Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]
, 2017 Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana +5 more
core +1 more source
Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future [PDF]
, 2015 Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy.
CIRONE, Mara +6 more
core +4 more sources
Nanotechnology-Assisted Immunogenic Cell Death for Effective Cancer Immunotherapy
Vaccines, 2023 Tumor vaccines have been used to treat cancer. How to efficiently induce tumor-associated antigens (TAAs) secretion with host immune system activation is a key issue in achieving high antitumor immunity. Immunogenic cell death (ICD) is a process in which
Yichen Guo +5 more
doaj +1 more source
A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma [PDF]
, 2015 Means to cause an immunogenic cell death could lead to significant insight into how cancer escapes immune control. In this study, we screened a library of five pyrrole–imidazole polyamides coding for different DNA sequences in a model of B-cell lymphoma ...
Dervan, Peter B., Kang, JeenJoo S.
core +3 more sources
Bortezomib Induces Immunogenic Cell Death in Multiple Myeloma [PDF]
Blood Cancer Discovery, 2021 Abstract Summary: As a general rule, successful antineoplastic treatments induce an antitumor immune response, even if they were initially designed to target cancer cell–autonomous pathways. In this issue of Blood Cancer Discovery, Gulla and colleagues reveal that the proteasome inhibitor bortezomib ...
Laurence, Zitvogel, Guido, Kroemer
openaire +2 more sources
Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors
OncoImmunology, 2018 Immunogenic cell death is characterized by the emission of danger signals that facilitate activation of an adaptive immune response against dead-cell antigens.
Abraham G. Lin +7 more
doaj +1 more source
Immunogenic effects of chemotherapy-induced tumor cell death
Genes and Diseases, 2018 Emerging evidence suggests that the clinical success of conventional chemotherapy is not solely attributed to tumor cell toxicity, but also results from the restoration of immunosurveillance, which has been largely neglected in the past preclinical and ...
Yi-Jun Wang +3 more
doaj +1 more source
The acceleration of metastases after tumor removal and the paradoxical phenomenon of concomitant tumor resistance [PDF]
, 2018 Although surgical extirpation of tumors is usually clinically recommended, tumor removal may entail an undesired side effect: the risk of accelerating the growth of metastases.
Chiarella, Paula +3 more
core +1 more source
Immunogenic cell death: The cornerstone of oncolytic viro-immunotherapy
Frontiers in Immunology, 2023 According to the World Health Organization, cancer is one of the leading global health concerns, causing nearly 10 million deaths in 2020. While classical chemotherapeutics produce strong cytotoxicity on cancer cells, they carry limitations of drug ...
Lalitha Palanivelu +5 more
doaj +1 more source
Trial watch: chemotherapy-induced immunogenic cell death in oncology
OncoImmunology, 2023 Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated cell death that activates, rather than suppresses, innate and adaptive immune responses. Such responses culminate into T cell-driven immunity against antigens derived
Jenny Sprooten +26 more
doaj +1 more source