Results 21 to 30 of about 106,980 (248)

PIRD: Pan Immune Repertoire Database [PDF]

Bioinformatics, 2018
Abstract Motivation T and B cell receptors (TCRs and BCRs) play a pivotal role in the adaptive immune system by recognizing an enormous variety of external and internal antigens. Understanding these receptors is critical for exploring the process of immunoreaction and exploiting potential ...
Wei Zhang 0178, Longlong Wang, Ke Liu, Xiaofeng Wei, Kai Yang, Wensi Du, Shiyu Wang, Nannan Guo, Chuanchuan Ma, Lihua Luo, Jinghua Wu, Liya Lin, Fan Yang, Fei Gao, Xie Wang, Tao Li 0071, Ruifang Zhang, Nitin K. Saksena, Huanming Yang, Jian Wang 0065, Lin Fang, Yong Hou, Xun Xu, Xiao Liu   +23 more
openaire   +3 more sources

B-cell receptor repertoire sequencing: Deeper digging into the mechanisms and clinical aspects of immune-mediated diseases

iScience, 2022
Summary: B cells play an essential role in adaptive immunity and are intimately correlated with pleiotropic immune-mediated diseases. Each B cell occupies a unique B cell receptor (BCR), and all BCRs throughout our body form “BCR repertoire.” With the ...
Bohao Zheng, Yuqing Yang, Lin Chen, Mengrui Wu, Shengtao Zhou   +4 more
doaj   +1 more source

Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data [PDF]

Nature Immunology, 2017
High-throughput sequencing of B and T cell receptors is routinely being applied in studies of adaptive immunity. The Adaptive Immune Receptor Repertoire (AIRR) Community was formed in 2015 to address issues in AIRR sequencing studies, including the development of reporting standards for the sharing of data sets.
Florian Rubelt, Christian E Busse, Syed Ahmad Chan Bukhari, Jean-Philippe Bürckert, Encarnita Mariotti-Ferrandiz, Lindsay G Cowell, Corey T Watson, Nishanth Marthandan, William J Faison, Uri Hershberg, Uri Laserson, Brian D Corrie, Mark M Davis, Bjoern Peters, Marie-Paule Lefranc, Jamie K Scott, Felix Breden, Eline T Luning Prak, Steven H Kleinstein   +18 more
openaire   +2 more sources

One by One – Insights into Complex Immune Responses through Functional Single-cell Analysis

CHIMIA, 2020
Immune responses are highly dynamic and complex. The successful completion thereof involves and needs many different cells from the immune system, and requires their specific interactions and functions.
Klaus Eyer
doaj   +1 more source

Quantifying selection in immune receptor repertoires [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The immune system defends against pathogens through a diverse population of T cells that display different antigen recognition surface receptor proteins. Receptor diversity is produced by an initial random gene recombination process followed by selection for a desirable range of peptide binding.
Elhanati, Yuval, Murugan, Anand, Callan Jr., Curtis G, Mora, Thierry, Walczak, Aleksandra   +4 more
openaire   +3 more sources

Population dynamics of immune repertoires [PDF]

, 2017
The evolution of the adaptive immune system is characterized by changes in the relative abundances of the B and T-cell clones that make up its repertoires. To fully capture this evolution, we need to describe the complex dynamics of the response to pathogenic and self-antigenic stimulations, as well as the statistics of novel lymphocyte receptors ...
Desponds, Jonathan, Mayer, Andreas, Mora, Thierry, Walczak, Aleksandra M.   +3 more
openaire   +3 more sources

Cnidarian Immunity and the Repertoire of Defense Mechanisms in Anthozoans [PDF]

Biology, 2020
Anthozoa is the most specious class of the phylum Cnidaria that is phylogenetically basal within the Metazoa. It is an interesting group for studying the evolution of mutualisms and immunity, for despite their morphological simplicity, Anthozoans are unexpectedly immunologically complex, with large genomes and gene families similar to those of the ...
Parisi M. G., Parrinello D., Stabili L., Cammarata M.   +3 more
openaire   +5 more sources

ImmunoDataAnalyzer: a bioinformatics pipeline for processing barcoded and UMI tagged immunological NGS data

BMC Bioinformatics, 2022
Background Next-generation sequencing (NGS) is nowadays the most used high-throughput technology for DNA sequencing. Among others NGS enables the in-depth analysis of immune repertoires.
Julia Vetter, Susanne Schaller, Andreas Heinzel, Constantin Aschauer, Roman Reindl-Schwaighofer, Kira Jelencsics, Karin Hu, Rainer Oberbauer, Stephan M. Winkler   +8 more
doaj   +1 more source

T-Cell Receptor Repertoire as a Predictor of Immune-Related Adverse Events in Renal Cell Carcinoma

Current Issues in Molecular Biology, 2023
Immune checkpoint inhibitors (ICIs) are effective in treating renal cell carcinoma (RCC) but can also cause immune-related adverse events (irAEs). The relationship between irAEs and the T-cell receptor (TCR) repertoire in RCC patients treated with ICIs ...
Takuro Kobayashi, Masayoshi Nagata, Yoshihiro Ikehata, Yuki Nagashima, Naoya Nagaya, Yan Lu, Shigeo Horie   +6 more
doaj   +1 more source

Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish

eLife, 2022
Aging individuals exhibit a pervasive decline in adaptive immune function, with important implications for health and lifespan. Previous studies have found a pervasive loss of immune-repertoire diversity in human peripheral blood during aging; however ...
William John Bradshaw, Michael Poeschla, Aleksandra Placzek, Samuel Kean, Dario Riccardo Valenzano   +4 more
doaj   +1 more source