Results 21 to 30 of about 57,044 (253)

Atypical intestinal alpha-chain disease evolving into selective immunoglobulin A deficiency in a Finnish boy

Gastroenterology, 1980
The clinical course of alpha-chain disease in a Finnish boy is described. The disease presented with growth retardation and gastrointestinal symptoms at age 10 yr. Tests performed between the ages of 15 and 21 yr showed varying intestinal involvement including the large bowel, ileum, and distal jejunum.
E, Savilahti, P, Brandtzaeg, P, Kuitunen
openaire   +2 more sources

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna, Delles, Christian, Filip, Szymon, Gakiopoulou, Chara, Jankowski, Joachim, Krochmal, Magdalena, Markoska, Katerina, Mischak, Harald, Orange, Clare, Spasovski, Goce, Vlahou, Antonia, Zoidakis, Jerome   +11 more
core   +2 more sources

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans [PDF]

, 2013
Rabies kills many people throughout the developing world every year. The murine monoclonal antibody (mAb) 62-71-3 was recently identified for its potential application in rabies postexposure prophylaxis (PEP).
Anthony R. Fooks, Ashley C. Banyard, Bardor M., Benmansour A., Bianca Bulmer‐Thomas, Constantine D. G., Craig Dolleweerd, David Selden, Dietzschold B., Dietzschold B., Dietzschold B., Edward Wright, Fooks A. R., Friedrich Altmann, Gomord V., Hampson K., Hultberg A., Julian K.‐C. Ma, Knobel D. L., Lafay F., Lafon M., Leonard Both, Luo T. R., Ma J. K., Manning S. E., Mansfield K. L., McCormick A. A., Muhamuda K., Müller T., Prehaud C., Satpathy D. M., Seif I., Shantavasinkul P., Sudarshan M. K., Tacket C. O., Tekoah Y., Van Ree R., Warrell M., Wertheim H. F. L., World Health Organization, World Health Organization, Wright E., Zeitlin L.   +42 more
core   +1 more source

The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]

, 2003
We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Hadlington, Jane L., Santoro, Aniello, Nuttall, James, Denecke, J. (Jurgen), Ma, Julian K.-C., Vitale, A. (Alessandro), Frigerio, Lorenzo   +6 more
core   +1 more source

VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins [PDF]

, 2015
Peer reviewedPublisher ...
Clem, Flajnik, Makrides, Marchalonis, Müller   +4 more
core   +3 more sources

Characterization of truncated alpha chain products from human, rat, and mouse high affinity receptor for immunoglobulin E

Journal of Biological Chemistry, 1991
The high affinity receptor for immunoglobulin E (IgE) is a tetrameric structure (alpha beta gamma 2) consisting of non-covalently associated subunits: one IgE-binding alpha chain, one 4-fold membrane spanning beta chain, and two disulfide-linked gamma chains.
U, Blank, C S, Ra, J P, Kinet
openaire   +2 more sources

Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions. [PDF]

The Journal of experimental medicine, 1996
The high-affinity receptor for immunoglobulin (Ig) E (Fc epsilon RI) on mast cells and basophils plays a key role in IgE-mediated allergies. Fc epsilon RI is composed of one alpha, one beta, and two gamma chains, which are all required for cell surface expression of Fc epsilon RI, but only the alpha chain is involved in the binding to IgE.
W P, Fung-Leung, J, De Sousa-Hitzler, A, Ishaque, L, Zhou, J, Pang, K, Ngo, J A, Panakos, E, Chourmouzis, F T, Liu, C Y, Lau   +9 more
openaire   +2 more sources

Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy [PDF]

, 1984
Post-transplant lymphomas or other lymphoproliferative lesions, which were usually associated with Epstein-Barr virus infections, developed in 8, 4, 3, and 2 recipients, respectively, of cadaveric kidney, liver, heart, and heart-lung homografts ...
Atchison, RW, Bahnson, HT, Griffith, BP, Hakala, TR, Hardesty, RL, Ho, M, Iwatsuki, S, Jaffe, R, Nalesnik, MA, Porter, KA, Rosenthal, JT, Shaw, BW, Starzl, TE   +12 more
core   +1 more source

Biogenesis of membrane-bound and secreted immunoglobulins. II. Two forms of the human alpha chain translated in vitro and processed in vivo as distinct polypeptide chains. [PDF]

The Journal of experimental medicine, 1981
Structural differences between alpha m (ther heavy chain of membrane IgA) and alpha s (the heavy chain of secretory IgA) were investigated. Messenger RNA from the human B lymphoblastoid line 32a.1, expressing both membrane and secretory IgA, was translated in a wheat germ cell-free system, resulting in the synthesis of two primary translation products ...
J M, McCune, S M, Fu, G, Blobel, H G, Kunkel   +3 more
openaire   +2 more sources

A Case Report of Atypical Presentation of Multiple Myeloma on Serum Protein Electrophoresis [PDF]

Journal of Krishna Institute of Medical Sciences University, 2018
Multiple myeloma is a group of B-cell disorders resulting in the secretion of a specific and unique monoclonal immunoglobulin (M-protein). Protein electrophoresis is advised whenever multiple myeloma is suspected.
Pooja P. Padasal, Anil Malleshappa
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