Herceptin-Geldanamycin Immunoconjugates [PDF]
Cancer Research, 2004 Abstract The efficacy of monoclonal antibodies (mAbs) as single agents in targeted cancer therapy has proven to be limited. Arming mAbs with a potent toxic drug could enhance their activity. Here we report that conjugating geldanamycin (GA) to the anti-HER2 mAb Herceptin improved the activity of Herceptin.
Raya Mandler +4 more
openaire +1 more source
Antibody-drug conjugates in treating older patients suffering from cancer: what is the real value?
Human Vaccines & Immunotherapeutics, 2021 Immunotherapeutic drugs and target therapies have represented an epochal change in treating cancer patients. They represent an attractive option in oncologists’ armamentarium, particularly if we consider the optimal balance between efficacy and toxicity.
Gianluca Perego +3 more
doaj +1 more source
The future of antiviral immunotoxins [PDF]
, 2016 There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral treatments.
Høy Jakobsen, Mette +3 more
core +1 more source
Biological properties of adriamycin bound to biodegradable polymeric carriers [PDF]
, 1993 Three different conjugates having adriamycin (ADR) bound to the side chain carboxyl groups of high-molecular weight poly (¿--glutamic acid) (PGA) either directly or by interpolation of GlyGly and GlyGlyGlyLeu spacers, respectively, were compared with ...
Bhakoo, M. +8 more
core +6 more sources
Electrochemical Immunosensing of ST2: A Checkpoint Target in Cancer Diseases
Biosensors, 2021 A magnetic beads (MB)-involved amperometric immunosensor for the determination of ST2, a member of the IL1 receptor family, is reported in this work.
Rebeca M. Torrente-Rodríguez +8 more
doaj +1 more source
Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation. [PDF]
, 2015 Photochemical internalisation (PCI) is a technique for improving cellular delivery of certain bioactive agents which are prone to sequestration within endolysosomes.
Adigbli +69 more
core +1 more source
Electrochemical Magnetic Immunosensors for the Determination of Ceruloplasmin [PDF]
, 2013 Electrochemical immunosensors for ceruloplasmin (Cp) are reported for the first time. Two configurations involving magnetic beads (MBs) functionalized with Protein A or Streptavidin for immobilization of Cp antibodies were compared, using competitive ...
González Cortés, Araceli +4 more
core +2 more sources
DOTA-functionalized polylysine: a high number of DOTA chelates positively influences the biodistribution of enzymatic conjugated anti-tumor antibody chCE7agl. [PDF]
PLoS ONE, 2013 Site-specific enzymatic reactions with microbial transglutaminase (mTGase) lead to a homogenous species of immunoconjugates with a defined ligand/antibody ratio.
Jürgen Grünberg +6 more
doaj +1 more source
Pharmaceuticals, 2021 Metastatic castration-resistant prostate cancer is today incurable. Conventional imaging methods have limited detection, affecting their ability to give an accurate outcome prognosis, and current therapies for metastatic prostate cancer are insufficient.
Joanna Strand +5 more
doaj +1 more source
Development of a recombinant antibody to target peptides and proteins to sialoadhesin-expressing macrophages [PDF]
, 2013 Background: Sialoadhesin (Sn)-expressing monocytes/macrophages have been associated with several diseases like inflammatory and autoimmune disorders as well as viral infections, and they also appear to play a role in the initiation of an adaptive immune ...
Delputte, Peter +4 more
core +2 more sources