Results 11 to 20 of about 129,949 (299)

Immunogenic Cell Death Induction by Ionizing Radiation [PDF]

Frontiers in Immunology, 2021
Immunogenic cell death (ICD) is a form of regulated cell death (RCD) induced by various stresses and produces antitumor immunity via damage-associated molecular patterns (DAMPs) release or exposure, mainly including high mobility group box 1 (HMGB1 ...
Mengqin Zhu, Mengqin Zhu, Mengdie Yang, Mengdie Yang, Jiajia Zhang, Jiajia Zhang, Yuzhen Yin, Yuzhen Yin, Xin Fan, Xin Fan, Yu Zhang, Yu Zhang, Shanshan Qin, Shanshan Qin, Han Zhang, Han Zhang, Fei Yu, Fei Yu   +17 more
doaj   +3 more sources

Dynamical Boolean Modeling of Immunogenic Cell Death [PDF]

Frontiers in Physiology, 2020
As opposed to the standard tolerogenic apoptosis, immunogenic cell death (ICD) constitutes a type of cellular demise that elicits an adaptive immune response.
Andrea Checcoli, Jonathan G. Pol, Jonathan G. Pol, Aurelien Naldi, Vincent Noel, Vincent Noel, Vincent Noel, Emmanuel Barillot, Emmanuel Barillot, Emmanuel Barillot, Guido Kroemer, Guido Kroemer, Guido Kroemer, Guido Kroemer, Guido Kroemer, Denis Thieffry, Laurence Calzone, Laurence Calzone, Laurence Calzone, Gautier Stoll, Gautier Stoll   +20 more
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Immunogenic Cell Death in Hematological Malignancy Therapy

Advanced Science, 2023
Although the curative effect of hematological malignancies has been improved in recent years, relapse or drug resistance of hematological malignancies will eventually recur.
Zhaoyun Liu, Xintong Xu, Kaining Liu, Jingtian Zhang, Dan Ding, Rong Fu   +5 more
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Lysosomal lipid peroxidation mediates immunogenic cell death

The Journal of Clinical Investigation, 2023
Cancer cells rely on lysosome-dependent degradation to recycle nutrients that serve their energetic and biosynthetic needs. Despite great interest in repurposing the antimalarial hydroxychloroquine as a lysosomal inhibitor in clinical oncology trials ...
Pravin Phadatare, Jayanta Debnath
doaj   +3 more sources

Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib

Frontiers in Oncology, 2021
Cabozantinib (XL-184) is a multitarget tyrosine kinase inhibitor (TKI) targeting receptor tyrosine kinases (RTKs) involved in oncogenesis and angiogenesis.
Fabio Scirocchi, Chiara Napoletano, Angelica Pace, Hassan Rahimi Koshkaki, Alessandra Di Filippo, Ilaria Grazia Zizzari, Marianna Nuti, Aurelia Rughetti   +7 more
doaj   +4 more sources

Tumor-intrinsic determinants of immunogenic cell death modalities [PDF]

OncoImmunology, 2021
The immune system can recognize tumor cells to mount antigen-specific T cell response. Central to the establishment of T cell-mediated adaptive immunity are the inflammatory events that facilitate antigen presentation by stimulating the expression of MHC
Samuel T Workenhe, Jonathan Pol, Guido Kroemer   +2 more
doaj   +4 more sources

Immunogenicity of cell death driven by immune effectors [PDF]

Journal for ImmunoTherapy of Cancer, 2020
Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic per se has been a matter of intense debate. Two back-to-back papers from the Melero’s and Pardo’s groups have now resolved this conundrum, demonstrating that T ...
Lorenzo Galluzzi, Guido Kroemer, Giulia Petroni   +2 more
doaj   +3 more sources

Immunogenic Cell Death and Immunotherapy of Multiple Myeloma [PDF]

Frontiers in Cell and Developmental Biology, 2019
Over the past decades, immunotherapy has demonstrated a prominent clinical efficacy in a wide variety of human tumors. For many years, apoptosis has been considered a non-immunogenic or tolerogenic process whereas necrosis or necroptosis has long been ...
Alfonso Serrano-del Valle, Alberto Anel, Javier Naval, Isabel Marzo   +3 more
doaj   +5 more sources

Nanocarrier-Mediated Immunogenic Cell Death for Melanoma Treatment

International Journal of Nanomedicine, 2023
Jiandong Wang,1– 3,* Jinyuan Ma,1,4,* Zongguang Tai,1,4,* Lisha Li,1,4 Tingrui Zhang,1,4 Tingting Cheng,1– 3 Junxia Yu,1– 3 Quangang Zhu,1,4 Leilei Bao,2 Zhongjian Chen1,4 1Shanghai Skin Disease Hospital, School of Medicine, Tongji University,
Wang J, Ma J, Tai Z, Li L, Zhang T, Cheng T, Yu J, Zhu Q, Bao L, Chen Z   +9 more
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Targeting immunogenic cell death in cancer [PDF]

Molecular Oncology, 2020
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic therapy, and radiotherapy. It involves the activation of the immune system against cancer in immunocompetent hosts.
Ahmed, Asma, Tait, Stephen W.G.
openaire   +3 more sources