are widely used in fundamental research and clinical applications as studying their responses to in vitro activation is an effective way to uncover functional alterations and disease ...
Aline Linder, Kevin Portmann, Klaus Eyer, Klaus Eyer   +3 more
doaj   +1 more source

T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

Cell Reports, 2019
Summary: Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research ...
Caren Ramien, Erik C. Yusko, Jan Broder Engler, Stefanie Gamradt, Kostas Patas, Nils Schweingruber, Anne Willing, Sina Cathérine Rosenkranz, Anke Diemert, Anja Harrison, Marissa Vignali, Catherine Sanders, Harlan S. Robins, Eva Tolosa, Christoph Heesen, Petra C. Arck, Alexander Scheffold, Kenneth Chan, Ryan O. Emerson, Manuel A. Friese, Stefan M. Gold   +20 more
doaj   +1 more source

Immunization enhances the natural antibody repertoire

EXCLI journal, 2017
The role of immunization in the production of antibodies directed against immunogens is widely appreciated in laboratory animals and in humans. However, the role of immunization in the development of “natural antibodies” has not been investigated. Natural antibodies are those antibodies present without known history of infection or immunization, and ...
Beinart, Dylan, Ren, Daniel, Pi, Cinthia, Poulton, Susan, Holzknecht, Zoie E., Swanson, Chelsea, Parker, William   +6 more
openaire   +3 more sources

Stimulation-induced cytokine polyfunctionality as a dynamic concept

eLife
Cytokine polyfunctionality is a well-established concept in immune cells, especially T cells, and their ability to concurrently produce multiple cytokines has been associated with better immunological disease control and subsequent effectiveness during ...
Kevin Portmann, Aline Linder, Klaus Eyer
doaj   +1 more source

Single-cell analysis of immune repertoires enabled [PDF]

Proceedings of the National Academy of Sciences, 2021
The adaptive arm of the immune system is perhaps unique among complex organ systems in the vast heterogeneity of its constituent cellular components. This feature, though central to its ability to respond to diverse and dynamic antigenic challenges, has complicated high-resolution single-cell analysis, due to the paucity of features by which an ...
openaire   +2 more sources

Immune repertoire fingerprinting by principal component analysis reveals shared features in subject groups with common exposures

BMC Bioinformatics, 2019
Background Advances in next-generation sequencing (NGS) of antibody repertoires have led to an explosion in B cell receptor sequence data from donors with many different disease states.
Alexander M. Sevy, Cinque Soto, Robin G. Bombardi, Jens Meiler, James E. Crowe   +4 more
doaj   +1 more source