Neoplasia, 2006 The immunocytokine scFvMEL/TNF, a fusion protein composed of human tumor necrosis factor (TNF) and a single-chain Fv antibody (scFv) scFvMEL targeting the melanoma gp240 antigen, demonstrates impressive cytotoxic effects against human melanoma cell lines
Lawrence H Cheung, Ting Niu, Yuying Liu
exaly +4 more sources
Novel immunocytokine IL12-SS1 (Fv) inhibits mesothelioma tumor growth in nude mice. [PDF]
PLoS ONE, 2013 Mesothelin is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed on the cell surface of malignant mesothelioma. Monoclonal antibodies against mesothelin are being evaluated for the treatment of mesothelioma.
Heungnam Kim, Wei Gao, Mitchell Ho
doaj +2 more sources
Utilizing Immunocytokines for Cancer Therapy [PDF]
Antibodies, 2021 Cytokine therapy for cancer has indicated efficacy in certain diseases but is generally accompanied by severe toxicity. The field of antibody–cytokine fusion proteins (immunocytokines) arose to target these effector molecules to the tumor environment in ...
Erin Runbeck +3 more
doaj +5 more sources
OncoImmunology, 2023 The immunocytokine PD1-IL2v was designed to overcome liabilities and improve efficacy of IL-2 therapies. PD1-IL2v preferentially targets PD-1+ T-cells and acts on antigen-specific stem-like PD-1+ TCF-1+ CD8+ T-cells expanding and differentiating them ...
Laura Codarri Deak +3 more
doaj +2 more sources
IFN-γ and IL-22 in premature ovarian insufficiency correlation with ovarian reserve markers and pathogenic implications: a cross-sectional study [PDF]
BMC Women's HealthBackground This case-control study aimed to investigate serum immunocytokine profiles and their clinical relevance in premature ovarian insufficiency (POI), with a particular focus on the potential of these cytokines as diagnostic biomarkers.
Min He +9 more
doaj +2 more sources
Serum-free production of anti-huCD20(hγ1)-IL2no-alpha immunocytokine: a promising therapeutic for B-NHL [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionMammalian cell cultures are widely used for producing complex biopharmaceuticals that require human-like post-translational modifications, such as antibody-based therapeutics.
Debbie Laura Bergantiños Albernas +12 more
doaj +2 more sources
Antibody landscape of C57BL/6 mice cured of B78 melanoma via a combined radiation and immunocytokine immunotherapy regimen [PDF]
Frontiers in Immunology, 2023 Sera of immune mice that were previously cured of their melanoma through a combined radiation and immunocytokine immunotherapy regimen consisting of 12 Gy of external beam radiation and the intratumoral administration of an immunocytokine (anti-GD2 mAb ...
Anna Hoefges +20 more
doaj +2 more sources
Targeting Attenuated Interferon-α to Myeloma Cells with a CD38 Antibody Induces Potent Tumor Regression with Reduced Off-Target Activity. [PDF]
PLoS ONE, 2016 Interferon-α (IFNα) has been prescribed to effectively treat multiple myeloma (MM) and other malignancies for decades. Its use has waned in recent years, however, due to significant toxicity and a narrow therapeutic index (TI).
Sarah L Pogue +15 more
doaj +2 more sources
NHS-IL12, a Tumor-Targeting Immunocytokine
ImmunoTargets and Therapy, 2021 John W Greiner, Y Maurice Morillon II, Jeffrey Schlom Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USACorrespondence: Jeffrey SchlomLaboratory of Tumor ...
Greiner JW, Morillon II YM, Schlom J
doaj +4 more sources
Target receptor expression dictates the selective intra-tumoral targeting of CD8+ T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients [PDF]
Frontiers in ImmunologyIntroductionImmune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have shown considerable promise as a therapeutic modality in oncology. Despite their ability to target stem-like CD8+ T cells and give rise to exhaustion-fated effector CD8+ T ...
Amrita Manchala +7 more
doaj +2 more sources