Results 1 to 10 of about 76,198 (186)

13C NMR study of the mode of interaction in solution of the B fragment of staphylococcal protein A and the Fc fragments of mouse immunoglobulin G [PDF]

FEBS Letters, 1923
The mode of interaction of the B domain (FB) of staphylococcal protein A and the Fc fragments of mouse immunoglobulin G (IgG) has been investigated by 13C NMR spectroscopy.
Langone, Burton, Moks, Deisenhofer, Gouda, Sjöholm, Wright, Lancet, Kato, Matsunaga, Kim, Nagasawa, Saito, Torigoe, Dangl, Dangl, Kainosho, Barnett-Fostar, Ey, Schneider, Edelman, Kabat, Igarashi   +22 more
core   +2 more sources

Immunoglobulin Fc heterodimer platform technology: From design to applications in therapeutic antibodies and proteins

Frontiers in Immunology, 2016
The monospecific and bivalent characteristics of naturally occurring immunoglobulin G (IgG) antibodies depend on homodimerization of the fragment crystallizable (Fc) regions of two identical heavy chains (HCs) and the subsequent assembly of two identical
Ji-Hee Ha, Jung-Eun Kim, Yong-Sung Kim
doaj   +2 more sources

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Nature Communications, 2022
Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus, Erwin Pannecoucke, Elvera J. van der Kooi, Arthur E. H. Bentlage, Ninotska I. L. Derksen, Julie Andries, Bianca Balbino, Magdalena Sips, Peter Ulrichts, Peter Verheesen, Hans de Haard, Theo Rispens, Savvas N. Savvides, Gestur Vidarsson   +13 more
doaj   +2 more sources

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

Frontiers in Immunology, 2017
Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke, Christian W. Keller, Patrick Weber, Isaak Quast, Isaak Quast, Jan D. Lünemann, Jan D. Lünemann   +6 more
doaj   +2 more sources

The herpes virus Fc receptor gE-gI mediates antibody bipolar bridging to clear viral antigens from the cell surface. [PDF]

PLoS Pathogens, 2014
The Herpes Simplex Virus 1 (HSV-1) glycoprotein gE-gI is a transmembrane Fc receptor found on the surface of infected cells and virions that binds human immunoglobulin G (hIgG).
Blaise Ndjamen, Alexander H Farley, Terri Lee, Scott E Fraser, Pamela J Bjorkman   +4 more
doaj   +11 more sources

Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds [PDF]

Frontiers in Immunology, 2017
Therapeutic monoclonal antibodies have become molecules of choice to treat autoimmune disorders, inflammatory diseases, and cancer. Moreover, bispecific/multispecific antibodies that target more than one antigen or epitope on a target cell or recruit ...
Abhishek Saxena, Donghui Wu, Hongyan Liu, Sachdev S. Sidhu   +3 more
core   +2 more sources

Effect of IgG fragments in IVIG(pH4)on phagocytosis of sensitized erythrocytes by macrophage

Zhongguo shuxue zazhi, 2022
Objective To research the effect of the Fc, Fab and F(ab′)2 fragments of immunoglobulin G, the main components of Human Immunoglobulin(pH4) for Intravenous Injection(IVIG), on the phagocytic function of macrophages derived from THP-1 cells. Methods First
Liyuan ZHU, Wei ZHANG, Mingxia HOU, Qin LIU, Yuyan QIN, Li Ma, Changqing LI   +6 more
doaj   +1 more source

The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies

Frontiers in Immunology, 2021
Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies.
C. Monnet, E. Jacque, C. de Romeuf, A. Fontayne, Toufik Abache, N. Fournier, G. Dupont, Delphine Derache, Anaïs Engrand, Aurélie Bauduin, Aurélie Terrier, Alexander Seifert, Cécile Beghin, Alain Longue, N. Masiello, Laetitia Danino, M. Nogré, Anais Raia, F. Dhainaut, L. Fauconnier, D. Togbe, C. Reitinger, F. Nimmerjahn, W. Stevens, S. Chtourou, P. Mondon   +25 more
semanticscholar   +1 more source

Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing

Scientific Reports, 2021
A major class of bispecific antibodies (BsAbs) utilizes heterodimeric Fc to produce the native immunoglobulin G (IgG) structure. Because appropriate pairing of heavy and light chains is required, the design of BsAbs produced through recombination or ...
Hiroki Akiba, Tomoko Ise, Satoshi Nagata, Haruhiko Kamada, Hiroaki Ohno, Kouhei Tsumoto   +5 more
doaj   +1 more source

Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1

Frontiers in Immunology, 2021
The tumor microenvironment (TME) is a complex structure comprised of tumor, immune and stromal cells, vasculature, and extracellular matrix (ECM). During tumor development, ECM homeostasis is dysregulated. Collagen remodeling by matrix metalloproteinases
Saskia V. Vijver, Saskia V. Vijver, Akashdip Singh, Akashdip Singh, Eline T. A. M. Mommers-Elshof, Eline T. A. M. Mommers-Elshof, Jan Meeldijk, Ronald Copeland, Louis Boon, Sol Langermann, Dallas Flies, Linde Meyaard, Linde Meyaard, M. Inês Pascoal Ramos, M. Inês Pascoal Ramos   +14 more
doaj   +1 more source