Results 101 to 110 of about 1,577 (196)

Dynamics of Endogenous Intoxication Parameters in Multidrug-Resistant Destructive Pulmonary Tuberculosis

Aktualʹnaâ Infektologiâ, 2014
Tuberculosis belongs to interleukin-dependent immunodeficiency infectious diseases which are accompanied by systemic inflammatory response syndrome with pronounced endogenous intoxication, i.e.
L.D. Todoriko, I.V. Yeremenchuk, S.A. Batranovskaia, V.P. Shapovalov   +3 more
doaj   +1 more source

A phase Ib/II study of modakafusp alfa alone and in combination with pembrolizumab in patients with advanced or metastatic solid tumors

Frontiers in Oncology
BackgroundModakafusp alfa is a novel immunocytokine comprising two attenuated interferon-α2b molecules fused to an anti-CD38 IgG4 monoclonal antibody.
David Gill, Charles L. Cowey, Gregory A. Daniels, David Sommerhalder, Raghad Abdul-Karim, John M. Kirkwood, Joanna Kolodney, Inderjit Mehmi, Rachel Roberts-Thomson, James Strauss, Sajeve Thomas, Eric Whitman, Yan Xing, Meredith McKean, Sabrina Collins, Cheryl Li, Gurpanna Saggu, Tian Chen, Shining Wang, Marina Lewis, Xavier Parot, Melissa Johnson   +21 more
doaj   +1 more source

Anti-CD38-IFNα(att) retains strong on-target tumor cell activity with reduced off-target activity in vitro.

, 2016
Two assays were used to evaluate the antigen specificity of anti-CD38 targeted IFNα’s. The graphs on the left show viability assays of treated ARP-1 MM cells three days after incubation with IFNα compounds.
James Berenson (3111285), Anthony Doyle (577129), Yong Yun (3111264), Haiming Chen (355433), David S. Wilson (36463), Maya Sokolovsky (3111255), Moti Rosenstock (3111276), Eric Sanchez (3111288), Tetsuya Taura (3111270), Steffen Nock (3111279), Collette Behrens (3111261), Angela Sho (3111273), Sarah L. Pogue (3111267), Hussein Hallak (3019602), Mingying Bi (3111258), Glen Mikesell (3111282)   +15 more
core   +1 more source

Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts

, 2012
The selective delivery of bioactive agents to tumors reduces toxicity and enhances the efficacy of anticancer therapies. In this study, we show that the antibody F8, which recognizes perivascular and stromal EDA-fibronectin (EDA-Fn), when conjugated to ...
A. Berndt, M. Moschetta, G. Valbusa, F. Pretto, D. Neri, H. Kosmehl, K. Schwager, R. Giavazzi, P. Oliva, P. Richter, M. R. Bani, M. Kaspar, BASSI, ANDREA, E. Micotti, E. Trachsel, K. Galler   +15 more
core   +1 more source

Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model

, 2015
Background and purposeRecently, we have shown that radiotherapy (RT) combined with the immunocytokine L19-IL2 can induce long-lasting antitumour effects, dependent on ED-B expression and infiltration of cytotoxic T cells.
Evert J. Van Limbergen, Ludwig Dubois, Dario Neri, Rianne Biemans, Senden-Gijsbers, Birgit L.M.G., Losen, Mario, Ala Yaromina, Senden-Gijsbers, Birgit L. M. G., Neri, Dario; id_orcid, Lieuwes, Natasja G., Neri, Dario, Biemans, Rianne, Wilfred T.V. Germeraad, Lambin, Philippe, Mario Losen, Nicolle H. Rekers, Rekers, Nicolle H., Natasja G. Lieuwes, Limbergen, Evert J. van, Catharina M.L. Zegers, Dubois, Ludwig, Philippe Lambin, Van Limbergen, Evert J., Yaromina, Ala, Germeraad, Wilfred T. V., Germeraad, Wilfred T.V., Zegers, Catharina M.L., Zegers, Catharina M. L., Birgit L.M.G. Senden-Gijsbers, Losen M, Senden-Gijsbers BL, Dubois L, Biemans R, Lambin P, Yaromina A, Germeraad WT, Lieuwes NG, Van Limbergen EJ, Neri D, Zegers CM, Rekers NH   +40 more
core   +1 more source

Intralesional administration of L19-IL2/L19-TNF in stage III or stage IVM1a melanoma patients: Results of a phase II study

, 2015
The intratumoral injection of cytokines, in particular IL2, has shown promise for cutaneous melanoma patients with unresectable disease or continuous recurrence despite surgery.
MIRACCO, CLELIA, Maurichi, Andrea, CUTAIA, ORNELLA, Santinami, Mario, Neri, Dario; id_orcid, Maurichi, A, Lazzeri, A, Maio, Michele, Elia, G, Patuzzo, R, Di Giacomo, Am, Gallino, Gianfranco, Patuzzo, Roberto, Giovannoni, Leonardo, Di Florio, Annabella, Elia, Giuliano, Fazio, Claudio, FAZIO, CAROLINA, Di Florio, A, Neri, D, Lazzeri, Andrea, Gallino, G, Giovannoni, L, Santinami, M., Di Giacomo, Anna M., DANIELLI, RICCARDO, Maio, M   +26 more
core   +1 more source

Issue Information

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 1893-1896, December 2025.
wiley   +1 more source

Improving methods for cytokine immunotherapy of cancer

, 2016
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2016.Cataloged from PDF version of thesis.Includes bibliographical references.Cytokine therapy can activate potent antitumor responses, yet collateral toxicity ...
Tzeng, Alice
core  

Development and functional analysis of a cell based potency assay for the immunocytokine L19-IL2

, 2010
Gegenwärtig befinden sich viele biopharmazeutische Präparate wie beispielsweise Immunzytokine in der Forschungs- und Entwicklungspipeline pharmazeutischer Unternehmen. Immunzytokine sind bifunktionale Proteine, die aus einem spezifischen Antikörperanteil
Winter, Jonas P.
core   +1 more source

Preclinical and clinical studies of a tumor targeting IL-12 immunocytokine

Frontiers in Oncology
The clinical success of immune checkpoint inhibitors (ICIs) has demonstrated the promise and challenges of cancer immunotherapy. There is an unmet need to develop novel cancer therapies that can provide clinical benefit for most patients with solid ...
Christine M. Minnar, Grace Lui, James L. Gulley, Jeffrey Schlom, Sofia R. Gameiro   +4 more
doaj   +1 more source