Results 161 to 170 of about 119,167 (289)

The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection [PDF]

, 2022
Nadia Anikeeva, Maria Steblyanko, Leticia Kuri-Cervantes, Marcus Buggert, Michael R. Betts, Yuri Sykulev   +5 more
openalex   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse. [PDF]

J Cell Biol, 2022
Wang MS, Huse M.
europepmc   +1 more source

The Rap GTPases coordinate actin and microtubule cytoskeleton reorganization, and promote antigen extraction at the B cell immune synapse

, 2019
Jia Chao Wang
openalex   +1 more source

Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry [PDF]

, 2021
Teresa T. Nguyen, Dong Ho Shin, Sagar Sohoni, Sanjay Singh, Yisel Rivera-Molina, Hong Jiang, Xuejun Fan, Joy Gumin, Frederick F. Lang, Christopher Alvarez‐Breckenridge, Filipa Godoy‐Vitorino, Lijie Zhai, Erik Ladomersky, Kristen L. Lauing, Marta M. Alonso, Derek A. Wainwright, Candelaria Gomez‐Manzano, Juàn Fueyo   +17 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Faculty Opinions recommendation of Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells.

, 2021
Cosima T. Baldari, Anna Onnis
openalex   +2 more sources

Organic Electrochemical Transistors in Tissue‐Interfaced Bioelectronics

Advanced Science, EarlyView.
This article reviews the design, fabrication, and biological application of organic electrochemical transistors (OECTs), emphasizing their potential in tissue‐interfaced bioelectronics. It covers the fundamental principles of OECTs, strategies for enhancing tissue interfacing, and the development of skin‐mounted and implantable systems.
Ruixiang Bai, Zeyu Zhao, Feng Yan
wiley   +1 more source

Antigen mobility regulates the dynamics and precision of antigen capture in the B cell immune synapse. [PDF]

Proc Natl Acad Sci U S A
McArthur HCW, Bajur AT, Iliopoulou M, Spillane KM.   +3 more
europepmc   +2 more sources

365 Artificial intelligence-based dynamic single-cell imaging reveals enhanced migration and immune synapse formation by IDP-023, an allogeneic g-NK cell product [PDF]

Matthew R. Collinson-Pautz, Hannah Wilson, Mohsen Fathi, Lyle W. Babcock, Linh T. Nguyen, Céline Gracia, Austin B. Bigley, Rebecca Berdeaux, Stefanie J Mandl-Cashman   +8 more
openalex   +1 more source