Results 81 to 90 of about 299,767 (358)

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]

, 2013
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
A Casadevall, A Cruz, A Glatman-Freedman, AM Cooper, AR Martineau, B Nandi, C Diveu, C Keller, CE Sutton, CG Feng, Christopher M. Sassetti, CJ Thalhofer, CY Hu, D Kitamura, DB Rawool, DJ Cua, DV Jovanovic, E Lockhart, E Marino, E Roy, E Torrado, EB Eruslanov, FE Lund, FL Ribeiro-Gomes, J Hinchey, J Pedrosa, Jiayong Xu, JL Flynn, JM Daley, Joanne L. Flynn, John Chan, JS Thorson, JU Igietseme, K Dunussi-Joannopoulos, K Hamel, KA Sweeney, Kyri Dunussi-Joannopoulos, L Desvignes, L Li, Lee Kozakiewicz, LJ Brady, M Cella, M Laan, M Zhang, MC Tsai, ML Michel, NK Damle, P Miossec, P Seiler, P Ye, PJ Maglione, PJ Maglione, PJ Maglione, PR Hamann, PS Redford, Qinglin Ou, R Appelberg, R Blomgran, R Gopal, RJ North, SA Fulton, SA Khader, ST Passos, Steven A. Porcelli, T Eddens, T Hamilton, T Korn, T Matsushita, TK Kondratieva, W Ouyang, William R. Jacobs, X Zhang, Y Ito, Yanhua Wang, Yong Chen   +74 more
core   +3 more sources

In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy [PDF]

, 2020
Rationale: Zika virus (ZIKV) is a pathogenic virus known to cause a wide range of congenital abnormalities, including microcephaly, Guillain-Barre syndrome, meningoencephalitis, and other neurological complications, in humans. This study investigated the
Hu, Q, Ke, X, Li, P, Liu, Y, Luo, D, Miao, Y, Sun, J, Tan, Z, Wang, H, Wang, T, Xu, F, Zhang, Y, Zheng, Z   +12 more
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Heterologous Immune Responses of Serum IgG and Secretory IgA Against the Spike Protein of Endemic Coronaviruses During Severe COVID-19

Frontiers in Immunology, 2022
Defining immune correlates of disease severity is important to better understand the immunopathogenesis in COVID-19. Here we made use of a protein microarray platform to detect IgG- and IgA-reactive antibodies in sera and saliva respectively, and assess ...
Wouter L. Smit, Wouter L. Smit, Sophie van Tol, Sanne van der Wal, Femke van Vulpen, Shannon la Grouw, Lenneke van Lelyveld, Gijs Limonard, Ailko Bossink, Gert-Jan Godeke, Sandhya Shrestha, Johan Reimerink, Dirk Eggink, Chantal Reusken, Michiel Heron, Steven Thijsen   +15 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Characterization, cloning and immunogenicity of antigens released by transforming cercariae of Schistosoma mansoni [PDF]

, 2000
A schistosome infection is initiated when the parasite penetrates the skin of a susceptible host. Relatively large quantities of protein are released by transforming cercariae compared to later larval stages.
Coulson, P.S., Harrop, R., Jennings, N., Moutford, A.P., Wilson, R.A.   +4 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Evidence for a regulatory idiotypic network in the in vivo response to H-2 antigens. [PDF]

, 1985
Treatment of BALB/c mice with purified pig antiidiotype to 11-4.1 (anti-H-2Kk) monoclonal antibody has been found previously to induce the appearance of idiotype-bearing molecules (Id') in the serum of these mice, in the absence of detectable antigen ...
Bluestone, JA, Rabinowitz, R, Sachs, DH
core  

Long-term study of the impact of methotrexate on serum cytokines and lymphocyte subsets in patients with active rheumatoid arthritis: correlation with pharmacokinetic measures [PDF]

, 2016
Objective To describe changes in immune parameters observed during long-term methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) and explore correlations with simultaneously measured MTX pharmacokinetic (PKC) parameters ...
Hamilton, Robert, Kremer, Joel M., Lawrence, David A., McInnes, Iain B.   +3 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source