Reversible Dissociation of Fragment Fc of Rabbit γG-Immunoglobulin
Journal of Biological Chemistry, 1966 Abstract Crystallized Fragment Fc of rabbit γG-globulin, prepared by digestion with papain in the presence of 0.05 m l-cysteine, dissociates into half-fragments in 0.05 m NaCl at pH 2.7. Dissociation is approximately half-complete at pH 3.1. The conditions are similar to those required for dissociation of γG-globulin into half-molecules, which supports
F.P. Inman, A. Nisonoff
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Studies on the immunoglobulin-G Fc-fragment receptor from neonatal rat small intestine [PDF]
Biochemical Journal, 1980 1. A method for preparing the small-intestinal brush-border membrane of neonatal rats is described in which enzymic methods are used to remove associated polysaccharide and cell nuclei. 2. 125I-labelled IgG (immunoglobulin G) and 125I-labelled IgG Fc fragment have high specific binding and low non-specific binding to brush borders prepared in this way.
K H, Wallace, A R, Rees
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mAbs, 2022 Multispecific therapeutic proteins come in a variety of formats, including bi- and tri-specific antibodies, dual-variable domain antibodies, and CrossMabs.
Jainik Panchal +3 more
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New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease [PDF]
, 2014 There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Fuller, James P. +2 more
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Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats
Frontiers in Molecular Biosciences, 2022 As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies and other new formats, represent a key component in advancing antibody therapy.
Monica L. Fernández-Quintero +11 more
doaj +1 more source
Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. [PDF]
, 1993 We have generated transgenic mice that express the immunoglobulin (Ig)M heavy chain and kappa light chain genes coding for a human IgM rheumatoid factor (RF), Les.
Carson, DA +6 more
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Fc N‐glycosylation of autoreactive Aβ antibodies as a blood‐based biomarker for Alzheimer's disease
Alzheimer's & Dementia, 2023 Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
Yannick Kronimus +16 more
semanticscholar +1 more source
Subfragments from the Fc fragment of human immunoglobulin G. Isolation and physicochemical characterization [PDF]
Biochemical Journal, 1968 A fragment termed fragment Fc′ and a related fragment termed fragment pFc′ produced by the actions of papain and pepsin respectively on human immunoglobulin G have been isolated and characterized. Amino acid analyses and experiments utilizing cyanogen bromide to cleave the methionyl bonds of the Fc′ and pFc′ fragments make it possible to locate both ...
M W, Turner, H, Bennich
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The structures of secretory and dimeric immunoglobulin A [PDF]
, 2020 Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds pathogens and commensal microbes. SIgA is a polymeric antibody, typically containing two copies of IgA that assemble with one joining-chain (JC) to form dimeric (d) IgA ...
Haloi, Nandan +6 more
core
Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli [PDF]
, 2014 Post-weaning diarrhea and edema disease caused by F18 fimbriated E. coli are important diseases in newly weaned piglets and lead to severe production losses in farming industry.
Coddens, Annelies +6 more
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