Results 61 to 70 of about 792,761 (305)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Molecular mechanisms of Treg-mediated T cell suppression

Frontiers in Immunology, 2012
CD4+CD25highFoxp3+ regulatory T cells (Tregs) can suppress other immune cells and, thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs prevent autoimmune disease and allergies.
Angelika eSchmidt, Nina eOberle, Peter H. Krammer   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Gene network landscape of mouse splenocytes reveals integrin complex as the A151 ODN-responsive hub molecule in the immune transcriptome

Molecular Therapy: Nucleic Acids, 2023
Homeostatic restoration of an inflammatory response requires quenching of the immune system after pathogen threats vanish. A continued assault orchestrated by host defense results in tissue destruction or autoimmunity.
Volkan Yazar, Ismail Cem Yilmaz, Artun Bulbul, Dennis M. Klinman, Ihsan Gursel   +4 more
doaj   +1 more source

Immune Suppression in Auto-Immune Hemolytic Anemia [PDF]

, 1970
The acquired auto-immune hemolytic anemias represent a diversity of disease states in which the most constant immunologic finding is a positive direct anti-human globulin test (van Loghem, 1965; Swisher et al, 1965).
Moon, John H.
core   +1 more source

Immunity and Immune Suppression in Human Ovarian Cancer [PDF]

Immunotherapy, 2011
Clinical outcomes in ovarian cancer are heterogeneous, independent of common features such as stage, response to therapy and grade. This disparity in outcomes warrants further exploration into tumor and host characteristics. One compelling issue is the response of the patient's immune system to her ovarian cancer.
Claudia C, Preston, Ellen L, Goode, Lynn C, Hartmann, Kimberly R, Kalli, Keith L, Knutson   +4 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

T Regulatory Cells and Priming the Suppressive Tumor Microenvironment

Frontiers in Immunology, 2019
Treg play a central role in maintenance of self tolerance and homeostasis through suppression of self-reactive T cell populations. In addition to that role, Treg also survey cancers and suppress anti-tumor immune responses. Thus, understanding the unique
Christina M. Paluskievicz, Xuefang Cao, Reza Abdi, Pan Zheng, Pan Zheng, Yang Liu, Yang Liu, Jonathan S. Bromberg, Jonathan S. Bromberg, Jonathan S. Bromberg   +9 more
doaj   +1 more source

Immunoregulatory Potential of Exosomes Derived from Cancer Stem Cells. [PDF]

, 2020
Head and neck squamous cell carcinomas (HNSCCs) are malignancies that originate in the mucosal lining of the upper aerodigestive tract. Despite advances in therapeutic interventions, survival rates among HNSCC patients have remained static for years ...
Abouyared, Marianne, Anderson, Johnathon D, Archard, Joehleen A, Belafsky, Peter C, Beliveau, Angela, Bewley, Arnaud F, Birkeland, Andrew, Clayton, Shannon M, Farwell, D Gregory, Rao, Shyam, Wagner, Joseph   +10 more
core   +1 more source

Helminths in the hygiene hypothesis:Sooner or later? [PDF]

, 2014
There is increasing recognition that exposures to infectious agents evoke fundamental effects on the development and behaviour of the immune system. Moreover, where infections (especially parasitic infections) have declined, immune responses appear to be
Maizels, R. M., Mcsorley, H. J., Smyth, D. J.   +2 more
core   +4 more sources