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[Immunotoxins and immunocytokines].
Medecine sciences : M/S, 2020Cytokines and biological toxins represent two potent classes of biomolecules that have long been explored for their potential as therapeutics. Considerable side effects and poor pharmacokinetics frequently observed with both have limited their broad application.
Alicia, Contet +3 more
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Immunocytokines: amplification of anti-cancer immunity
Cancer Immunology, Immunotherapy, 2003Many cancers elicit an anti-tumor immune response, which is nevertheless unable to protect the patient. One approach to boost anti-tumor immunity is to target immunostimulatory cytokines to the tumor. Such targeting can be achieved by generating chimeric proteins (immunocytokines) in which the cytokine in question is fused to the C-terminus of a tumor ...
Craig B, Davis, Stephen D, Gillies
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Immunocytokines for Cancer Immunotherapy
2004Immunologic approaches to cancer therapy rely on two distinct capabilities of the immune system: targeting the tumor microenvironment by recognizing molecules expressed to a greater extent on tumor cells than normal cells and generating immune responses that can kill tumor cells (1,2).
Paul M. Sondel, Steven D. Gillies
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Immunocytokines and cytokine neutralization for cancer immunotherapy
Trends in CancerDespite deep and growing knowledge of cytokine functions, immunotherapies based on the control of these molecules have minimally impacted cancer patient management because of limited efficacy and narrow therapeutic windows. Opportunities to enhance efficacy and mitigate side effects arise from local delivery and targeting antitumor cytokines to tumor ...
Pedro Berraondo +9 more
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Tripokin:
AbstractAntibodies that target the tumor microenvironment can be used to deliver pro‐inflammatory payloads, such as cytokines. Cytokines are small proteins able to modulate the activity of the immune system, and antibody–cytokine fusion proteins have been tested in preclinical and clinical settings.
Prodi, Eleonora +13 more
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Preclinical and clinical development of immunocytokines.
Current opinion in investigational drugs (London, England : 2000), 2003Advances in preclinical and clinical development have demonstrated that monoclonal antibodies and immuno-activating cytokines have a beneficial role in certain clinical oncology settings. Genetic engineering has now been used to create 'immunocytokines (ICs)'.
Paul M, Sondel +4 more
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Immunocytokines for Cancer Therapy
Forum on Immunopathological Diseases and Therapeutics, 2014Philipp Probst, Dario Neri
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