Results 1 to 10 of about 45,350 (212)
Conformation changes and dissociation of Fc fragments of rabbit immunoglobulin G as a function of pH [PDF]
Biochemical Journal, 1969 1. The sedimentation coefficients of rabbit immunoglobulin G, four types of Fc fragments, univalent Fab and bivalent F(ab)2 fragments were measured as a function of pH. 2. In conjunction with molecular-weight determinations by sedimentation equilibrium, and with the behaviour on gel filtration, this enabled the state of association of the Fc fragments ...
P. A. Charlwood, S Utsumi
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13C NMR study of the mode of interaction in solution of the B fragment of staphylococcal protein A and the Fc fragments of mouse immunoglobulin G [PDF]
FEBS Letters, 1993 The mode of interaction of the B domain (FB) of staphylococcal protein A and the Fc fragments of mouse immunoglobulin G (IgG) has been investigated by 13C NMR spectroscopy. Mouse IgG1, IgG2a, and IgG2b proteins have been selectively labeled with 13C at the carbonyl carbon of His, Met, Trp or Tyr residue and used to prepare the corresponding Fc ...
Koichi Kato +5 more
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ROLE OF Fc FRAGMENTS IN INHIBITION OF XENOGENIC HYPERACUTE REJECTION BY INTRAVENOUS IMMUNOGLOBULIN
Transplantation, 1996 It has been shown that a high dose administration of human intravenous immunoglobulin G (IVIG) prolonged the survival time of xenografted guinea pig heart in the rat. In this study, we compared the effectiveness of intact IVIG (I-IVIG), Fc fragments of IVIG (Fc-IVIG), and F(ab') fragments of IVIG (Fab-IVIG) in preventing xenogenic hyperacute rejection ...
Taiki Kojima +3 more
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The Amino Acid Sequence of the Fc Fragment of Rabbit Immunoglobulin G [PDF]
Journal of Biological Chemistry, 1968 Reaction of S-carboxymethyl-Fc fragment from rabbit immunoglobulin G with cyanogen bromide cleaves the fragment into five unique peptides, each of which has been isolated by chromatographic methods. The amino acid composition of the five peptides accounts closely for the amino acid composition of the Fc fragment.
Robert Delaney, Robert L. Hill
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Interactions among rheumatoid synovial cells and monocyte-macrophages: production of collagenase-stimulating factor by human monocytes exposed to concanavalin A or immunoglobulin Fc fragments. [PDF]
Journal of Immunology, 1980 Adherent synovial cells (ASC) were obtained from minced synovium from patients with rheumatoid arthritis by dissociating the lining cells from the extracellular matrix and dispersing them with proteases.
J.-M. Dayer +3 more
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Frontiers in Immunology, 2016 The monospecific and bivalent characteristics of naturally occurring immunoglobulin G (IgG) antibodies depend on homodimerization of the fragment crystallizable (Fc) regions of two identical heavy chains (HCs) and the subsequent assembly of two identical
Ji-Hee Ha, Jung-Eun Kim, Yong-Sung Kim
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Reversible Dissociation of Fragment Fc of Rabbit γG-Immunoglobulin
Journal of Biological Chemistry, 1966 Abstract Crystallized Fragment Fc of rabbit γG-globulin, prepared by digestion with papain in the presence of 0.05 m l-cysteine, dissociates into half-fragments in 0.05 m NaCl at pH 2.7. Dissociation is approximately half-complete at pH 3.1. The conditions are similar to those required for dissociation of γG-globulin into half-molecules, which supports
F. P. Inman, Alfred Nisonoff
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The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement
Nature Communications, 2022 Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus +13 more
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Enzymic degradation of the Fc fragment of rabbit immunoglobulin IgG [PDF]
Biochemical Journal, 1967 The digestion of the Fc fragment of rabbit immunoglobulin IgG by several proteolytic enzymes was investigated by using gel filtration and starch-gel electrophoresis in 8m-urea-formate as criteria of the extent of degradation. Though fragment Fc and mildly reduced fragment Fc proved resistant to tryptic hydrolysis, papain and pepsin cleaved the fragment
Prahl Jw
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Subfragments from the Fc fragment of human immunoglobulin G. Isolation and physicochemical characterization [PDF]
Biochemical Journal, 1968 A fragment termed fragment Fc′ and a related fragment termed fragment pFc′ produced by the actions of papain and pepsin respectively on human immunoglobulin G have been isolated and characterized. Amino acid analyses and experiments utilizing cyanogen bromide to cleave the methionyl bonds of the Fc′ and pFc′ fragments make it possible to locate both ...
Malcolm Turner, H. Bennich
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