Results 11 to 20 of about 106,980 (248)

Development of ferret immune repertoire reference resources and single-cell-based high-throughput profiling assays [PDF]

Journal of Virology
Domestic ferrets (Mustela putorius furo) are important for modeling human respiratory diseases. However, ferret B and T cell receptors have not been completely identified or annotated, limiting immune repertoire studies.
Evan S. Walsh, Kui Yang, Tammy S. Tollison, Sujatha Seenu, Nicole Adams, Guilhem Zeitoun, Ifigeneia Sideri, Geraldine Folch, Hayden N. Brochu, Hsuan Chou, Sofia Kossida, Ian A. York, Xinxia Peng   +12 more
doaj   +2 more sources

A comprehensive immune repertoire signature distinguishes pulmonary infiltration in SARS-CoV-2 Omicron variant infection [PDF]

Frontiers in Immunology
IntroductionThe coronavirus disease 2019 (COVID-19) global pandemic has been the most severe public health emergency since 2019. Currently, the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been the most dominant ...
Xuechuan Li, Hongyi Zhu, Peipei Xu, Jie Zhang, Zhe Wang, Hui He, Fang Shen, Yi Jiang, Lijuan Shen, Jing Xiang, Linhua Yang, Chao Yang, Hao Jiang, Ganglong Gao, Junshuo Jin, Huojian Shen, Yinping Wang, Linshi Wu, Changlin Qian, Dejun Liu, Weiqing Qiu, Qiwei Li, Yuanwen Chen, Fujun Lin, Yun Liu   +24 more
doaj   +2 more sources

Inferring the immune response from repertoire sequencing. [PDF]

PLoS Computational Biology, 2020
High-throughput sequencing of B- and T-cell receptors makes it possible to track immune repertoires across time, in different tissues, and in acute and chronic diseases or in healthy individuals.
Maximilian Puelma Touzel, Aleksandra M Walczak, Thierry Mora   +2 more
doaj   +6 more sources

Comprehensive characterization and database construction of immune repertoire in the largest Chinese glioma cohort [PDF]

iScience
Summary: Immune receptor repertoire is valuable for developing immunotherapeutic interventions, but remains poorly understood across glioma subtypes including IDH wild type, IDH mutation without 1p/19q codeletion (IDHmut-noncodel) and IDH mutation with ...
Lu Wang, Zhiyuan Xu, Wei Zhang, Lin Li, Xiao Liu, Jing Zhang   +5 more
doaj   +2 more sources

High-throughput immune repertoire analysis with IGoR [PDF]

Nature Communications, 2018
B and T cell receptor diversity can be studied by high-throughput immune receptor sequencing. Here, the authors develop a software tool, IGoR, that calculates the likelihoods of potential V(D)J recombination and somatic hypermutation scenarios from raw ...
Quentin Marcou, Thierry Mora, Aleksandra M. Walczak   +2 more
doaj   +3 more sources

Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment

Journal for ImmunoTherapy of Cancer, 2023
Background High-risk human papillomavirus (HPV) is a primary cause of an increasing number of oropharyngeal squamous cell carcinomas (OPSCCs). The viral etiology of these cancers provides the opportunity for antigen-directed therapies that are restricted
Christine McInnis, Lakshmi Srinivasan, Anthony J Coyle, Shilpa Bhatia, Glenn J Hanna, Ann Marie Egloff, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Daniel C Pregibon   +12 more
doaj   +1 more source

Visualising the immune repertoire [PDF]

BMC Systems Biology, 2007
Antibodies play a central role in the adaptive immunedefense of all vertebrates. Thereby, the specific recognitionof antigen structures by antibody molecules determinesthe success of the immune response. Therefore, the reper-toire of antigen binding sites within the immune systemof an individuum, but also, within a population, has beena mean focus of ...
Svetlana Mollova, Ida Retter, Werner Müller   +2 more
openaire   +1 more source

The size of the immune repertoire of bacteria [PDF]

Proceedings of the National Academy of Sciences, 2019
Significance Some bacteria possess an adaptive immune system that maintains a memory of past viral infections in the CRISPR loci of their genomes. This memory is used to mount targeted responses against later threats but is remarkably shallow: it remembers only a few dozen to a few hundred viruses.
Bradde, Serena, Nourmohammad, Armita, Goyal, Sidhartha, Balasubramanian, Vijay   +3 more
openaire   +4 more sources

Single-cell RNA-seq revealing the immune features of donor liver during liver transplantation

Frontiers in Immunology, 2023
Immune cells, including T and B cells, are key factors in the success of liver transplantation. And the repertoire of T cells and B cells plays an essential function in mechanism of the immune response associated with organ transplantation.
Yi Shan, Debin Qi, Lei Zhang, Lixue Wu, Wenfang Li, Hao Liu, Tao Li, Zhiren Fu, Haili Bao, Shaohua Song   +9 more
doaj   +1 more source

Measuring Intratumoral Heterogeneity of Immune Repertoires [PDF]

Frontiers in Oncology, 2020
There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid structures-along with the associated heterogeneity of the tumor neoantigen landscape-but such analyses remain challenging to perform.
Diana Vladimirovna Yuzhakova, Lilia N. Volchkova, Mikhail Valerievich Pogorelyy, Mikhail Valerievich Pogorelyy, Ekaterina O. Serebrovskaya, Ekaterina O. Serebrovskaya, Irina A. Shagina, Irina A. Shagina, Ekaterina A. Bryushkova, Ekaterina A. Bryushkova, Tatiana O. Nakonechnaya, Tatiana O. Nakonechnaya, Tatiana O. Nakonechnaya, Anna V. Izosimova, Daria S. Zavyalova, Maria M. Karabut, Mark Izraelson, Mark Izraelson, Mark Izraelson, Igor V. Samoylenko, Vladimir E. Zagainov, Vladimir E. Zagainov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Elena V. Zagaynova, George Vladimirovich Sharonov, George Vladimirovich Sharonov, George Vladimirovich Sharonov   +30 more
openaire   +3 more sources