Results 61 to 70 of about 2,062,013 (251)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Influence of the fractions isolated from Gentiana algida Pall. on the state of cellular and humoral chains of immune response

Acta Biomedica Scientifica, 2015
The immune modulatory effect of fractions isolated from the aerial part of Gentiana algida Pall. has been established in experiments on the СВА mice in respect of cellular and humoral immune response at immune suppression caused by azathioprine.
Y. R. Budaeva, V. B. Khobrakova
doaj  

TNFAIP6 defines the MSC subpopulation with enhanced immune suppression activities

Stem Cell Research & Therapy, 2022
Background Mesenchymal stromal/stem cells (MSCs) have been intensively investigated in both pre-clinical and clinical studies. However, the therapeutic efficacy varies resulting from the heterogenicity of MSCs.
Lingyun Li, Lei Yang, Xian Chen, Xiangjuan Chen, Lianghui Diao, Yong Zeng, Jianyong Xu   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

T Regulatory Cells and Priming the Suppressive Tumor Microenvironment

Frontiers in Immunology, 2019
Treg play a central role in maintenance of self tolerance and homeostasis through suppression of self-reactive T cell populations. In addition to that role, Treg also survey cancers and suppress anti-tumor immune responses. Thus, understanding the unique
Christina M. Paluskievicz, Xuefang Cao, Reza Abdi, Pan Zheng, Pan Zheng, Yang Liu, Yang Liu, Jonathan S. Bromberg, Jonathan S. Bromberg, Jonathan S. Bromberg   +9 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands

Nature Communications, 2018
The mechanisms by which measles virus infection induces transient immune suppression in humans are poorly understood. Here, Laksono and colleagues characterise the pathogenesis of measles-associated immune suppression in unvaccinated children, and shed ...
Brigitta M. Laksono, Rory D. de Vries, R. Joyce Verburgh, Eline G. Visser, Alwin de Jong, Pieter L. A. Fraaij, Wilhemina L. M. Ruijs, David F. Nieuwenhuijse, Henk-Jan van den Ham, Marion P. G. Koopmans, Menno C. van Zelm, Albert D. M. E. Osterhaus, Rik L. de Swart   +12 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment

Nature Communications, 2017
Regulatory T cells (Tregs) promote immune suppression in the tumour. Here, the authors show that Tregs suppress cytotoxic T lymphocyte (CTL) activity by impairing Ca2+ signalling and that adoptive transfer of CTLs engineered with an optogenetic control ...
Kyun-Do Kim, Seyeon Bae, Tara Capece, Hristina Nedelkovska, Rafael G. de Rubio, Alan V. Smrcka, Chang-Duk Jun, Woojin Jung, Byeonghak Park, Tae-il Kim, Minsoo Kim   +10 more
doaj   +1 more source

Reverting Immune Suppression to Enhance Cancer Immunotherapy

Frontiers in Oncology, 2020
Tumors employ strategies to escape immune control. The principle aim of most cancer immunotherapies is to restore effective immune surveillance. Among the different processes regulating immune escape, tumor microenvironment-associated soluble factors ...
Bella S. Guerrouahen, Cristina Maccalli, Chiara Cugno, Sergio Rutella, Emmanuel T. Akporiaye, Emmanuel T. Akporiaye   +5 more
doaj   +1 more source