Results 31 to 40 of about 90,091 (319)

Structural insights and biomedical potential of IgNAR scaffolds from sharks [PDF]

, 2014
Peer reviewedPublisher ...
Barelle, Caroline, Empting, Martin, Grzeschik, Julius, Kolmar, Harald, Könning, Doreen, Zielonka, Stefan   +5 more
core   +1 more source

The structure of human CD23 and its interactions with IgE and CD21 [PDF]

, 2005
The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcɛRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response.
Beavil, RL, Gould, HJ, Grundy, GJ, Hannan, JP, Hibbert, RG, Holers, VM, McDonnell, JM, Reljic, R, Sutton, BJ, Teriete, P   +9 more
core   +2 more sources

Impaired Immunoglobulin G Fc Fragment Function in Diabetics is Caused by a Mechanism Different from Glycation [PDF]

cclm, 1994
Glycation and fluorescence at 440 nm (excitation at 370 nm) were found to be increased in immunoglobulin G (IgG) from diabetics, strongly indicating the presence of IgG-linked advanced glycosylation end products. In contrast, levels of IgG-linked advanced glycosylation end products were low or undetectable in both normal and diabetic subjects when an ...
Roswitha Dolhofer-Bliesener, Brigitte Lechner, Klaus-Dieter Gerbitz   +2 more
openalex   +4 more sources

Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice

Toxins, 2019
The bacterium Clostridium botulinum is the causative agent of botulism—a severe intoxication caused by botulinum neurotoxin (BoNT) and characterized by damage to the nervous system. In an effort to develop novel C.
S. A. Godakova, A. N. Noskov, I. D. Vinogradova, G. A. Ugriumova, A. Solovyev, I. Esmagambetov, A. Tukhvatulin, D. Logunov, B. Naroditsky, D. Shcheblyakov, A. Gintsburg   +10 more
semanticscholar   +1 more source

Full-length recombinant antibodies from Escherichia coli: production, characterization, effector function (Fc) engineering, and clinical evaluation

mAbs, 2022
Although several antibody fragments and antibody fragment-fusion proteins produced in Escherichia coli (E. coli) are approved as therapeutics for various human diseases, a full-length monoclonal or a bispecific antibody produced in E.
Md Harunur Rashid
doaj   +1 more source

Intracellular Antibodies for Drug Discovery and as Drugs of the Future

Antibodies, 2023
The application of antibodies in cells was first shown in the early 1990s, and subsequently, the field of intracellular antibodies has expanded to encompass antibody fragments and their use in target validation and as engineered molecules that can be ...
T. H. Rabbitts
doaj   +1 more source

Stepwise cleavage of rabbit immunoglobulin G by papain and isolation of four types of biologically active Fc fragments.

Biochemical Journal, 1969
Four types of Fc fragments of different sizes were isolated by papain treatment of rabbit immunoglobulin G under various conditions and by subsequent chromatographic procedures. 1.
S. Utsumi
semanticscholar   +1 more source

Antibody degradation in tobacco plants: a predominantly apoplastic process. [PDF]

, 2011
BACKGROUND: Interest in using plants for production of recombinant proteins such as monoclonal antibodies is growing, but proteolytic degradation, leading to a loss of functionality and complications in downstream purification, is still a serious problem.
Drake, PM, Hehle, VK, Ma, JK, Paul, MJ, van Dolleweerd, CJ   +4 more
core   +2 more sources

A Fab-Selective Immunoglobulin-Binding Domain from Streptococcal Protein G with Improved Half-Life Extension Properties. [PDF]

PLoS ONE, 2015
Half-life extension strategies have gained increasing interest to improve the pharmacokinetic and pharmacodynamic properties of protein therapeutics. Recently, we established an immunoglobulin-binding domain (IgBD) from streptococcal protein G (SpGC3) as
Felix Unverdorben, Meike Hutt, Oliver Seifert, Roland E Kontermann   +3 more
doaj   +1 more source

Emerging therapies in the medical management of thyroid eye disease

Frontiers in Ophthalmology, 2023
IntroductionThyroid eye disease (TED) is an immune-mediated disorder associated with a heterogenous array of manifestations that may unfavorably impact vision and quality of life.
Alisha Kamboj, Andrew R. Harrison, Andrew R. Harrison, Ali Mokhtarzadeh   +3 more
doaj   +1 more source