Results 61 to 70 of about 4,990 (167)

Selection of an Anti-CD20, Single-Chain Antibody by Phage ELISA on Fixed Cells

BioTechniques, 1999
Cloning the correct genes that code for antibody-variable domains from hybridomas is often complicated by the presence of several immunoglobulin transcripts, some of them arising from a myeloma cell line.
Stefanie Schmidt, Michael Braunagel, Timo Kürschner, Melvyn Little   +3 more
doaj   +1 more source

Spatiotemporal Dynamic Immunomodulation by Infection‐Mimicking Gels Enhances Broad and Durable Protective Immunity Against Heterologous Viruses

Advanced Science, Volume 12, Issue 9, March 6, 2025.
An infection‐mimicking gel (IM‐Gel) is developed that emulates the spatiotemporal immune dynamics of acute viral infections. By enabling sustained lymph node retention of vaccine components, IM‐Gel enhances humoral and cellular immunity, offering cross‐protection against influenza subtypes and SARS‐CoV‐2 variants.
Seung Mo Jin, Ju Hee Cho, Yebin Seong, Wijesinghe Arachchilage Gayan Chathuranga, Yejin Gwak, Young‐Woock Noh, Min‐Ho Lee, Sang‐Seok Oh, Jin‐Ho Choi, Jong‐Soo Lee, Yong Taik Lim   +10 more
wiley   +1 more source

Predicting Drug Targets in Human Cancers

Journal of Clinical Pharmacy and Therapeutics, Volume 2025, Issue 1, 2025.
Introduction A large amount of knowledge has accumulated regarding the pharmacology of most cancer types, including their side effects, and during the last decade, many novel agents have emerged, accompanied by increased costs for healthcare systems. Aim Artificial intelligence (AI) was applied in healthcare services, and the benefit of its use in the ...
David Calderón Guzmán, Norma Osnaya Brizuela, Armando Valenzuela Peraza, Maribel Ortiz Herrera, Diego E. Ortega Garcia, Hugo Juarez Olguin, Gerardo Barragán Mejía, Md Saquib Hasnain   +7 more
wiley   +1 more source

CD74 in kidney disease

Frontiers in Immunology, 2015
CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT/MIF-2).
Lara eValiño-Rivas, Ciro eBaeza-Bermejillo, Laura eGonzalez-Lafuente, Ana eSanz, Alberto eOrtiz, Alberto eOrtiz, Alberto eOrtiz, Maria D Sanchez-Niño   +7 more
doaj   +1 more source

A Reflection on the Evolution of Antibody‐Based Therapies in Oncology: Trastuzumab as an Exemplar—Commentary on Dijkers et al.

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1577-1587, June 2025.
Sarah A. Holstein
wiley   +1 more source

Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy

Nature Communications, 2019
Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was largely unsuccessful due to their inability to cross blood–brain barrier (BBB).
Anna Galstyan, Janet L. Markman, Ekaterina S. Shatalova, Antonella Chiechi, Alan J. Korman, Rameshwar Patil, Dmytro Klymyshyn, Warren G. Tourtellotte, Liron L. Israel, Oliver Braubach, Vladimir A. Ljubimov, Leila A. Mashouf, Arshia Ramesh, Zachary B. Grodzinski, Manuel L. Penichet, Keith L. Black, Eggehard Holler, Tao Sun, Hui Ding, Alexander V. Ljubimov, Julia Y. Ljubimova   +20 more
doaj   +1 more source

Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins

Toxins, 2019
Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells.
Javier Ruiz-de-la-Herrán, Jaime Tomé-Amat, Rodrigo Lázaro-Gorines, José G. Gavilanes, Javier Lacadena   +4 more
doaj   +1 more source

immunoconjugate

Citation: 'immunoconjugate' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13279 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Therapeutic options in peripheral T cell lymphoma

Journal of Hematology & Oncology, 2016
Peripheral T cell lymphoma (PTCL) is a rare and heterogeneous group of non-Hodgkin lymphomas with a very poor prognosis. The standard first-line treatments have resulted in unsatisfactory patient outcomes.
Yaping Zhang, Wei Xu, Hong Liu, Jianyong Li   +3 more
doaj   +1 more source

EGFR Targeted Cetuximab-Valine-Citrulline (vc)-Doxorubicin Immunoconjugates- Loaded Bovine Serum Albumin (BSA) Nanoparticles for Colorectal Tumor Therapy

International Journal of Nanomedicine, 2021
Zixuan Ye,1,* Yue Zhang,1,* Yuanfen Liu,2,* Yanyan Liu,1 Jiasheng Tu,1 Yan Shen1 1Department of Pharmaceutics, State Key Laboratory of Nature Medicines, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Jiangsu Health ...
Ye Z, Zhang Y, Liu Y, Liu Y, Tu J, Shen Y   +5 more
doaj