Results 111 to 120 of about 14,479 (218)

PET imaging of colon cancer CD73 expression using cysteine site-specific 89Zr-labeled anti-CD73 antibody

Scientific Reports
CD73 is a cell-surface ectoenzyme that hydrolyzes the conversion of extracellular adenosine monophosphate to adenosine, which in turn can promote resistance to immune checkpoint blockade therapy.
Kyung-Ho Jung, Mina Kim, Hye Jin Jung, Hyun Jung Koo, Jung-Lim Kim, Hyunjong Lee, Kyung-Han Lee   +6 more
doaj   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

89Zr-mAb uptake interpretation requires the use of tissue to plasma ratios corrected for antibody catabolism

EJNMMI Research
Background Typically, tissue uptake, expressed in tissue over plasma ratio (TPR), is reported from a 89Zr-mAb PET study. Nonspecific antibody catabolism and the residualizing property of 89Zr hamper the use of tissue uptake as a measure for target ...
Marc C. Huisman, Johanna E. E. Pouw, Sandeep S. V. Golla, Damien Huglo, Franck Morschhauser, Josée M. Zijlstra, Jessica E. Wijngaarden, Mirte Stavenga, Hylke J. Sebus, Maarten Slebe, Andrea Thiele, Danielle Vugts, Iris H. C. Miedema, Gerben J.C. Zwezerijnen, Idris Bahce, C. Willemien Menke-van der Houven van Oordt, Dhaval K. Shah, Yvonne W. S. Jauw, Ronald Boellaard   +18 more
doaj   +1 more source

Combination Radioimmunotherapy Approaches and Quantification of Immuno-PET [PDF]

, 2016
Jin Su Kim
core   +1 more source

Exploring the microbiota–skin–brain axis: Chicory extract biotransformed into a postbiotic neurocosmetic enhancer of social and sensory experience

International Journal of Cosmetic Science, EarlyView.
Application of CHICORY EXTRACT by a consumer has the ability to evoke positive emotional responses in individuals who come into tactile contact with the treated skin. Abstract Objective Measuring the influence of cosmetic ingredients on the microbiota‐skin‐brain axis is a difficult challenge.
Stefan Hettwer, Emina Besic Gyenge, Loya Schoeffel, Brigit Suter, Barbara Obermayer   +4 more
wiley   +1 more source

Multi‐omics profiling of chronic immune‐mediated skin diseases: SKINERGY protocol and strategic evaluation

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The SKINERGY study will investigate six immune‐mediated inflammatory skin diseases through a nationwide collaboration across all Dutch university medical centres. Involving 720 patients and 120 healthy volunteers, it is aimed at generating a high‐quality dataset to identify biomarkers that enable personalized treatment strategies and improved disease ...
N. G. Koster, J. M. P. A. van den Reek, E. M. G. J. de Jong, S. van Beugen, A. I. M. van Laarhoven, I. Haeck, M. de Bruin‐Weller, M. L. Schuttelaar, B. Horvath, A. Gostyński, A. Knulst, M. H. Vermeer, L. Nguyen, L. Gerbens, P. Spuls, M. A. Middelkamp‐Hup, V. Exadaktylos, T. Niemeyer‐van der Kolk, A. R. Schrader, A. M. Sluijmers, J. Versteeg, B. W. M. Arents, I. van Ee, J. L. A. G. van der Zon, M. de Leeuw, T. de Leeuw, P. van den Broek, C. Berkhof, D. Vellinga, S. Weidinger, S. Dubrac, Y. Li, M. van Steensel, M. Marchetti‐Deschmann, M. Maurer, H. van der Zee, J. Damman, D. J. Hijnen, F. Wijk, M. M. B. Seyger, H. Röckmann, D. M. W. Balak, M. B. A. van Doorn, R. Rissmann, The Next Generation ImmunoDermatology (NGID) consortium, Rob Vreeken, Eva Cuypers, Boudewijn Lelieveldt, Abdoel El Ghalbzouri, Hanna Niehues, Ellen van den Bogaard, Tom Ederveen, Els van der Pool, Nanda Olde, Debra Trampe, Ellen Stijl‐’t Hart, Lisanne Wezendonk, Johan Westerhuis, Huma Shehwana, Joerg Schreiber, Jeremy Bost, Mie Bech Lukassen, Jimmy Bakker, Juliette Simons, Fauve van den Berge, Colin Spence, Elise Beljaards, Anastasiia Myronenko, Mariona Oliver   +68 more
wiley   +1 more source

CD70: An emerging target for integrated cancer diagnosis and therapy

Clinical and Translational Medicine
CD70, which is a ligand belonging to tumour necrosis factors, exhibits aberrant overexpression among multiple hematologic and solid malignancies and has drawn extensive research enthusiasm as a target to treat and diagnose cancers.
Jiatao Hu, Jinxin Li, Bo Yang, Siyi Wang, Yi Bao, Yiren Yang, Kun Qiao, Fei Guo, Xinxin Gan, Linhui Wang   +9 more
doaj   +1 more source

Immuno-PET Detects Antibody-Drug Potency on Coadministration with Statins. [PDF]

J Nucl Med, 2023
Brown EL, Shmuel S, Mandleywala K, Panikar SS, Berry NK, Rao Y, Zidel A, Lewis JS, Pereira PMR.   +8 more
europepmc   +1 more source

p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging [PDF]

, 2009
Lars R. Perk, Maria J. W. D. Vosjan, Gerard W. M. Visser, Marianne Budde, Paul Jurek, Garry E. Kiefer, Guus A. M. S. van Dongen, PJ Carter, GAMS Dongen van, AM Wu, TK Nayak, I Verel, E Dijkers, LR Perk, PKE Borjesson, WB Nagengast, I Verel, I Verel, A Brouwers, LR Perk, J Mendelsohn, AH Schrijvers, SR Rangan, MJ Welters, T Lindmo, CF Meares, LR Perk, HWAM Jong de, AM Loening, A Yokoyama, M Koizumi, S Pochon, WE Meijs, S Liu, FB Gog van, DL Kukis, MC Chakrabarti   +36 more
core   +1 more source

SUBDUE‐3: SUB‐urothelial DUrvalumab‐89zirconium injEction; a phase 0 biodistribution study protocol

BJU International, EarlyView.
Kevin G. Keane, Richard Gauci, Roslyn J. Francis, Andrew M. Scott, Cynthia Hawks, Andrisha‐Jade Inderjeeth, Ian D. Davis, Jayne Lim, Andrew Redfern, Dickon Hayne   +9 more
wiley   +1 more source