Results 21 to 30 of about 4,990 (167)

Evaluation of immunoconjugates of non-radioactive lutetium- and yttrium-rituximab – a vibrational spectroscopy study

open access: yesMacedonian Journal of Chemistry and Chemical Engineering, 2015
Fourier Transform Infrared (FT-IR) and Raman spectroscopy were used to study the molecular structure of the recombinant monoclonal antibody and anti-CD20-conjugates which are intended to be used as anti-cancer therapeutic agents.
Darinka Gjorgieva Ackova   +5 more
doaj   +1 more source

UCNP-based Photoluminescent Nanomedicines for Targeted Imaging and Theranostics of Cancer

open access: yesMolecules, 2020
Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells.
Evgenii L. Guryev   +13 more
doaj   +1 more source

Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells

open access: yesToxins, 2021
Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well characterized. Many studies highlight their use in cancer therapy, alone or as immunoconjugates, linked to monoclonal antibodies directed against target cancer cells ...
Rossella Rotondo   +7 more
doaj   +1 more source

FHR4‐based immunoconjugates direct complement‐dependent cytotoxicity and phagocytosis towards HER2‐positive cancer cells

open access: yesMolecular Oncology, 2019
Directing selective complement activation towards tumour cells is an attractive strategy to promote their elimination. In the present work, we have generated heteromultimeric immunoconjugates that selectively activate the complement alternative pathway ...
Carole Seguin‐Devaux   +8 more
doaj   +1 more source

Immunotoxins and Other Conjugates Containing Saporin-S6 for Cancer Therapy

open access: yesToxins, 2011
Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death.
Andrea Bolognesi   +3 more
doaj   +1 more source

Design and Simple Assembly of Gold Nanostar Bioconjugates for Surface-Enhanced Raman Spectroscopy Immunoassays

open access: yesNanomaterials, 2019
Immunoassays using Surface-Enhanced Raman Spectroscopy are especially interesting on account not only of their increased sensitivity, but also due to its easy translation to point-of-care formats.
Maria João Oliveira   +8 more
doaj   +1 more source

Advancements in non-small cell lung cancer treatment: from early to advanced stages

open access: yesOncology in Clinical Practice
Over the past years, tremendous progress has been made in the treatment available for non-small cell lung cancer patients (NSCLC), both in the early and advanced stages of the disease.
Adam Płużański, Aleksandra Piórek
doaj   +1 more source

Treatment strategies for cisplatin-ineligible metastatic bladder cancer: Emerging therapies and future perspectives [PDF]

open access: yesInvestigative and Clinical Urology
Recently, the combination of enfortumab vedotin and pembrolizumab has been recommended as the preferred first-line therapy for metastatic or locally advanced urothelial carcinoma owing to its substantial survival benefits.
Kyung Hwan Kim   +5 more
doaj   +1 more source

Progress in immunoconjugate cancer therapeutics [PDF]

open access: yesCancer Cell, 2003
Advances in immunoconjugate technology have revitalized the "magic bullet" concept of immunotherapeutics for the treatment of cancer. The growing availability of "human" antibodies, the increased epitope repertoire due to genomics and proteomics efforts, and advances in the means of identification and production of tumor-specific antibodies have ...
openaire   +2 more sources

Alpha-particle emitting 213Bi-anti-EGFR immunoconjugates eradicate tumor cells independent of oxygenation. [PDF]

open access: yesPLoS ONE, 2013
Hypoxia is a central problem in tumor treatment because hypoxic cells are less sensitive to chemo- and radiotherapy than normoxic cells. Radioresistance of hypoxic tumor cells is due to reduced sensitivity towards low Linear Energy Transfer (LET ...
Christian Wulbrand   +6 more
doaj   +1 more source

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