Results 31 to 40 of about 1,577 (196)

Soluble Expression of a Neo2/15-Conjugated Single Chain Fv against PD-L1 in Escherichia coli

Current Issues in Molecular Biology, 2022
Immunocytokines, antibody-cytokine fusion proteins, have the potential to improve the therapeutic index of cytokines by delivering the cytokine to the site of localized tumor cells using antibodies.
Sun-Hee Kim, Hee-Jin Jeong
doaj   +1 more source

Administration of fusion cytokines induces tumor regression and systemic antitumor immunity

MedComm, 2021
It is difficult to improve the curative effects of cancer immunotherapy on solid tumors. Cytokines, as powerful immune regulators, show potential in activating host antitumor immunity.
Jinyu Zhang, Xuan Zhao
doaj   +1 more source

Protocol schema for tumor-bearing companion dogs receiving external beam radiation therapy in combination with intratumoral hu14.18-IL2 immunocytokine.

, 2021
Protocol schema for tumor-bearing companion dogs receiving external beam radiation therapy in combination with intratumoral hu14.18-IL2 immunocytokine.
Zachary S. Morris (6287090), Christine Jaskowiak (11268701), Eduardo Aluicio-Sarduy (1610008), Ilene D. Kurzman (11268692), Joseph Grudzinski (11268689), Jonathan W. Engle (325235), Elizabeth A. Oseid (11268698), Michelle M. Turek (11268686), Mark R. Albertini (11268704), David M. Vail (11268710), Paul M. Sondel (5408369), Kara Magee (11268683), Cindy L. Zuleger (11268695), Karla Esbona (3580781), Reinier Hernandez (1329030), Ian R. Marsh (3041166), Bryan Bednarz (11268707), Jamey P. Weichert (400808)   +17 more
core   +1 more source

Antibody-Based Targeting of Interferon-Beta-1a Mutein in HER2-Positive Cancer Enhances Antitumor Effects Through Immune Responses and Direct Cell Killing

Frontiers in Pharmacology, 2021
Type I interferon (IFN) has been approved as an anticancer agent to treat some malignancies. However, IFNs have a short in vivo half-life, systemic toxicity, and poor biophysical properties, which prevent it from being widely used for cancer therapy ...
Chan Gyu Lee, Chan Gyu Lee, TaeEun Kim, Sungyoul Hong, Jongwan Chu, Ju Eun Kang, Hee Geon Park, Jun Young Choi, Kyoung Song, Sun Young Rha, Soohyeon Lee, Joon-Seok Choi, Sun Min Kim, Hae Min Jeong, Young Kee Shin, Young Kee Shin, Young Kee Shin, Young Kee Shin   +17 more
doaj   +1 more source

Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution [PDF]

, 2014
Cytokine therapy can activate potent, sustained antitumor responses, but collateral toxicity often limits dosages. Although antibody–cytokine fusions (immunocytokines) have been designed with the intent to localize cytokine activity, systemic dose ...
Tzeng, Alice, Wittrup, Karl Dane, Opel, Cary Francis, Kwan, Byron Hua, Navaratna, Tejas   +4 more
core   +1 more source

The Immunocytokine FAP-IL-2v Enhances Anti-Neuroblastoma Efficacy of the Anti-GD2 Antibody Dinutuximab Beta [PDF]

, 2022
Treatment of high-risk neuroblastoma (NB) patients with the anti-GD2 antibody (Ab) dinutuximab beta (DB) improves survival by 15%. Ab-dependent cellular cytotoxicity (ADCC) is the major mechanism of action and is primarily mediated by NK cells.
Lode, Holger N., Sascha Troschke-Meurer, Alexander Zikoridse, Maxi Zumpe, Simon Biskupski, Biskupski, Simon, Zumpe, Maxi, Troschke-Meurer, Sascha, Justus Leopold, Siebert, Nikolai, Zikoridse, Alexander, Holger N. Lode, Nikolai Siebert, Leopold, Justus   +13 more
core   +1 more source

Cyclophosphamide augments the efficacy of in situ vaccination in a mouse melanoma model

Frontiers in Oncology, 2023
IntroductionWe have previously shown that an intratumoral (IT) injection of the hu14.18-IL2 immunocytokine (IC), an anti-GD2 antibody linked to interleukin 2, can serve as an in situ vaccine and synergize with local radiotherapy (RT) to induce T cell ...
Noah Tsarovsky, Mildred Felder, Mackenzie Heck, Jacob Slowinski, Kayla Rasmussen, Sabrina VandenHeuvel, Jen Zaborek, Zachary S. Morris, Zachary S. Morris, Amy K. Erbe, Amy K. Erbe, Paul M. Sondel, Paul M. Sondel, Paul M. Sondel, Alexander L. Rakhmilevich, Alexander L. Rakhmilevich   +15 more
doaj   +1 more source

Protocol schema for tumor-bearing companion dogs receiving external beam radiation therapy in combination with intratumoral hu14.18-IL2 immunocytokine and ^86/90Y-NM600 targeted radionuclide therapy.

, 2021
Protocol schema for tumor-bearing companion dogs receiving external beam radiation therapy in combination with intratumoral hu14.18-IL2 immunocytokine and 86/90Y-NM600 targeted radionuclide therapy.
Zachary S. Morris (6287090), Christine Jaskowiak (11268701), Eduardo Aluicio-Sarduy (1610008), Ilene D. Kurzman (11268692), Joseph Grudzinski (11268689), Jonathan W. Engle (325235), Elizabeth A. Oseid (11268698), Michelle M. Turek (11268686), Mark R. Albertini (11268704), David M. Vail (11268710), Paul M. Sondel (5408369), Kara Magee (11268683), Cindy L. Zuleger (11268695), Karla Esbona (3580781), Reinier Hernandez (1329030), Ian R. Marsh (3041166), Bryan Bednarz (11268707), Jamey P. Weichert (400808)   +17 more
core   +1 more source

[68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice

Frontiers in Immunology, 2022
Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule, which supports contact between leukocytes and inflamed endothelium.
Riikka Viitanen, Helena Virtanen, Heidi Liljenbäck, Heidi Liljenbäck, Olli Moisio, Xiang-Guo Li, Xiang-Guo Li, Xiang-Guo Li, Valeria Nicolini, Marine Richard, Christian Klein, Tapan Nayak, Sirpa Jalkanen, Sirpa Jalkanen, Anne Roivainen, Anne Roivainen, Anne Roivainen, Anne Roivainen   +17 more
doaj   +1 more source

Immunotoxines et immunocytokines [PDF]

médecine/sciences, 2019
Les cytokines et les toxines biologiques représentent deux classes de biomolécules qui ont longtemps été explorées pour leur potentiel thérapeutique. Des effets secondaires considérables et des mauvaises propriétés pharmacocinétiques sont fréquemment observés chez chacune d’elles, ce qui limite leur application. L’ingénierie des protéines recombinantes
Alicia Contet, Véronique Caussanel, Alain Beck, Peter Lowe   +3 more
openaire   +1 more source