Results 181 to 190 of about 119,167 (289)

Immune Synapse Residency of Orai1 Alters Ca²⁺ Response of T Cells. [PDF]

Int J Mol Sci, 2021
Voros O, Panyi G, Hajdu P.
europepmc   +1 more source

Protease‐Activated Plasmonic Nanosensors for Predictive Ultrasound‐Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy

Advanced Science, EarlyView.
Protease‐activated plasmonic nanosensors are demonstrated to noninvasively monitor antitumor T cell activity in tumors with anatomical information upon adoptive T cell transfer via ultrasound‐guided photoacoustic imaging. These nanosensors are actuated by granzyme B, a protease secreted by activated cytotoxic T cells during tumor cell killing, which ...
Myeongsoo Kim, Seoyoon Song, Ali Zamat, Paul S. Pelkowski, Shivashankar Subramanian, Melissa Cadena, Sydney Fabrega, Meredith Brienen, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +10 more
wiley   +1 more source

Galectin-9 binding to HLA-DR in dendritic cells controls immune synapse formation and T cell proliferation. [PDF]

Proc Natl Acad Sci U S A
Rodgers-Furones A, Brands T, van Gameren G, Florencio-Zabaleta M, Bathini M, Delgado S, Wijfjes Z, Fedorova K, Classens R, Kroese L, Verdoes M, van Mierlo G, Jiménez-Barbero J, Lindeboom RGH, Ardá A, van Spriel AB, Cano LQ.   +16 more
europepmc   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Immune synapse molecules knockout in induced pluripotent stem cells enables broad NK cell resistance in T cell progeny. [PDF]

Regen Ther
Zhang J, Sumide K, Kanie K, Ishikawa A, Yoshida M, Ishii T, Wang B, Kaneko S.   +7 more
europepmc   +1 more source

SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly. [PDF]

J Exp Med, 2023
Onnis A, Andreano E, Cassioli C, Finetti F, Della Bella C, Staufer O, Pantano E, Abbiento V, Marotta G, D'Elios MM, Rappuoli R, Baldari CT.   +11 more
europepmc   +1 more source

Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes

Advanced Science, EarlyView.
Mid‐infrared photothermal microscopy enables label‐free structural, molecular, and functional imaging of protein aggregates in astrocyte cells. The processes of astrocytes differentiated on a nanomaterial interface are characterized by α‐helical signatures combined with enhanced interfacial thermal resistance properties, while the cell soma of non ...
Panagis D. Samolis, Chiara Lazzarini, Rahmetullah Durgun, Barbara Barile, Giorgia Conte, Tamara Posati, Marco Caprini, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander   +9 more
wiley   +1 more source

TIGIT Affects CAR NK-cell Effector Function in the Solid Tumor Microenvironment by Modulating Immune Synapse Strength. [PDF]

Cancer Immunol Res
Navin I, Dysthe M, Menon PS, Baumgartner C, Sauer T, Varadarajan N, Parihar R.   +6 more
europepmc   +1 more source

Folding for the Immune Synapse: CCT Chaperonin and the Cytoskeleton. [PDF]

Front Cell Dev Biol, 2021
Martín-Cófreces NB, Valpuesta JM, Sánchez-Madrid F.   +2 more
europepmc   +1 more source

Live Cell Linear Dichroism Imaging Reveals Extensive Membrane Ruffling within the Docking Structure of Natural Killer Cell Immune Synapses [PDF]

, 2009
Richard K.P. Benninger, Bruno Vanherberghen, Stephen Young, Sabrina B. Taner, Fiona J. Culley, Tim Schnyder, Mark A. A. Neil, Daniel Wüstner, P. M. W. French, Daniel M. Davis, Björn Önfelt   +10 more
openalex   +1 more source