Results 61 to 70 of about 7,735 (207)
The Journal of Pathology, Volume 267, Issue 1, Page 69-78, September 2025.Abstract Chondroitin sulfate proteoglycan 4 (CSPG4) is a promising target for melanoma immunotherapy, but its expression in benign melanocytic lesions and its diagnostic value remain unexplored. This study assessed CSPG4 expression in benign nevi (BN), dysplastic nevi (DN), and superficial spreading melanomas (SSM), comparing it with PRAME ...
Elias A T Koch +8 more
wiley +1 more source
ChemElectroChem, 2022 Alzheimer's disease (AD), the most common neurodegenerative disorder, demands new cost‐effective and easy‐to‐use strategies for its reliable detection, mainly in the preclinical stages.
Alejandro Valverde +12 more
doaj +1 more source
Photochemistry and Photobiology, Volume 101, Issue 5, Page 1211-1231, September/October 2025.Through mRNA sequencing, proteomics, and flow cytometry, we identified potential cell surface targets toward tumor‐targeted, activatable photoimmunotherapy (taPIT) in advanced high‐grade serous ovarian cancers (HGSOCs) with low EGFR expression. The reliance on EGFR overexpression has been a major limitation of taPIT, which this study seeks to address ...
Sudip Timilsina +3 more
wiley +1 more source
Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity 86Y- or 177Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates [PDF]
, 2015 Purpose: GPA33 is a colorectal cancer (CRC) antigen with unique retention properties after huA33-mediated tumor targeting. We tested a pretargeted radioimmunotherapy (PRIT) approach for CRC using a tetravalent bispecific antibody with dual specificity ...
Carrasquillo, Jorge A. +14 more
core +1 more source
Hematological Oncology, Volume 43, Issue 4, July 2025.ABSTRACT Relapsed/refractory multiple myeloma (RRMM) patients with dialysis‐dependent renal impairment face limited therapeutic options due to exclusion from clinical trials, a lack of evidence‐based guidelines, and inferior outcomes. Bispecific antibodies targeting B‐cell maturation antigen (BCMA) have shown promise in RRMM treatment but remain ...
Michèle Hoffmann +7 more
wiley +1 more source
SYNTHESIS OF 25-HYDROXYVITAMIN D3 CONJUGATE WITH KEYHOLE LIMPET HEMOCYANIN AND OBTAINING OF IMMUNE SERA [PDF]
Biotechnologia Acta, 2015 The study was aimed at obtaining polyclonal antibodies that recognize 25-Hydroxyvitamin D3, for their further specifications and applications in immunochemical test systems of 25-Hydroxyvitamin D3, determination in blood serum.
А. O. Mazanova +5 more
doaj +1 more source
Treatment of CD30-Expressing Germ Cell Tumors and Sex Cord Stromal Tumors with Brentuximab Vedotin: Identification and Report of Seven Cases [PDF]
, 2017 BACKGROUND: Cytotoxic therapy for relapsed and refractory germ cell tumors or metastatic sex cord stromal tumors is rarely effective and is often accompanied by high adverse event rates.
Albany, Costantine +5 more
core +1 more source
Deconstructing the Thymic Microenvironment Through Genesis to Senescence
Immunological Reviews, Volume 332, Issue 1, July 2025.ABSTRACT The thymus is essential for adaptive immunity, orchestrating the differentiation of hematopoietic progenitors into various T‐cell lineages. Thymic epithelial cells (TECs) impart this unique function by mediating the major checkpoints in T‐cell differentiation while also imposing stringent tolerance processes required to prevent autoimmunity ...
Michael D'Andrea +2 more
wiley +1 more source
From Desferrioxamine B Umpolung to an Enantiopure Bifunctional Chelator for 89Zr‐immunoPET
Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.Functional group transformations were performed at the pendent amine residue of desferrioxamine B (DFO), the commercial siderophore used in various medical applications, including iron decorporation, antibiotic development, and molecular imaging.
Laurie Zujew +2 more
wiley +1 more source
Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Anna Galstyan +20 more
doaj +2 more sources