Results 31 to 40 of about 45,350 (212)

Immuno-capture of biomolecules on functionalized magnetic beads: From characterization to fluorescent detection of a biomarker for Alzheimer's disease toward high performance biosensing

Talanta Open, 2023
It is reported herein a new approach to study the orientation and density of mouse antibody grafting on magnetic beads, serving for immunoassays and biosensors with fluorescent detection of biomolecules.
Ngoc Van Thanh Nguyen, Claire Smadja, Myriam Taverna, Trong Khoa Mai, Frédéric Halgand, Thanh Duc Mai   +5 more
doaj   +1 more source

The mosaic puzzle of the therapeutic monoclonal antibodies and antibody fragments - A modular transition from full-length immunoglobulins to antibody mimetics

Leukemia Research Reports, 2022
The use of monoclonal antibodies represents an important and efficient diagnostic and therapeutic tool in disease management and modern science but remains limited by several factors including the uneven distribution in diseased tissues as well as ...
Sami El Khatib, Mohamed Salla
doaj   +1 more source

Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies

mAbs, 2023
T-cell-engaging bispecific antibodies (T-bsAbs) are promising immunotherapies for cancer treatment due to their capability of redirecting T-cells toward destroying tumor cells.
Han Ping Loh, Farouq Bin Mahfut, Serene W Chen, Yuhan Huang, Jianxin Huo, Wei Zhang, Kong Peng Lam, Shengli Xu, Yuansheng Yang   +8 more
doaj   +1 more source

Improvement of the method of obtaining human IgA Fc-fragments

Regulatory Mechanisms in Biosystems, 2015
To address a number of fundamental and applied problems in immunology, molecular and cellular biology and biotechnology it is necessary to obtain Fc-fragments of immunoglobulins.
O. Y. Galkin, Y. V. Gorshunov, V. F. Solovjova   +2 more
doaj   +1 more source

Activating FcγR function depends on endosomal-signaling platforms

iScience, 2023
Summary: Cell surface receptor internalization can either terminate signaling or activate alternative endosomal signaling pathways. We investigated here whether endosomal signaling is involved in the function of the human receptors for Fc immunoglobulin ...
Samira Benadda, Mathilde Nugue, Despoina Koumantou, Marcelle Bens, Mariacristina De Luca, Olivier Pellé, Renato C. Monteiro, Irini Evnouchidou, Loredana Saveanu   +8 more
doaj   +1 more source

Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice

Toxins, 2019
The bacterium Clostridium botulinum is the causative agent of botulism—a severe intoxication caused by botulinum neurotoxin (BoNT) and characterized by damage to the nervous system. In an effort to develop novel C.
S. A. Godakova, A. N. Noskov, I. D. Vinogradova, G. A. Ugriumova, A. Solovyev, I. Esmagambetov, A. Tukhvatulin, D. Logunov, B. Naroditsky, D. Shcheblyakov, A. Gintsburg   +10 more
semanticscholar   +1 more source

Full-length recombinant antibodies from Escherichia coli: production, characterization, effector function (Fc) engineering, and clinical evaluation

mAbs, 2022
Although several antibody fragments and antibody fragment-fusion proteins produced in Escherichia coli (E. coli) are approved as therapeutics for various human diseases, a full-length monoclonal or a bispecific antibody produced in E.
Md Harunur Rashid
doaj   +1 more source

Lupus serum IgG induces microglia activation through Fc fragment dependent way and modulated by B-cell activating factor

Journal of Translational Medicine, 2019
Background Neuropsychiatric manifestations are frequent in patients with systemic lupus erythematosus (SLE), yet the etiology and pathogenesis of brain damage in SLE remains unclear.
Chunshu Yang, Xiaoyu Hou, Qianhui Feng, Yingzhuo Li, Xuejiao Wang, Ling Qin, Pingting Yang   +6 more
doaj   +1 more source

Intracellular Antibodies for Drug Discovery and as Drugs of the Future

Antibodies, 2023
The application of antibodies in cells was first shown in the early 1990s, and subsequently, the field of intracellular antibodies has expanded to encompass antibody fragments and their use in target validation and as engineered molecules that can be ...
T. H. Rabbitts
doaj   +1 more source

Emerging therapies in the medical management of thyroid eye disease

Frontiers in Ophthalmology, 2023
IntroductionThyroid eye disease (TED) is an immune-mediated disorder associated with a heterogenous array of manifestations that may unfavorably impact vision and quality of life.
Alisha Kamboj, Andrew R. Harrison, Andrew R. Harrison, Ali Mokhtarzadeh   +3 more
doaj   +1 more source