Results 111 to 120 of about 2,330,708 (370)

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Different serological cross-reactivity of Trypanosoma rangeli forms in Trypanosoma cruzi-infected patients sera [PDF]

, 2008
Background American Trypanosomiasis or Chagas disease is caused by Trypanosoma cruzi which currently infects approximately 16 million people in the Americas causing high morbidity and mortality.
de Moraes, Milene H., Egera, Iriane, Girardia, Fabiana P., Grisard, Edmundo C., Guarneria, Alessandra A., Rodriguesa, Juliana B., Steindel, Mario, Tyler, Kevin M.   +7 more
core   +3 more sources

Characteristic features of the SERA multigene family in the malaria parasite

Parasites & Vectors, 2020
Serine repeat antigen (SERA) is conserved among species of the genus Plasmodium. Sera genes form a multigene family and are generally tandemly clustered on a single chromosome. Although all Plasmodium species encode multiple sera genes, the number varies
Nobuko Arisue, Nirianne M. Q. Palacpac, Takahiro Tougan, Toshihiro Horii   +3 more
doaj   +1 more source

Unique determinants associated with hybridoma proteins expressing a cross-reactive idiotype: frequency among individual immune sera.

Journal of Immunology, 1980
It is possible to prepare antisera that recognize individual members of a family of hybridoma proteins in which all members of the family express the cross-reactive idiotype (IdCR) characteristic of the A/J anti-Ars response.
A. Marshak‐Rothstein, J. D. Benedetto, R. L. Kirsch, M. Gefter   +3 more
semanticscholar   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Dengue and Zika virus cross-reactive human monoclonal antibodies protect against Spondweni virus infection and pathogenesis in mice [PDF]

, 2019
Summary: Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti.
Aliota, Ansarah-Sobrinho, Barba-Spaeth, Cerbino-Neto, Cugola, Culshaw, Dejnirattisai, Dejnirattisai, Dowd, Draper, Driggers, Elong Ngono, Falk, Fernandez, Fox, Goncé, Gorman, Govero, Grant, Haddow, Haddow, Halstead, Hasan, Hessell, Jagger, Kokernot, Lanciotti, Lazear, Ma, MacNamara, Mansuy, Mansuy, Mansuy, McDonald, Miner, Morrison, Morrison, Mukherjee, Nguyen, Oliphant, Pal, Pierson, Pierson, Platt, Richner, Rossi, Rouvinski, Sapparapu, Sheehan, Suy, Taraphdar, White, Zhao   +52 more
core   +3 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Evidence for a regulatory idiotypic network in the in vivo response to H-2 antigens. [PDF]

, 1985
Treatment of BALB/c mice with purified pig antiidiotype to 11-4.1 (anti-H-2Kk) monoclonal antibody has been found previously to induce the appearance of idiotype-bearing molecules (Id') in the serum of these mice, in the absence of detectable antigen ...
Bluestone, JA, Rabinowitz, R, Sachs, DH
core  

Screening of Anti HLA Class One Antibodies in the Sera of Pregnant Women and the Variation of Its Titer During Pregnancy

پزشکی بالینی ابن سینا, 2001
Determination of HLA antigens has an extensive application in paternity,    Histocompatibility testing, and disease suseptibility identification. A vast    arrey of different HLA antisera are required for HLA typing. Such antisera can    be obtained from
Minoo Adib, Mina Adib
doaj