Results 41 to 50 of about 90,091 (319)

Mean Field Approach for a Statistical Mechanical Model of Proteins [PDF]

J. Chem. Phys., vol.119, pag.1248 (2003), 2003
We study the thermodynamical properties of a topology-based model proposed by Galzitskaya and Finkelstein for the description of protein folding. We devise and test three different mean-field approaches for the model, that simplify the treatment without spoiling the description.
arxiv   +1 more source

Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica [PDF]

, 2018
Intravenous human immunoglobulin G (IVIG) may have therapeutic benefit in neuromyelitis optica spectrum disorders (herein called NMO), in part because of the anti-inflammatory properties of the IgG Fc region.
Felix, Christian M, Morelli, Adriana Baz, Spirig, Rolf, Tradtrantip, Lukmanee, Verkman, AS   +4 more
core   +1 more source

Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12

Cell Reports, 2013
The human immunoglobulin G (IgG) 2G12 recognizes high-mannose carbohydrates on the HIV type 1 (HIV-1) envelope glycoprotein gp120. Its two antigen-binding fragments (Fabs) are intramolecularly domain exchanged, resulting in a rigid (Fab)2 unit including ...
Yunji Wu, Anthony P. West, Jr., Helen J. Kim, Matthew E. Thornton, Andrew B. Ward, Pamela J. Bjorkman   +5 more
doaj   +1 more source

Breakdown of Scale Invariance in the Phase Ordering of Fractal Clusters [PDF]

PRL 80, 4693 (1998), 1998
Our numerical simulations with the Cahn-Hilliard equation show that coarsening of fractal clusters (FCs) is not a scale-invariant process. On the other hand, a typical coarsening length scale and interfacial area of the FC exhibit power laws in time, while the mass fractal dimension remains invariant. The initial value of the lower cutoff is a relevant
arxiv   +1 more source

Conjunctive Queries for Logic-Based Information Extraction [PDF]

arXiv, 2022
This thesis offers two logic-based approaches to conjunctive queries in the context of information extraction. The first and main approach is the introduction of conjunctive query fragments of the logics FC and FC[REG], denoted as FC-CQ and FC[REG]-CQ respectively.
arxiv  

Bordetella parapertussis Survives inside Human Macrophages in Lipid Raft-Enriched Phagosomes [PDF]

, 2014
Bordetella parapertussis is a human pathogen that causes whooping cough. The increasing incidence of B. parapertussis has been attributed to the lack of cross protection induced by pertussis vaccines. It was previously shown that B. parapertussis is able
Gorgojo, Juan Pablo, Harvill, Eric, Rodriguez, Maria Eugenia   +2 more
core   +3 more sources

A comparative study of the in vitro immunomodulatory activity of human intact immunoglobulin (7S IVIG), F(ab′)2 fragments (5S IVIG) and Fc fragments. Evidence for post‐transcriptional IL‐2 modulation

Immunology, 1997
During the past few decades intravenous immunoglobulin (IVIG) has been used successfully in the treatment of various immunoregulatory disorders. Treatment results have been attributed to immunomodulation mainly via Fc receptors or by anti‐idiotypic ...
D. Nachbaur, M. Herold, B. Eibl, H. Glassl, H. Schwaighofer, C. Huber, A. Gächter, M. Pichl, D. Niederwieser   +8 more
semanticscholar   +1 more source

Production of highly and broad-range specific monoclonal antibodies against hemagglutinin of H5-subtype avian influenza viruses and their differentiation by mass spectrometry

Virology Journal, 2018
Background The highly pathogenic avian influenza viruses of the H5 subtype, such as the H5N1 viral strains or the novel H5N8 and H5N2 reassortants, are of both veterinary and public health concern worldwide. To combat these viruses, monoclonal antibodies
Violetta Sączyńska, Anna Bierczyńska-Krzysik, Violetta Cecuda-Adamczewska, Piotr Baran, Anna Porębska, Katarzyna Florys, Marcin Zieliński, Grażyna Płucienniczak   +7 more
doaj   +1 more source

Investigating protein–excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy

mAbs, 2022
Multispecific therapeutic proteins come in a variety of formats, including bi- and tri-specific antibodies, dual-variable domain antibodies, and CrossMabs.
Jainik Panchal, Bradley T. Falk, Valentyn Antochshuk, Mark A. McCoy   +3 more
doaj   +1 more source

Anti-immunoglobulin antibodies. III. Properties of sequential anti- idiotypic antibodies to heterologous anti-gamma globulins. Detection of reactivity of anti-idiotype antibodies with epitopes of Fc fragments (homobodies) and with epitopes and idiotopes (epibodies)

Journal of Experimental Medicine, 1982
Murine anti-V region antibodies against a human monoclonal protein Gl with anti-gamma-globulin activity and bearing the Wa cross-reactive idiotype were prepared in several strains of mice.
C. Bona, S. Finley, S. Waters, H. Kunkel
semanticscholar   +1 more source