Immunocytokine - Open Access .click

Results 111 to 120 of about 1,577 (196)

L19-IL2 Immunocytokine in Combination with the Anti-Syndecan-1 46F2SIP Antibody Format: A New Targeted Treatment Approach in an Ovarian Carcinoma Model

, 2019
Epithelial ovarian cancer (EOC) is the fifth most common cancer affecting the female population. At present, different targeted treatment approaches may improve currently employed therapies leading either to the delay of tumor recurrence or to disease ...
Gabriella Pietra +7 more
core +1 more source

Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts

, 2015
Anti-angiogenic therapy of solid tumors has until now failed to produce the long lasting clinical benefits desired, possibly due to the complexity of the neoangiogenic process.
ORECCHIA, PAOLA +5 more
core +1 more source

Immunostimulatory activity and antitumor efficacy of mSOT201 immunocytokine

Cytokine-based therapies of malignant diseases are often limited by dose-dependent systemic toxicity and low efficacy. Here, we evaluated mSOT201 immunocytokine consisting of an IL-15 mutein linked through short flexible oligopeptide linker to IL-15Rα ...
Mazhara, Vladyslav
core

Spatial multiomics to inform immunocytokine engineering: knowledge base, gaps, and QC solutions. [PDF]

Front Immunol
Patel P, Batty LD, Bleck M, Nathan S.
europepmc +1 more source

Collagen-Binding IL-15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self-Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity. [PDF]