Emerging Advances in Nanomedicine for Targeted Cancer Photoimmunotherapy and Photo-Immunometabolic Therapy. [PDF]
Wiley Interdiscip Rev Nanomed NanobiotechnolSchematic representation of nanoparticle‐mediated photothermal therapy (PTT) inducing anti‐tumor immune responses. Nanoparticles are administered to a tumor‐bearing mouse and accumulate at the tumor site. Upon laser irradiation, the nanoparticles generate reactive oxygen species (ROS) within cancer cells, leading to cellular apoptosis.
Chota A +3 more
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Development of radiopharmaceuticals for targeted alpha therapy: Where do we stand?
Frontiers in Medicine, 2022 Targeted alpha therapy is an oncological treatment, where cytotoxic doses of alpha radiation are locally delivered to tumor cells, while the surrounding healthy tissue is minimally affected.
Roger M. Pallares +2 more
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Radiolabeling human peripheral blood stem cells for positron emission tomography (PET) imaging in young rhesus monkeys. [PDF]
, 2013 These studies focused on a new radiolabeling technique with copper ((64)Cu) and zirconium ((89)Zr) for positron emission tomography (PET) imaging using a CD45 antibody.
Cherry, Simon R +3 more
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Targeted Therapy With Immunoconjugates for Multiple Myeloma
Frontiers in Immunology, 2020 The introduction of proteasome inhibitors (PI) and immunomodulatory drugs (IMiD) has markedly increased the survival of multiple myeloma (MM) patients. Also, the unconjugated monoclonal antibodies (mAb) daratumumab (anti-CD38) and elotuzumab (anti-SLAMF7)
Wassilis S. C. Bruins +3 more
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The Therapeutic Potential of Photoimmunotherapy as a Safe, Effective and Non-Toxic Treatment Option for Superficial Triple Negative Breast Cancer. [PDF]
Cancer MedABSTRACT Triple‐negative breast cancer (TNBC) is the most aggressive breast cancer subtype, lacking estrogen (ER), progesterone (PR), and human epidermal growth factor receptor (HER‐2) expression. It disproportionately affects women of African descent and has a poor clinical prognosis attributed to its acute heterogeneity, thereby causing elevated ...
Biteghe FAN +11 more
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Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages. [PDF]
PLoS ONE, 2011 Sialoadhesin is exclusively expressed on specific subpopulations of macrophages. Since sialoadhesin-positive macrophages are involved in inflammatory autoimmune diseases, such as multiple sclerosis, and potentially in the generation of immune responses ...
Peter L Delputte +9 more
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Frontiers in Pharmacology, 2022 Immune checkpoint mechanisms are important molecular cell systems that maintain tolerance toward autoantigens in order to prevent immunity-mediated accidental damage.
Andrea Zanello +4 more
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Management of HER2-Low Metastatic Breast Cancer: A Comprehensive Statement by an Expert Group from the Middle East and Africa Region [PDF]
Middle East Journal of CancerApproximately 50 to 67% of breast cancers (BCs), traditionally categorized as human epidermal growth factor receptor 2 (HER2)-negative, but demonstrating low HER2 expression, are now being defined as a new HER2-low subset or HER2-low category of BC.
Shaheenah Dawood +9 more
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Antibody-Drug Conjugates: Functional Principles and Applications in Oncology and Beyond
Vaccines, 2021 In the era of precision medicine, antibody-based therapeutics are rapidly enriched with emerging advances and new proof-of-concept formats. In this context, antibody-drug conjugates (ADCs) have evolved to merge the high selectivity and specificity of ...
Charalampos Theocharopoulos +4 more
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Synthesis and biodistribution of immunoconjugates of a human IgM and polymeric drug carriers [PDF]
, 1992 The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody directed against an intracellular tumour-associated antigen and either poly (alpha-L-glutamic acid) (PGA) or poly[N5-(2-hydroxyethyl)-L ...
Anderson, James M. +9 more
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