Results 51 to 60 of about 7,735 (207)
The monoclonal antibody nBT062 conjugated to maytansinoids has potent and selective cytotoxicity against CD138 positive multiple myeloma cells _in vitro_ and _in vivo_ [PDF]
, 2008 CD138 (Syndecan1) is highly expressed on multiple myeloma (MM) cells. In this study, we examined the anti-MM effect of murine/human chimeric CD138-specific monoclonal antibody (mAb) nBT062 conjugated with highly cytotoxic maytansinoid derivatives _in ...
Benjamin Dä +20 more
core +1 more source
A Multiepitope‐Based Lateral Flow Assay for Leprosy Antibodies
Analysis &Sensing, EarlyView.An innovative lateral flow assay for leprosy diagnosis is based on gold nanoparticles and synthetic Mycobacterium leprae epitopes conjugated to keyhole limpet hemocyanin protein to enhance antibody detection. This strategy provides a rapid, accurate, and low‐cost approach for resource‐limited settings, enabling the early detection of infection. Leprosy
Cristiane Zocatelli‐Ribeiro +7 more
wiley +1 more source
New Approaches in Immunotherapy of Behçet Disease [PDF]
, 2013 Behçet Disease (BD) is an autoimmune disorder with recurrent ocular, vascular, central nervous system, articular, mucocutaneous, and gastrointestinal manifestations with unclear etiology and pathogenesis.
Behzad Baradaran +3 more
core +1 more source
Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications
Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin +6 more
wiley +1 more source
Immunoconjugates: Lessons from animal models
Annals of Oncology, 1994 Monoclonal antibody-mediated cancer therapy has evolved through a challenging chain of problems and solutions. The very limited therapeutic success obtained with unarmed monoclonal antibodies has increased the interest in different antibody-based targeting strategies, and numerous preclinical and even clinical studies with immunoconjugates have now ...
S, Canevari +2 more
openaire +2 more sources
Impaired FADD/BID signaling mediates cross-resistance to immunotherapy in Multiple Myeloma
Communications Biology, 2023 The treatment landscape in multiple myeloma (MM) is shifting from genotoxic drugs to immunotherapies. Monoclonal antibodies, immunoconjugates, T-cell engaging antibodies and CART cells have been incorporated into routine treatment algorithms, resulting ...
Umair Munawar +30 more
doaj +1 more source
Inter‐Nanoparticle FRET for Biosensing: Photophysics Versus Size
Angewandte Chemie International Edition, Volume 64, Issue 39, September 22, 2025.Förster resonance energy transfer (FRET) systems with luminescent nanoparticles (NPs) as donors and acceptors (inter‐NP FRET) combine unique photophysical properties with large sizes. This review discusses the influence of NP type, architecture, surface chemistry, and optical properties on FRET and the pros and cons of inter‐NP FRET for bioanalytical ...
Eduard Madirov +3 more
wiley +1 more source
Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components
Toxins, 2011 Immunotoxins and antibody-drug conjugates are protein-based drugs combining a target-specific binding domain with a cytotoxic domain. Such compounds are potentially therapeutic against diseases including cancer, and several clinical trials have shown ...
Luigi Cattel, Paola Brusa, Franco Dosio
doaj +1 more source
Site-specific modification of ED-B-targeting antibody using intein-fusion technology
BMC Biotechnology, 2011 Background A promising new approach in cancer therapy is the use of tumor specific antibodies coupled to cytotoxic agents. Currently these immunoconjugates are prepared by rather unspecific coupling chemistries, resulting in heterogeneous products.
Greven Simone +3 more
doaj +1 more source
Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity [PDF]
, 2014 Photodynamic therapy is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with specific light activation of a photosensitizer agent.
Lamberti, María Julia +2 more
core +1 more source