Interactions among rheumatoid synovial cells and monocyte-macrophages: production of collagenase-stimulating factor by human monocytes exposed to concanavalin A or immunoglobulin Fc fragments. [PDF]
Journal of Immunology, 1980 Adherent synovial cells (ASC) were obtained from minced synovium from patients with rheumatoid arthritis by dissociating the lining cells from the extracellular matrix and dispersing them with proteases.
J.-M. Dayer +3 more
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Frontiers in Immunology, 2016 The monospecific and bivalent characteristics of naturally occurring immunoglobulin G (IgG) antibodies depend on homodimerization of the fragment crystallizable (Fc) regions of two identical heavy chains (HCs) and the subsequent assembly of two identical
Ji-Hee Ha, Jung-Eun Kim, Yong-Sung Kim
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Инфекция и иммунитет, 2020 The pathogenesis of poststreptococcal glomerulonephritis (PSGN), a major complication of acute infections caused by group A streptococci (GAS) remains unclear.
L. A. Burova +3 more
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The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement
Nature Communications, 2022 Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus +13 more
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Frontiers in Immunology, 2017 Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke +6 more
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Subfragments from the Fc fragment of human immunoglobulin G. Isolation and physicochemical characterization [PDF]
Biochemical Journal, 1968 A fragment termed fragment Fc′ and a related fragment termed fragment pFc′ produced by the actions of papain and pepsin respectively on human immunoglobulin G have been isolated and characterized. Amino acid analyses and experiments utilizing cyanogen bromide to cleave the methionyl bonds of the Fc′ and pFc′ fragments make it possible to locate both ...
Malcolm Turner, H. Bennich
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Immunoglobulin G Fc Fragment‐Binding Proteins in Mycoplasma salivarium Cells [PDF]
Microbiology and Immunology, 1992 AbstractCell proteins of Mycoplasma salivarium were separated by sodium dodecyl sulfate‐polyacrylamide gel electrophoresis, transferred to membranes, then examined for reactivity with human IgG molecules, the Fc fragment of human IgG, and concanavalin A (ConA). Multiple protein bands bound IgG, and most of them also bound ConA.
Yoshihiko Sawa +2 more
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Conformation changes and dissociation of Fc fragments of rabbit immunoglobulin G as a function of pH. [PDF]
Biochemical Journal, 1969 1. The sedimentation coefficients of rabbit immunoglobulin G, four types of Fc fragments, univalent Fab and bivalent F(ab)2 fragments were measured as a function of pH. 2. In conjunction with molecular-weight determinations by sedimentation equilibrium, and with the behaviour on gel filtration, this enabled the state of association of the Fc fragments ...
P. Charlwood, S. Utsumi
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Enzymic degradation of the Fc fragment of rabbit immunoglobulin IgG [PDF]
Biochemical Journal, 1967 The digestion of the Fc fragment of rabbit immunoglobulin IgG by several proteolytic enzymes was investigated by using gel filtration and starch-gel electrophoresis in 8m-urea-formate as criteria of the extent of degradation. Though fragment Fc and mildly reduced fragment Fc proved resistant to tryptic hydrolysis, papain and pepsin cleaved the fragment
Prahl Jw
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Anti-immunoglobulin antibodies. III. Properties of sequential anti-idiotypic antibodies to heterologous anti-gamma globulins. Detection of reactivity of anti-idiotype antibodies with epitopes of Fc fragments (homobodies) and with epitopes and idiotopes (epibodies). [PDF]
Journal of Experimental Medicine, 1982 Murine anti-V region antibodies against a human monoclonal protein Gl with anti-gamma-globulin activity and bearing the Wa cross-reactive idiotype were prepared in several strains of mice.
Constantin A. Bona +3 more
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