Results 51 to 60 of about 2,062,013 (251)

Use of methylnaltrexone to treat immune suppression [PDF]

, 2023
Methods for treating opioid-induced immune suppression with peripheral opioid antagonists are provided. In one embodiment, the method involves administering methylnaltrexone.

core  

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2⁺ Breast Tumor Microenvironment

, 2022
Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2+ Breast Tumor ...
Elizabeth M. Jaffee (14960445), Julie K. Jang (14991383), Emily F. Davis-Marcisak (15129345), Anuj Gupta (4328764), Gaurav Sharma (749390), Luciane T. Kagohara (15129354), Sathish Kumar Ganesan (15109915), Evanthia T. Roussos Torres (15035010), Valerie H. Narumi (15129342), Sofi Castanon (15129333), Vered Stearns (15129348), Emma Bigelow (10799652), Min Yu (120607), Ajay Vaghasia (15099663), Alyza Skaist (6741407), Christine I. Rafie (15129330), Aaron G. Baugh (15129336), Edgar Gonzalez (15129339), Elana J. Fertig (8609136), Dimitrios N. Sidiropoulos (8812874), Roisin M. Connolly (15129351), Sarah J. Wheelan (15099675), Brian J. Christmas (15115141), Daria A. Gaykalova (8569809), Michael Considine (5269832), Srinivasan Yegnasubramanian (27577)   +25 more
core   +3 more sources

Lactate and Lactylation: Dual Regulators of T-Cell-Mediated Tumor Immunity and Immunotherapy

Biomolecules
Lactate and its derivative, lactylation, play pivotal roles in modulating immune responses within the tumor microenvironment (TME), particularly in T-cell-mediated cancer immunotherapy.
Zhi-Nan Hao, Xiao-Ping Tan, Qing Zhang, Jie Li, Ruohan Xia, Zhaowu Ma   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms [PDF]

, 2003
Copyright @ 2003 The Rockefeller University PressCD4+CD25+ regulatory T (TR) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved.
Fiona Powrie, Maloy, Kevin J., Gordon Dougan, Powrie, Fiona, Dougan, Gordon, Laurence Salaun, Cahill, R, Saunders, NJ, Saunders, Nigel J., Nigel J. Saunders, Salaun, L, Powrie, F, Rachel Cahill, Kevin J. Maloy, Salaun, Laurence, Maloy, KJ, Dougan, G, Cahill, Rachel   +17 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

STHs employ both immune protection and immune suppression mechanisms to evade the host’s immune system.

, 2023
The induction of type 2 immune response is thought to be a crucial immune protection mechanism, while the suppression of dendritic cell function and T cell activation are key immune suppression mechanisms.
Stephen Ochaya (228103), Felix Bongomin (5081681), Musa Manga (14014686), Aaron Salzberg (15429227), Chimdi C. Muoghalu (14782157), Sarah Lebu (10094410), Winnie Kibone (12856784)   +6 more
core   +1 more source

Mathematical modeling of immune suppression

, 2005
Administered antibodies can suppress humoral immune response. Though there are two hypotheses explaining the suppression, such as the epitope-masking and Fc-receptor mediated suppression, the epitope-masking hypothesis has garnered more supports.
Lee, Doheon, Na, D
core   +1 more source

Molecular mechanisms of Treg-mediated T cell suppression

Frontiers in Immunology, 2012
CD4+CD25highFoxp3+ regulatory T cells (Tregs) can suppress other immune cells and, thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs prevent autoimmune disease and allergies.
Angelika eSchmidt, Nina eOberle, Peter H. Krammer   +2 more
doaj   +1 more source

Gene network landscape of mouse splenocytes reveals integrin complex as the A151 ODN-responsive hub molecule in the immune transcriptome

Molecular Therapy: Nucleic Acids, 2023
Homeostatic restoration of an inflammatory response requires quenching of the immune system after pathogen threats vanish. A continued assault orchestrated by host defense results in tissue destruction or autoimmunity.
Volkan Yazar, Ismail Cem Yilmaz, Artun Bulbul, Dennis M. Klinman, Ihsan Gursel   +4 more
doaj   +1 more source