Results 1 to 10 of about 51,720 (301)

13C NMR study of the mode of interaction in solution of the B fragment of staphylococcal protein A and the Fc fragments of mouse immunoglobulin G [PDF]

FEBS Letters, 1923
The mode of interaction of the B domain (FB) of staphylococcal protein A and the Fc fragments of mouse immunoglobulin G (IgG) has been investigated by 13C NMR spectroscopy.
Langone, Burton, Moks, Deisenhofer, Gouda, Sjöholm, Wright, Lancet, Kato, Matsunaga, Kim, Nagasawa, Saito, Torigoe, Dangl, Dangl, Kainosho, Barnett-Fostar, Ey, Schneider, Edelman, Kabat, Igarashi   +22 more
core   +7 more sources

Altered IgG N-Glycosylation at Onset of Type 1 Diabetes in Children Is Predominantly Driven by Changes in the Fab N-Glycans [PDF]

Biomedicines
Background: N-glycosylation is a post-translational modification involving the attachment of oligosaccharides to proteins and is known to influence immunoglobulin G (IgG) effector functions and even antigen binding.
Branimir Plavša, Najda Rudman, Flemming Pociot, Olga Gornik   +3 more
doaj   +2 more sources

The herpes virus Fc receptor gE-gI mediates antibody bipolar bridging to clear viral antigens from the cell surface. [PDF]

PLoS Pathogens, 2014
The Herpes Simplex Virus 1 (HSV-1) glycoprotein gE-gI is a transmembrane Fc receptor found on the surface of infected cells and virions that binds human immunoglobulin G (hIgG).
Blaise Ndjamen, Alexander H Farley, Terri Lee, Scott E Fraser, Pamela J Bjorkman   +4 more
doaj   +11 more sources

Impact of IgG Fc-fragments on experimental glomerulonephritis induced by Streptococcus pyogenes strain binding various immunoglobulin classes

Инфекция и иммунитет, 2020
The pathogenesis of poststreptococcal glomerulonephritis (PSGN), a major complication of acute infections caused by group A streptococci (GAS) remains unclear.
L. A. Burova, P. V. Pigarevsky, V. A. Snegova, A. A. Totolian   +3 more
doaj   +3 more sources

Effect of IgG fragments in IVIG(pH4)on phagocytosis of sensitized erythrocytes by macrophage

Zhongguo shuxue zazhi, 2022
Objective To research the effect of the Fc, Fab and F(ab′)2 fragments of immunoglobulin G, the main components of Human Immunoglobulin(pH4) for Intravenous Injection(IVIG), on the phagocytic function of macrophages derived from THP-1 cells. Methods First
Liyuan ZHU, Wei ZHANG, Mingxia HOU, Qin LIU, Yuyan QIN, Li Ma, Changqing LI   +6 more
doaj   +1 more source

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Nature Communications, 2022
Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus, Erwin Pannecoucke, Elvera J. van der Kooi, Arthur E. H. Bentlage, Ninotska I. L. Derksen, Julie Andries, Bianca Balbino, Magdalena Sips, Peter Ulrichts, Peter Verheesen, Hans de Haard, Theo Rispens, Savvas N. Savvides, Gestur Vidarsson   +13 more
doaj   +1 more source

Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing

Scientific Reports, 2021
A major class of bispecific antibodies (BsAbs) utilizes heterodimeric Fc to produce the native immunoglobulin G (IgG) structure. Because appropriate pairing of heavy and light chains is required, the design of BsAbs produced through recombination or ...
Hiroki Akiba, Tomoko Ise, Satoshi Nagata, Haruhiko Kamada, Hiroaki Ohno, Kouhei Tsumoto   +5 more
doaj   +1 more source

Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1

Frontiers in Immunology, 2021
The tumor microenvironment (TME) is a complex structure comprised of tumor, immune and stromal cells, vasculature, and extracellular matrix (ECM). During tumor development, ECM homeostasis is dysregulated. Collagen remodeling by matrix metalloproteinases
Saskia V. Vijver, Saskia V. Vijver, Akashdip Singh, Akashdip Singh, Eline T. A. M. Mommers-Elshof, Eline T. A. M. Mommers-Elshof, Jan Meeldijk, Ronald Copeland, Louis Boon, Sol Langermann, Dallas Flies, Linde Meyaard, Linde Meyaard, M. Inês Pascoal Ramos, M. Inês Pascoal Ramos   +14 more
doaj   +1 more source

Immuno-capture of biomolecules on functionalized magnetic beads: From characterization to fluorescent detection of a biomarker for Alzheimer's disease toward high performance biosensing

Talanta Open, 2023
It is reported herein a new approach to study the orientation and density of mouse antibody grafting on magnetic beads, serving for immunoassays and biosensors with fluorescent detection of biomolecules.
Ngoc Van Thanh Nguyen, Claire Smadja, Myriam Taverna, Trong Khoa Mai, Frédéric Halgand, Thanh Duc Mai   +5 more
doaj   +1 more source

The mosaic puzzle of the therapeutic monoclonal antibodies and antibody fragments - A modular transition from full-length immunoglobulins to antibody mimetics

Leukemia Research Reports, 2022
The use of monoclonal antibodies represents an important and efficient diagnostic and therapeutic tool in disease management and modern science but remains limited by several factors including the uneven distribution in diseased tissues as well as ...
Sami El Khatib, Mohamed Salla
doaj   +1 more source