Results 81 to 90 of about 7,735 (207)

Comparative Efficacy of Ribosome-Inactivating Protein-Containing Immunotoxins in 2D and 3D Models of Sarcoma

Toxins
Sarcomas are very complex and clinically challenging mesenchymal tumors. Although the standard therapeutic approach has improved the 5-year survival rate, many patients experience local relapses and/or distant metastases.
Giulia Calafato, Massimo Bortolotti, Letizia Polito, Andrea Bolognesi   +3 more
doaj   +1 more source

Site‐Specific Modification of Native IgGs with Flexible Drug‐Load

ChemBioChem, Volume 26, Issue 8, April 14, 2025.
ADC generation from native IgG: using short, positively charged peptides like RAK enables the direct modification of IgG at the glutamine Q295 without the need for engineering. Using azide‐ and thiol‐group containing RAK, the generation of ADCs with different drug‐to‐antibody ratios (DARs) is demonstrated and their properties analyzed in‐vitro and in ...
Jöri E. Wehrmüller, Julia C. Frei, Torsten Hechler, Michael Kulke, Andreas Pahl, Martin Béhé, Roger Schibli, Philipp R. Spycher   +7 more
wiley   +1 more source

Immuno-PET of epithelial ovarian cancer: Harnessing the potential of CA125 for non-invasive imaging [PDF]

, 2014
BACKGROUND: Epithelial ovarian cancer (EOC) is characterized by the overexpression of cancer antigen 125 (CA125), a mucinous glycoprotein that serves as a tumor biomarker.
Andrais, Bonnie, Glubrecht, Darryl, Lapi, Suzanne E, Sharma, Sai Kiran, Wang, Monica, Wuest, Frank, Wuest, Melinda   +6 more
core   +2 more sources

INO‐CD22: A multicenter, real‐world study of inotuzumab ozogamicin safety and effectiveness in adult patients with relapsed/refractory acute lymphoblastic leukemia

Cancer, Volume 131, Issue 7, 1 April 2025.
Abstract Background Inotuzumab ozogamicin (IO) has helped to change the treatment paradigm in B‐cell acute lymphoblastic leukemia (B‐ALL) but real‐world data are limited. Methods The INO‐CD22 study is a multicenter retrospective cohort study of adult patients with relapsed/refractory B‐ALL treated with IO in 24 Italian centers from 2014 to 2019, with ...
Cristina Papayannidis, Elisabetta Petracci, Patrizia Zappasodi, Nicola Fracchiolla, Fabio Ciceri, Chiara Sartor, Elisa Roncoroni, Francesco Di Raimondo, Daniele Mattei, Maria Benedetta Giannini, Francesco Lanza, Michele Gottardi, Maria Ilaria Del Principe, Erika Borlenghi, Monica Fumagalli, Daniele Vallisa, Simona Sica, Nicola Di Renzo, Francesco Fabbiano, Elisabetta Todisco, Paolo de Fabritiis, Mario Luppi, Francesco Passamonti, Paolo Corradini, Fara Petruzziello, Fabrizio Pane, Felicetto Ferrara, Greta Mambelli, Roberta Volpi, Federica Frabetti, Chiara Zingaretti, Giovanni Marconi, Giovanni Martinelli   +32 more
wiley   +1 more source

Spatiotemporal Dynamic Immunomodulation by Infection‐Mimicking Gels Enhances Broad and Durable Protective Immunity Against Heterologous Viruses

Advanced Science, Volume 12, Issue 9, March 6, 2025.
An infection‐mimicking gel (IM‐Gel) is developed that emulates the spatiotemporal immune dynamics of acute viral infections. By enabling sustained lymph node retention of vaccine components, IM‐Gel enhances humoral and cellular immunity, offering cross‐protection against influenza subtypes and SARS‐CoV‐2 variants.
Seung Mo Jin, Ju Hee Cho, Yebin Seong, Wijesinghe Arachchilage Gayan Chathuranga, Yejin Gwak, Young‐Woock Noh, Min‐Ho Lee, Sang‐Seok Oh, Jin‐Ho Choi, Jong‐Soo Lee, Yong Taik Lim   +10 more
wiley   +1 more source

Selection of an Anti-CD20, Single-Chain Antibody by Phage ELISA on Fixed Cells

BioTechniques, 1999
Cloning the correct genes that code for antibody-variable domains from hybridomas is often complicated by the presence of several immunoglobulin transcripts, some of them arising from a myeloma cell line.
Stefanie Schmidt, Michael Braunagel, Timo Kürschner, Melvyn Little   +3 more
doaj   +1 more source

Copper-67 as a therapeutic nuclide for radioimmunotherapy [PDF]

, 2018
.: The application of the beta particle-emitting nuclide 67Cu in radioimmunotherapy is reviewed. The production of the nuclide is outlined, and different production modes are discussed with an emphasis on cyclotron production.
Novak-Hofer, Ilse, Schubiger, August
core  

Predicting Drug Targets in Human Cancers

Journal of Clinical Pharmacy and Therapeutics, Volume 2025, Issue 1, 2025.
Introduction A large amount of knowledge has accumulated regarding the pharmacology of most cancer types, including their side effects, and during the last decade, many novel agents have emerged, accompanied by increased costs for healthcare systems. Aim Artificial intelligence (AI) was applied in healthcare services, and the benefit of its use in the ...
David Calderón Guzmán, Norma Osnaya Brizuela, Armando Valenzuela Peraza, Maribel Ortiz Herrera, Diego E. Ortega Garcia, Hugo Juarez Olguin, Gerardo Barragán Mejía, Md Saquib Hasnain   +7 more
wiley   +1 more source

Tumor‐Associated Carbohydrate Antigen 19–9 (CA 19–9), a Promising Target for Antibody‐Based Detection, Diagnosis, and Immunotherapy of Cancer

ChemMedChem, Volume 19, Issue 24, December 16, 2024.
Carbohydrate antigen 19–9 (CA 19–9), also known as sialyl Lewis A, is a tetrasaccharide overexpressed on a wide range of cancerous cells, most prominently pancreatic ductal adenocarcinoma. The review discusses the synthesis of CA 19–9, elicitation of antibodies through vaccination, development of anti‐CA 19–9 monoclonal antibodies, and their ...
Athar Nakisa, Lorenzo F. Sempere, Xi Chen, Linda T. Qu, Daniel Woldring, Howard C. Crawford, Xuefei Huang   +6 more
wiley   +1 more source

Targeted photodynamic therapy : a novel approach to abolition of human cancer stem cells [PDF]

, 2018
: Cancer is a global burden that has prompted extensive research into prevention and treatment, over many decades. Scientific studies have shown that subset of cells within a tumour, known as cancer stem cells (CSCs), are responsible for tumourigenesis ...
Abrahamse, Heidi, Chizenga, Elvin, Crous, Anine, Hodgkinson, Natasha   +3 more
core   +2 more sources