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Immunogenic and tolerogenic cell death [PDF]

Nature Reviews Immunology, 2009
The immune system is routinely exposed to dead cells during normal cell turnover, injury and infection. Mechanisms must exist to discriminate between different forms of cell death to correctly eliminate pathogens and promote healing while avoiding responses to self, which can result in autoimmunity.
Green, Douglas R., Ferguson, Thomas, Zitvogel, Laurence, Kroemer, Guido   +3 more
openaire   +2 more sources

Immunogenicity of necrotic cell death [PDF]

Cellular and Molecular Life Sciences, 2014
The mode of tumor cell death has significant effects on anti-tumor immunity. Although, previously it was thought that cell death is an inert effect, different investigators have clearly shown that dying tumors can attract, activate and mature professional antigen presenting cells and dendritic cells.
Jaba, Gamrekelashvili, Tim F, Greten, Firouzeh, Korangy   +2 more
openaire   +2 more sources

Immunogenic cell death in cancer immunotherapy

BMB Reports, 2023
Cancer immunotherapy has been acknowledged as a new paradigm for cancer treatment, with notable therapeutic effects on certain cancer types. Despite their significant potential, clinical studies over the past decade have revealed that cancer immunotherapy has low response rates in the majority of solid tumors.
Minji Choi, Jisoo Shin, Chae-Eun Lee, Joo-Yoon Chung, Minji Kim, Xiuwen Yan, Wen-Hao Yang, Jong-Ho Cha   +7 more
openaire   +2 more sources

Immunogenic cell death in radiation therapy [PDF]

OncoImmunology, 2013
Radiation therapy has been extensively employed throughout the last century to treat individuals affected by multiple types of tumors, with a variable degree of success. Current estimates indicate indeed that at least 50% of cancer patients all confounded have been or will be exposed to ionizing irradiation, either as a standalone intervention or ...
Galluzzi, Lorenzo, Kepp, Oliver, Kroemer, Guido   +2 more
openaire   +2 more sources

Immunogenic Cell Death in Cancer Therapy

Acta Naturae, 2022
Apoptosis plays a crucial role in chemotherapy-induced cell death. The conventional theory holding that apoptosis needs to be immunologically silent has recently been revised, and the concept of immunogenic cell death (ICD) has been proposed. This review describes the main features of ICD induction. These ICD markers are important for the effectiveness
Olga S. Troitskaya, Diana D. Novak, Vladimir A. Richter, Olga A. Koval   +3 more
openaire   +2 more sources

Viral subversion of immunogenic cell death [PDF]

Cell Cycle, 2009
While physiological cell death is non-immunogenic, pathogen induced cell death can be immunogenic and hence stimulate an immune response against antigens that derive from dying cells and are presented by dendritic cells (DCs). The obligate immunogenic "eat-me" signal generated by dying cells consists in the exposure of calreticulin (CRT) at the cell ...
Oliver, Kepp, Laura, Senovilla, Lorenzo, Galluzzi, Theocharis, Panaretakis, Antoine, Tesniere, Frederic, Schlemmer, Frank, Madeo, Laurence, Zitvogel, Guido, Kroemer   +8 more
openaire   +2 more sources

Immunogenic cell death

The International Journal of Developmental Biology, 2015
Currently, it is widely acknowledged that a proactive anticancer immunosurveillance mechanism takes part in the rejection of neoplastic lesions before they progress towards a benign or malignant tumour. However in cases of very aggressive neoplastic lesions consisting of cells with high mutational diversity, cancer cell variants might be formed that ...
Garg, Abhishek, Dudek-Peric, Aleksandra M., Romano, Erminia, Agostinis, Patrizia   +3 more
openaire   +4 more sources

The convergence of radiation and immunogenic cell death signaling pathways. [PDF]

, 2012
Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms ...
Barcellos-Hoff, Mary H, Demaria, Sandra, Formenti, Silvia C, Golden, Encouse B, Pellicciotta, Ilenia   +4 more
core   +2 more sources

Inhibitory DAMPs in immunogenic cell death and its clinical implications

Cell Stress, 2021
Dying (or dead) cells are increasingly recognized to impose significant biological influence within their tissues of residence—exerting paracrine effects through proteins and metabolites that are expressed or secreted during cellular demise. For example,
Kazukuni Hayashi, Fotis Nikolos, Keith S. Chan   +2 more
doaj   +1 more source

Inhibition of HIF-1 alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma [PDF]

, 2015
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Acland, Assenat, Bazhin, Carbone, Chaput, Chen, Chouaib, Danenberg, David, Dyson, El-Deiry, Gallick, Gelovani, Ghansah, Giese, Gil, Gress, Gribben, Hao, Hao, Hao, Henson, Jemal, Kiessling, Kroemer, Kroemer, Kroemer, Levi, Luo, Mi, Moses, Plate, Powis, Powis, Powis, Ravichandran, Ricci, Rodeck, Sarker, Schuler, Semenza, Singh, Spisek, Tani, Vandenabeele, Wang, Wang, Zitvogel, Zitvogel, Zitvogel   +49 more
core   +1 more source