Results 51 to 60 of about 90,091 (319)

Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats

Frontiers in Molecular Biosciences, 2022
As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies and other new formats, represent a key component in advancing antibody therapy.
Monica L. Fernández-Quintero, Patrick K. Quoika, Florian S. Wedl, Clarissa A. Seidler, Katharina B. Kroell, Johannes R. Loeffler, Nancy D. Pomarici, Valentin J. Hoerschinger, Alexander Bujotzek, Guy Georges, Hubert Kettenberger, Klaus R. Liedl   +11 more
doaj   +1 more source

Optimisation and validation of a PCR for Antigen Receptor Rearrangement (PARR) assay to detect clonality in canine lymphoid malignancies [PDF]

, 2016
PCR for antigen receptor gene rearrangements (PARR) analysis is being increasingly used to assist diagnosis of canine lymphoma. In this study, PARR was carried out on consecutive samples received as part of routine diagnostic practice from 271 patients ...
Gallagher, Alice, Haining, Hayley, Jarrett, Ruth F., Johnston, Pamela E.J., Marchesi, Francesco, Morris, Joanna S., Waugh, Elspeth M.   +6 more
core   +1 more source

A Comprehensive Comparative Study of Word and Sentence Similarity Measures [PDF]

International Journal of Computer Applications,2016,135(1), Foundation of Computer Science (FCS), NY, USA, 2016
Sentence similarity is considered the basis of many natural language tasks such as information retrieval, question answering and text summarization. The semantic meaning between compared text fragments is based on the words semantic features and their relationships.
arxiv   +1 more source

The Human Cytomegalovirus Fc Receptor gp68 Binds the Fc CH2-CH3 Interface of Immunoglobulin G [PDF]

, 2008
Recognition of immunoglobulin G (IgG) by surface receptors for the Fc domain of immunoglobulin G (Fc{gamma}), Fc{gamma}Rs, can trigger both humoral and cellular immune responses.
Bjorkman, Pamela J., Cheung, Evelyn J., Deis Trujillo, Robin, Farley, Alexander H., Hengel, Helmut, Reinhard, Henrike, Sprague, Elizabeth R.   +6 more
core   +3 more sources

Enhancement of T. lymphocyte functions by Fc fragments of immunoglobulin. II. Augmentation of the cell-mediated lympholysis response occurs through an Lyt-1+2- helper T cell.

Journal of Immunology, 1981
Fc fragments derived from papain digestion of human IgG have the capacity to augment specific T cell-mediated cytolytic responses. The addition of Fc fragments to cultures containing nylon wool-purified effector and irradiated stimulator cells results in
E. Morgan, M. Thoman, W. Weigle
semanticscholar   +1 more source

Structure of FcRY, an avian immunoglobulin receptor related to mammalian mannose receptors, and its complex with IgY [PDF]

, 2011
Fc receptors transport maternal antibodies across epithelial cell barriers to passively immunize newborns. FcRY, the functional counterpart of mammalian FcRn (a major histocompatibility complex homolog), transfers IgY across the avian yolk sac, and ...
BENNETT, Bottcher, Burmeister, Dube, East, Kowalczyk, Leach, Linden, Llorca, Martin, Mayer, Mertens, P. J. Bjorkman, Rivera-Calzada, Roopenian, Simister, Simister, Taylor, Tressler, Vaughn, Western, Woof, Y. He   +22 more
core   +3 more sources

The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands. [PDF]

, 2015
The human IgG1 antibody subclass shows distinct properties compared with the IgG2, IgG3, and IgG4 subclasses and is the most exploited subclass in therapeutic antibodies. It is the most abundant subclass, has a half-life as long as that of IgG2 and IgG4,
Abe, Andrusier, Ashish, Ashton, Boehm, Brekke, Bruhns, Brüggemann, Calmettes, Collins, Dall'Acqua, Dangl, Davies, Deisenhofer, Diebolder, Dorai, Feinstein, Furtado, Gaboriaud, Gar Kay Hui, Garcia de la Torre, García De La Torre, Glatter, Gregory, Guddat, Guex, Hamilton, Harris, Harris, Heenan, Hezareh, Hughes-Jones, Idusogie, Isenman, Iwura, Jayesh Gor, Jefferis, Kilár, Klein, Laue, Lilyestrom, Lucy E. Rayner, Lund, Luo, Manning, Marquart, Michaelsen, Narayanan, Paul A. Dalby, Perkins, Perkins, Perkins, Perkins, Phillips, Pilz, Radaev, Radaev, Rayner, Rayner, Remmele, Richard K. Heenan, Richardson, Roux, Saphire, Saphire, Sarma, Schneider, Schneidman-Duhovny, Schuck, Schuck, Semenyuk, Sondermann, Stephen J. Perkins, Strohl, Sun, Tamm, Tao, Thommesen, Wang, Yang   +79 more
core   +1 more source

Bacterial Proteins and Their Proposed Interactions with Fc or Fab Fragments of Immunoglobulins

Biochemistry & Physiology: Open Access, 2014
The reactivity of Immunoglobulin Binding Proteins (IBP) to Fc and/or Fab fragments of immunoglobulins was summarized in this review. Staphylococcal protein A (SpA), Streptococcal protein G and Peptostreptococcal protein L (SpL) were the IBP reported. SpA reacted with IgG from skunk, coyote, raccoon, mule and donkey.
Angel A. Justiz Vaillant
openalex   +3 more sources

A novel Pyroptosis‐related long non‐coding RNA signature for predicting the prognosis and immune landscape of head and neck squamous cell carcinoma

Cancer Medicine, Volume 11, Issue 24, Page 5097-5112, December 2022., 2022
our findings robustly demonstrate that our constructed prlncRNA signature could serve as an efficient indicator of prognosis, immunotherapy response, and chemosensitivity for HNSCC patients. Abstract Background Pyroptosis plays an essential function in carcinogenesis and the antitumor immune response.
Chongchang Zhou, Yiming Shen, Yangli Jin, Zhisen Shen, Dong Ye, Yi Shen, Hongxia Deng   +6 more
wiley   +1 more source

An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy

Journal for ImmunoTherapy of Cancer, 2020
Background Recent impressive advances in cancer immunotherapy have been largely derived from cellular immunity. The role of humoral immunity in carcinogenesis has been less understood.
Hui Wang, Jun Li, Min Su, Qian Xu, Weifeng Zhang, Yuping Chen, Xueling Chen, Biying Zhang, Shuming Zhang, Chanyuan Zhao, Jiang Gu, Ziqi Zhu, Xiaoqing Zhu, Junjie Zhou, Tiqun Yang, Meiling Yan, Renming Liu, Changchun Ma, Yan Quan, Yongqu Zhang, Yiqun Geng, Chuangzhen Chen, Shaobin Chen, Ditian Liu, Dongping Tian   +24 more
doaj   +1 more source