Results 41 to 50 of about 45,350 (212)

Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12

Cell Reports, 2013
The human immunoglobulin G (IgG) 2G12 recognizes high-mannose carbohydrates on the HIV type 1 (HIV-1) envelope glycoprotein gp120. Its two antigen-binding fragments (Fabs) are intramolecularly domain exchanged, resulting in a rigid (Fab)2 unit including ...
Yunji Wu, Anthony P. West, Jr., Helen J. Kim, Matthew E. Thornton, Andrew B. Ward, Pamela J. Bjorkman   +5 more
doaj   +1 more source

A Fab-Selective Immunoglobulin-Binding Domain from Streptococcal Protein G with Improved Half-Life Extension Properties. [PDF]

PLoS ONE, 2015
Half-life extension strategies have gained increasing interest to improve the pharmacokinetic and pharmacodynamic properties of protein therapeutics. Recently, we established an immunoglobulin-binding domain (IgBD) from streptococcal protein G (SpGC3) as
Felix Unverdorben, Meike Hutt, Oliver Seifert, Roland E Kontermann   +3 more
doaj   +1 more source

Anti-immunoglobulin antibodies. III. Properties of sequential anti- idiotypic antibodies to heterologous anti-gamma globulins. Detection of reactivity of anti-idiotype antibodies with epitopes of Fc fragments (homobodies) and with epitopes and idiotopes (epibodies)

Journal of Experimental Medicine, 1982
Murine anti-V region antibodies against a human monoclonal protein Gl with anti-gamma-globulin activity and bearing the Wa cross-reactive idiotype were prepared in several strains of mice.
C. Bona, S. Finley, S. Waters, H. Kunkel
semanticscholar   +1 more source

Production of highly and broad-range specific monoclonal antibodies against hemagglutinin of H5-subtype avian influenza viruses and their differentiation by mass spectrometry

Virology Journal, 2018
Background The highly pathogenic avian influenza viruses of the H5 subtype, such as the H5N1 viral strains or the novel H5N8 and H5N2 reassortants, are of both veterinary and public health concern worldwide. To combat these viruses, monoclonal antibodies
Violetta Sączyńska, Anna Bierczyńska-Krzysik, Violetta Cecuda-Adamczewska, Piotr Baran, Anna Porębska, Katarzyna Florys, Marcin Zieliński, Grażyna Płucienniczak   +7 more
doaj   +1 more source

Fc N‐glycosylation of autoreactive Aβ antibodies as a blood‐based biomarker for Alzheimer's disease

Alzheimer's & Dementia, 2023
Naturally occurring autoantibodies (nAbs) against the pathologic isoform of amyloid beta (Aβ42) were found in body fluids and indicate a systemic B cell response that may prevent Alzheimer's disease (AD) onset.
Yannick Kronimus, A. Albuş, M. Hasenberg, Bernd Walkenfort, M. Seifert, Bettina Budeus, J. Gronewold, Dirk M. Hermann, J. A. Ross, G. Lochnit, S. Galuska, K. Marcus, B. Sitek, J. Klotsche, D. Mengel, Sascha Neumann, R. Dodel   +16 more
semanticscholar   +1 more source

Investigating protein–excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy

mAbs, 2022
Multispecific therapeutic proteins come in a variety of formats, including bi- and tri-specific antibodies, dual-variable domain antibodies, and CrossMabs.
Jainik Panchal, Bradley T. Falk, Valentyn Antochshuk, Mark A. McCoy   +3 more
doaj   +1 more source

Enhancement of T. lymphocyte functions by Fc fragments of immunoglobulin. II. Augmentation of the cell-mediated lympholysis response occurs through an Lyt-1+2- helper T cell.

Journal of Immunology, 1981
Fc fragments derived from papain digestion of human IgG have the capacity to augment specific T cell-mediated cytolytic responses. The addition of Fc fragments to cultures containing nylon wool-purified effector and irradiated stimulator cells results in
E. Morgan, M. Thoman, W. Weigle
semanticscholar   +1 more source

Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats

Frontiers in Molecular Biosciences, 2022
As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies and other new formats, represent a key component in advancing antibody therapy.
Monica L. Fernández-Quintero, Patrick K. Quoika, Florian S. Wedl, Clarissa A. Seidler, Katharina B. Kroell, Johannes R. Loeffler, Nancy D. Pomarici, Valentin J. Hoerschinger, Alexander Bujotzek, Guy Georges, Hubert Kettenberger, Klaus R. Liedl   +11 more
doaj   +1 more source

IVIG regulates the survival of human but not mouse neutrophils

Scientific Reports, 2017
Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled plasma from thousands of healthy donors and are being tested in preclinical mouse models.
Christoph Schneider, Simone Wicki, Stefanie Graeter, Tankica M. Timcheva, Christian W. Keller, Isaak Quast, Danila Leontyev, Iglika K. Djoumerska-Alexieva, Fabian Käsermann, Stephan M. Jakob, Petya A. Dimitrova, Donald R. Branch, Richard D. Cummings, Jan D. Lünemann, Thomas Kaufmann, Hans-Uwe Simon, Stephan von Gunten   +16 more
doaj   +1 more source

An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy

Journal for ImmunoTherapy of Cancer, 2020
Background Recent impressive advances in cancer immunotherapy have been largely derived from cellular immunity. The role of humoral immunity in carcinogenesis has been less understood.
Hui Wang, Jun Li, Min Su, Qian Xu, Weifeng Zhang, Yuping Chen, Xueling Chen, Biying Zhang, Shuming Zhang, Chanyuan Zhao, Jiang Gu, Ziqi Zhu, Xiaoqing Zhu, Junjie Zhou, Tiqun Yang, Meiling Yan, Renming Liu, Changchun Ma, Yan Quan, Yongqu Zhang, Yiqun Geng, Chuangzhen Chen, Shaobin Chen, Ditian Liu, Dongping Tian   +24 more
doaj   +1 more source